Navigation Links
Protein tug of war points toward better therapies for cardiovascular disease
Date:11/15/2012

nt to minimize negative side effects while providing protection," Fulton said.

In this case, a better approach appears to be directly increasing the expression of Hsp70 with a drug such as geranylgeranylacetone, or GGA, an antiulcer drug used in Japan with relatively few side effects, Chen said. When the MCG researchers treated human aortic vascular smooth muscle cells with the drug, for example, Hsp70's binding to Nox increased while Nox's ability to generate superoxide decreased.

Next steps include looking at whether this increased expression of Hsp70 actually translates to healthier blood vessels in a cardiovascular model. "If we can upregulate Hsp70 without affecting nitric oxide synthase, it should," said Fulton, the study's corresponding author.

Hsp70 and 90 are chaperones that guide protein folding in different ways and can influence more than just whether Nox enzymes are stable or degraded. Hsp70 levels are regulated by the molecule heat shock factor, which is bound to and repressed by Hsp90. That's one reason why Hsp90 inhibitors increase Hsp70 levels.

Reactive oxygen species are not all bad, the researchers noted. At normal levels, they aid cell signaling and homeostasis as well as the mounting of an immune response. However, excessive levels associated with chronic inflammation are thought to accelerate cardiovascular disease. "A little bit is good; you want a well-honed immune system to fend of pathogens," Fulton said. "Chronic inflammation is the problem."

The researchers completed their studies in normal and diabetic mice diabetes increases the risk of cardiovascular disease by at least 50 percent as well as the saphenous, or major superficial leg veins, of patients with cardiovascular disease.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
2. G proteins regulate remodelling of blood vessels
3. UMass Amherst cell biologists identify new protein key to asymmetric cell division
4. Protein reveals diabetes risk many years in advance
5. A protein’s role in helping cells repair DNA damage
6. Unique protein bond enables learning and memory
7. Pinning protein could answer provocative cancer question
8. Salk study finds diabetes raises levels of proteins linked to Alzheimers features
9. Protein regulation linked to intellectual disability
10. Lactation protein suppresses tumors and metastasis in breast cancer
11. Treating Sperm With Missing Protein Might Help Male Fertility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein tug of war points toward better therapies for cardiovascular disease
(Date:8/27/2014)... 27, 2014 BESLER Consulting , ... services for hospitals, is pleased to announce that it ... of America’s Fastest-Growing Companies. The list represents the most ... independent entrepreneurs. , "It's been an exciting year ... included in this year's Inc. 5000 list,” said Jonathan ...
(Date:8/27/2014)... designed to help regulate the blood,s iron supply shows promise ... to results from the first human study of ... , the Journal of the American Society of Hematology ... blood cells are in short supply or do not function ... get enough oxygen, since there are fewer red blood cells ...
(Date:8/27/2014)... State University,s Center for Leadership in Disability (CLD) ... Maternal and Child Health Bureau of the Health ... the Autism Plan for Georgia, aimed at improving ... disorder. , In preparing for this project, CLD ... key stakeholders from across Georgia. The resulting plan ...
(Date:8/27/2014)... Cash House 's contributions to Horizons ... upkeep of the shelter including new initiatives and a wide ... the lives of each youth who walk through their door. ... for youth ages 16-25. Not only does Horizons operate as ... for the youth who come through their doors. Horizons has ...
(Date:8/27/2014)... Houston, TX (PRWEB) August 27, 2014 ... The reality is that depression has a mortality ... those with bi-polar disorder is slightly less, though it's ... of roughly 7%. In order to properly treat ... schizophrenia, and bi-polar, medication must be taken as directed. ...
Breaking Medicine News(10 mins):Health News:BESLER Consulting Among America’s Fastest Growing Private Companies 2Health News:Drug represents first potential treatment for common anemia 2Health News:Cash House a Major Supporter of Horizons for Youth 2Health News:Cash House a Major Supporter of Horizons for Youth 3Health News:MedicationDiscountCard.com now Makes Brintellix and Mental Illness Medications More Affordable with Discount Cards 2
... Kingdom recently instituted guidelines banning physicians, white coats and ... of bacteria within hospitals due to the belief that ... new study published today in the Journal of ... there is no difference in contamination of long- and ...
... - In an international Phase III randomized study, ... rapamycin (mTOR), has shown to dramatically improve progression-free ... (pNET), according to researchers from The University of ... findings were published in the latest New England ...
... Maureen Salamon HealthDay Reporter , WEDNESDAY, Feb. ... more than doubled the progression-free survival time for patients ... two new studies. In separate phase 3 trials ... sunitinib extended the survival of participants with advanced pancreatic ...
... Feb. 9 (HealthDay News) -- About one in 10 ... after. Though typically harmless, some may need treatment because ... "There are several different types of birthmarks, so it ... considering any possible treatments," dermatologist Dr. Sheila Fallon Friedlander, ...
... the National Institutes of Health envisions scientists being able ... gaining new insights into multi-gene disorders in the next ... drug targets and the development of practical treatments for ... plan from the National Human Genome Research Institute (NHGRI). ...
... PARK, Md. -- Under our feet and ubiquitous, lowly soil ... change and population growth. But in the January-February issue of ... team of scientists say soil is an essential piece of ... it. Strategies for doing so include refocusing and boosting research, ...
Cached Medicine News:Health News:Long- and short-sleeved physician workwear receive same amount of bacterial and MRSA contamination 2Health News:Everolimus improves progression-free survival for patients with rare pancreatic cancer 2Health News:Everolimus improves progression-free survival for patients with rare pancreatic cancer 3Health News:2 Experimental Drugs Show Promise for Rare Pancreatic Cancer 2Health News:2 Experimental Drugs Show Promise for Rare Pancreatic Cancer 3Health News:Not All Birthmarks Harmless, Expert Says 2Health News:NHGRI charts course for the next phase of genomics research 2Health News:NHGRI charts course for the next phase of genomics research 3Health News:NHGRI charts course for the next phase of genomics research 4Health News:Soil science: Healing our planet's ills from the ground up 2
(Date:8/27/2014)... Aug. 27, 2014 Decision Resources Group finds ... Memphis health system and hospital ... integration, with rivals Methodist Le Bonheur Healthcare and Baptist ... to coordinate patient care. In addition, a national contract ... most health plan enrollment in the Memphis ...
(Date:8/27/2014)... By now, if you haven,t heard about the ALS Ice ... awareness campaign has brought this devastating disease to the forefront ... Million (and counting) for ALS. Every day, more and more ... as well. One such company, Acorn Stairlifts Inc., ... works with ALS sufferers and helps to provide solutions for ...
(Date:8/27/2014)... 2014 Reportlinker.com announces that a new ... Global Heart Valve Repair and Replacement ... About Heart Valve Repair and Replacement ... which control the flow of blood during the ... diseases such as valvular stenosis, valvular insufficiency or ...
Breaking Medicine Technology:Memphis-area Health Systems Turn Attention to Clinical Integration 2Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4
9 mm diameter pigtail curved blunt probes. Stainless steel. Round knurled handle with polished finish. Includes pre-cut polyethylene tubes. Overall length: 5.9 inches....
12 mm diameter pigtail curved probes with eyes 4mm back of blunt ends. Stainless steel. Round knurled handle with polished finish. Overall length: 5.9 inches....
The Novus 2000 argon laser combines power, size, and versatility. Ideal for the office, clinic and operating room environments, Novus 2000 is the world's most widely accepted ophthalmic laser....
The VISULAS 532s combines ease of use, efficiency and safety to provide ophthalmologists with an overall system sharply focused on their requirements. ,The VISULAS 532s is a laser of many talent...
Medicine Products: