Navigation Links
Protein wields phosphate group to inhibit cancer metastasis
Date:1/3/2011

HOUSTON - By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January issue of Nature Cell Biology.

In addition to highlighting a novel anti-cancer pathway, the team found that the same deactivation of the enzyme called EZH2 is necessary for the formation of bone-forming cells from the stem cells that make them and other tissues.

"EZH2 is overexpressed in aggressive solid tumors and tied to cancer progression and metastasis," said the paper's senior author, Mien-Chie Hung, Ph.D., professor and chair of MD Anderson's Department of Molecular and Cellular Oncology. "We have found that another protein, CDK1, deactivates EZH2."

The team's basic research findings provide a rationale for developing an EZH2 inhibitor or a drug that mimics the protein that deactivates it as new cancer drugs. "You have to understand the molecular details of cancer formation and progression to develop new therapies that improve treatment and prevention," Hung said.

In a series of experiments, the team demonstrated how CDK1 interferes with EZH2, reducing cell migration and invasion in breast cancer cell lines.

EZH2 silences gene expression by attaching a methyl group, which consists of one carbon and three hydrogen atoms, to a histone protein that is intertwined with DNA and other proteins to compose chromosomes. Genes suppressed by this methylation include tumor suppressors that would otherwise prevent cancer growth and spread.

The team showed that CDK1 short-circuits EZH2-mediated methylation by attaching a different chemical group consisting of one phosphate and three oxygen atoms to EZH2, a process called phosphorylation. And that phosphorylation has to occur at a specific amino acid on EZH2 to have this effect.

It's a matter of ph
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein wields phosphate group to inhibit cancer metastasis
(Date:12/17/2014)... 17, 2014 Project Veritas is releasing ... videos of MIT economist and Obamacare architect Jonathan Gruber ... O’Keefe conducted the interview, which is being distributed on ... was intentional mislabeling in the Affordable Care Act in ... A two-hundred-and-fifty billion dollar per year tax grab. , ...
(Date:12/17/2014)... parents should leave prenatal picture-taking to medical professionals, the ... ultrasound imaging and heartbeat monitors to get "keepsake" images ... "Although there is a lack of evidence ... monitors, prudent use of these devices by trained health ... engineer, said in an agency news release. "Ultrasound ...
(Date:12/17/2014)... Alan Mozes HealthDay Reporter ... party season fast approaching, a new study reveals that states ... have fewer drunk drivers on their roads. The finding ... are better able to deter inebriated revelers from getting behind ... laws are being passed regarding drinking and driving," said study ...
(Date:12/15/2014)... (PRWEB) December 15, 2014 A recent ... United States women as impacting skin health and beauty ... C’s of skin care.” Water and health advocate and ... a recent article describing the survey and the Four ... item in every category discussed would benefit from paying ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s ... new study providing evidence on the impact of 100% ... , Sufficient enough evidence already exists showing a negative ... drinks, with the onset of tooth decay. One question ... as 100% fruit juice, meaning it is completely natural ...
Breaking Medicine News(10 mins):Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2
... , CHICAGO and PORTLAND, Ore., Jan. ... today that Legacy Health has selected the Allscripts Care ... care facilities, helping to manage and coordinate care for the ... http://www.newscom.com/cgi-bin/prnh/20081013/AQM041LOGO ) , Not-for-profit Legacy provides an integrated network of ...
... , ... Exchange (EPX), a leading merchant acquirer and payment processor, announced today that they have ... Street in Wilmington, Delaware. , ... Wilmington, DE (Vocus) January 11, 2010 -- Electronic Payment Exchange (EPX), a ...
... ... by simply spelling correctly the Hebrew word Sun ( SheMeSh éÞé) in English Letters ... ... 20 years of research, Joseph Lanyadoo concludes that language was neither invented by ...
... headaches what they do when they,re having an attack, and ... And although it,s long been known that light makes migraines ... scientists at Beth Israel Deaconess Medical Center (BIDMC) have identified ... migraine in both blind individuals and in individuals with normal ...
... reach the top, they become more critical of others, less ... News) -- Why do so many people in top positions ... research suggests that power makes people more strict about other ... "According to our research, power and influence can cause a ...
... weight gain, study finds , SATURDAY, Jan. ... work better than traditional health classes in preventing ... excessively fatter, researchers report. , The program ... underlying social and interpersonal difficulties that influence individuals ...
Cached Medicine News:Health News:Legacy Health Selects Allscripts Care Management for Hospitals and Post-Acute Care Facilities 2Health News:Legacy Health Selects Allscripts Care Management for Hospitals and Post-Acute Care Facilities 3Health News:Legacy Health Selects Allscripts Care Management for Hospitals and Post-Acute Care Facilities 4Health News:Legacy Health Selects Allscripts Care Management for Hospitals and Post-Acute Care Facilities 5Health News:Electronic Payment Exchange Corporate Headquarters Moves to a New Location to Support Record Growth 2Health News:New 20 Year Research Confirms the Biblical Assertion that Hebrew is the Original Proto-Language Confounded By the Gods 2Health News:New 20 Year Research Confirms the Biblical Assertion that Hebrew is the Original Proto-Language Confounded By the Gods 3Health News:New 20 Year Research Confirms the Biblical Assertion that Hebrew is the Original Proto-Language Confounded By the Gods 4Health News:Study explains why light worsens migraine headaches 2Health News:Study explains why light worsens migraine headaches 3Health News:Power Really May Lead to Moral Hypocrisy 2
(Date:12/15/2014)... of Ghana has endorsed a project proposed ... BCT to respond to the emerging Ebola crisis within ... capacity to the citizens of Ghana . ... Resilience Initiative (GERRI) is a multi-agency effort designed to: , ... of the Ebola epidemic , Provide new blood product collection ...
(Date:12/13/2014)... Research and Markets ( http://www.researchandmarkets.com/research/2r6bmg/drug_injection ... "Drug Injection Devices to 2020" report to ... As new drugs become available ... health conditions, drug developers have increasingly pursued packaging ... and increase the efficiency and reliability with which ...
(Date:12/13/2014)... 2014 HudsonAlpha Institute for Biotechnology today ... sequencing system manufactured by Illumina, Inc. (NASDQ: ILMN). ... analyze genomic data faster and at a lower ... to research programs for genomics excellence in patient ... unprecedented capacity, speed and accuracy for sequencing individuals, ...
Breaking Medicine Technology:Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 2Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 4Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 5Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 6Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3
... 25, 2011 PDI, Inc. (Nasdaq: ... and commercialization services to health care companies, today announced ... 10 pharmaceutical company has been renewed for an additional ... Shared Sales team beginning in September 2011 through March ...
... 2011 Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN ) ... who has conducted multiple clinical studies of zinc lozenges for the ... Mr. Eby is a pioneer in the development of zinc ... more than 30 years to the study of zinc and is ...
Cached Medicine Technology:PDI Announces Renewal of Engagement for 7th Consecutive Season 2Adeona Appoints George A. Eby to Scientific Advisory Board 2Adeona Appoints George A. Eby to Scientific Advisory Board 3Adeona Appoints George A. Eby to Scientific Advisory Board 4
... Cordis' SAPPHIRE study revealed a low TLR ... Cordis system's excellent integrity and long-term durability., ... withstands pressure of the carotid artery, increasing ... Accurate, Easy Placement: Minimal stent shortening, ...
... device for the qualitative detection of drug or ... device can detect up to nine of the ... minutes and requires only a few drops of ... maximize convenience and ease of use. TOX/See features ...
... is a 1-step, hand-held, point-of-care device for the ... human urine. The TOX/See device can detect ... drugs in 3 to 8 minutes and requires ... cassette is individually packaged to maximize convenience and ...
... point-of-care device for the qualitative detection of drug ... TOX/See device can detect up to nine of ... 8 minutes and requires only a few drops ... to maximize convenience and ease of use. TOX/See ...
Medicine Products: