Navigation Links
Protein tug of war points toward better therapies for cardiovascular disease
Date:11/15/2012

nt to minimize negative side effects while providing protection," Fulton said.

In this case, a better approach appears to be directly increasing the expression of Hsp70 with a drug such as geranylgeranylacetone, or GGA, an antiulcer drug used in Japan with relatively few side effects, Chen said. When the MCG researchers treated human aortic vascular smooth muscle cells with the drug, for example, Hsp70's binding to Nox increased while Nox's ability to generate superoxide decreased.

Next steps include looking at whether this increased expression of Hsp70 actually translates to healthier blood vessels in a cardiovascular model. "If we can upregulate Hsp70 without affecting nitric oxide synthase, it should," said Fulton, the study's corresponding author.

Hsp70 and 90 are chaperones that guide protein folding in different ways and can influence more than just whether Nox enzymes are stable or degraded. Hsp70 levels are regulated by the molecule heat shock factor, which is bound to and repressed by Hsp90. That's one reason why Hsp90 inhibitors increase Hsp70 levels.

Reactive oxygen species are not all bad, the researchers noted. At normal levels, they aid cell signaling and homeostasis as well as the mounting of an immune response. However, excessive levels associated with chronic inflammation are thought to accelerate cardiovascular disease. "A little bit is good; you want a well-honed immune system to fend of pathogens," Fulton said. "Chronic inflammation is the problem."

The researchers completed their studies in normal and diabetic mice diabetes increases the risk of cardiovascular disease by at least 50 percent as well as the saphenous, or major superficial leg veins, of patients with cardiovascular disease.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
2. G proteins regulate remodelling of blood vessels
3. UMass Amherst cell biologists identify new protein key to asymmetric cell division
4. Protein reveals diabetes risk many years in advance
5. A protein’s role in helping cells repair DNA damage
6. Unique protein bond enables learning and memory
7. Pinning protein could answer provocative cancer question
8. Salk study finds diabetes raises levels of proteins linked to Alzheimers features
9. Protein regulation linked to intellectual disability
10. Lactation protein suppresses tumors and metastasis in breast cancer
11. Treating Sperm With Missing Protein Might Help Male Fertility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein tug of war points toward better therapies for cardiovascular disease
(Date:9/1/2014)... MONDAY, Sept. 1, 2014 (HealthDay News) -- You may be ... than unhealthy ones, new research suggests. The study included ... newly designed weight-loss program meant to change how people react ... group of five overweight and obese people who weren,t in ... the start of the study and again six months later. ...
(Date:9/1/2014)... September 01, 2014 Currently, scientists ... effective treatments for Alzheimer's disease (AD), which reflects ... exist regarding the diagnosis of the disease, especially ... of appropriate diagnostic tests. In 2014, after ... greatest breakthroughs in the medicine world, there are ...
(Date:9/1/2014)... 2014 "Women struggle with weight gain ... changes begin as early as 15, if not earlier. ... the ups and downs of hormone related weight gain. ... healthy sizes seems to rage against the hidden and ... in her 40's begin to face menopause and related ...
(Date:9/1/2014)... Monday 1 September 2014: Daily fruit consumption cuts ... 40%, according to research presented at ESC Congress today ... from the seven year follow-up study of nearly 0.5 ... the more fruit people ate, the more their risk ... ischaemic heart disease (IHD) and stroke, is the leading ...
(Date:9/1/2014)... D.C. (PRWEB) September 01, 2014 The ... pleased to announce that Dawn Bazarko, DNP, MPH, RN, ... Fellows of the American Academy of Nursing. They will ... MBA, RN-BC, CCM, FACHE, whose induction we reported last ... October 18, 2014, during the 2014 American Academy of ...
Breaking Medicine News(10 mins):Health News:Train Your Brain to Choose Fruit Salad Over French Fries 2Health News:Early Stage Minimally Invasive Candidate AD Biomarkers Reviewed in New Study by Biopharm Reports Available at MarketPublishers.com 2Health News:Early Stage Minimally Invasive Candidate AD Biomarkers Reviewed in New Study by Biopharm Reports Available at MarketPublishers.com 3Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 2Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 3Health News:Fruit consumption cuts CVD risk by up to 40 percent 2Health News:Fruit consumption cuts CVD risk by up to 40 percent 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4
... Steve Rabenberg, ... to help save his business. Four jobs, many loyal customers and looming bankruptcy are at stake. ... ... the street and wonder, "there used to be a dry cleaners in that strip center, what ...
... on brain injuries and deaths , SATURDAY, May 15 ... start to dust off their bikes, blades and assorted ... to direct public attention toward the importance of wearing ... are riding bicycles, motorcycles and ATVs [all-terrain vehicles] more ...
... False Claims Act Attorney ... Seminar of the Arizona Chapter of the Association of Certified Fraud Examiners on May 17. ... fighting fraud against the Government, and its unique Qui Tam provisions. , ... Phoenix, AZ (PRWEB) May 15, 2010 -- False Claims Act (FCA) ...
... USA The International Association for Dental Research (IADR) ... winners of the annual IADR/GSK Innovation in Oral Care ... oral care technologies that may maintain and improve oral ... its seventh year of award support, GSK Consumer Healthcare ...
... picked up structural variations in critical ,white matter, ... -- Differences in the physical makeup of the ... have trouble with written language despite being able ... , Researchers from Vanderbilt University, Johns Hopkins University ...
... mandated worker education , FRIDAY, May 14 (HealthDay News) ... requires miners to undergo safety education has reduced the ... the regulation a decade ago did not reduce less ... to a study in the July issue of the ...
Cached Medicine News:Health News:Small Business Owner Asks for Donations to Save Jobs and Business - Government Not Helping by Raising Taxes 2Health News:At Any Age, Helmets Make Riding Safer 2Health News:False Claims Act Attorney Tim Terry to Address Arizona Chapter of the Association of Certified Fraud Examiners 2Health News:IADR and GSK Consumer Healthcare announce winners of 2010 Innovation in Oral Care Awards 2Health News:IADR and GSK Consumer Healthcare announce winners of 2010 Innovation in Oral Care Awards 3Health News:Safety Training Makes for Safer Mining 2Health News:Safety Training Makes for Safer Mining 3
(Date:8/29/2014)... -- Research and Markets  has announced the addition of ... report to their offering. The Central Nervous ... largest segments of pharmaceuticals industry. The numbers of CNS disorders ... were unable to meet the market requirements. There has been ... especially over the past two decades. The market for CNS ...
(Date:8/29/2014)... 2014 Does your doctor know what you,re smoking?  ... recommended marijuana to the over 112,000 currently registered patients under ... of the other roughly 20,300+ active physicians listed with the ... it – even though a poll in February 2014 showed ... have tried it. "With marijuana legalization underway, ...
(Date:8/29/2014)... Aug. 29, 2014  United Therapeutics Corporation (NASDAQ: ... Court for the District of New Jersey ... company,s case against Sandoz, Inc. regarding United Therapeutics, Remodulin ... ruled that U.S. Patent No. 6,765,117 is both ... from marketing its generic product until the expiration of ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4District Court Decision Received In Remodulin Patent Case 2
... 2010 CorMatrix Cardiovascular, Inc., an Atlanta-based company ... (ECM) biomaterial devices that harness the body,s innate ... that Franciscan Alliance/St. Francis Heart Center in Indianapolis, ... patient in the multi-center clinical trial of the ...
... Inc. (Nasdaq: ELGX ), developer of minimally ... has completed the acquisition of Nellix, Inc.  Nellix has ... Abdominal Aortic Aneurysms (AAAs) that is expected to address ... and expand the global AAA market. Endologix announced its ...
Cached Medicine Technology:First Patient Enrolled in Multi-Center Clinical Trial of the CorMatrix® ECM® for Pericardial Closure to Reduce the Incidence of New Onset Postoperative Atrial Fibrillation 2First Patient Enrolled in Multi-Center Clinical Trial of the CorMatrix® ECM® for Pericardial Closure to Reduce the Incidence of New Onset Postoperative Atrial Fibrillation 3Endologix Completes Acquisition of Nellix 2Endologix Completes Acquisition of Nellix 3Endologix Completes Acquisition of Nellix 4
... Both the Marco Keratometer ... one position instruments for objectively ... II has the added feature ... presbyopic practitioner or those who ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
Medicine Products: