Navigation Links
Protein tug of war points toward better therapies for cardiovascular disease
Date:11/15/2012

AUGUSTA, Ga. Two proteins are in a tug of war that determines how much the body makes of superoxide, a highly reactive and potentially destructive product of oxygen that's dramatically elevated in cardiovascular disease, researchers report.

Their finding indicates an antiulcer drug just may help the body reduce excessive levels.

Hsp90 and Hsp70 are both heat shock proteins but appear to have opposite effects on reactive oxygen species production, said Dr. David J.R. Fulton, Interim Director of the Vascular Biology Center at the Medical College of Georgia at Georgia Health Sciences University.

"Our studies show that Hsp90 promotes the activity of Nox enzymes, the source of reactive superoxide and all of the reactive oxygen species that descend from it, while Hsp70 has an opposing action that inhibits Nox," Fulton said.

When researchers gave Hsp90 inhibitors, the binding of Nox enzymes to Hsp90 was reduced, its binding to Hsp70 increased and reactive oxygen species production decreased. The inhibitors also reduced reactive oxygen species production in blood vessels from obese mice, where it contributes to the loss of elasticity and narrowing that are hallmarks of cardiovascular disease. While Hsp90 inhibition was known to suppress inflammation and reduce cardiovascular damage, just how it made these positive changes was unknown.

The yin and yang the researchers found points toward a targeted therapy that should give Hsp70 the edge, said Dr. Feng Chen, postdoctoral fellow. Chen is first author of the study in the American Heart Association journal Arteriosclerosis, Thrombosis and Vascular Biology.

Hsp90 inhibitors are used to treat cancer, which depends on Hsp90 to support rapid cell division. But they also target proteins that help blood vessels relax, such as nitric oxide synthase, so probably are not a good choice in cardiovascular disease. "Cardiovascular disease is a chronic disease, and we wa
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
2. G proteins regulate remodelling of blood vessels
3. UMass Amherst cell biologists identify new protein key to asymmetric cell division
4. Protein reveals diabetes risk many years in advance
5. A protein’s role in helping cells repair DNA damage
6. Unique protein bond enables learning and memory
7. Pinning protein could answer provocative cancer question
8. Salk study finds diabetes raises levels of proteins linked to Alzheimers features
9. Protein regulation linked to intellectual disability
10. Lactation protein suppresses tumors and metastasis in breast cancer
11. Treating Sperm With Missing Protein Might Help Male Fertility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein tug of war points toward better therapies for cardiovascular disease
(Date:1/22/2015)... Liberty University has received accreditation for its ... the Council for Accreditation of Counseling & Related Educational ... Center for Counseling & Family Studies , is under the ... new School of Behavioral Sciences. Prior to the formation of ...
(Date:1/22/2015)... 22, 2015 The City of West Hollywood hosted ... to commemorate the 42nd anniversary of the Supreme Court decision Roe ... been 42 years since the Roe vs. Wade decision and the ... present as ever,” said City of West Hollywood Councilmember Abbe Land. ...
(Date:1/22/2015)... TN (PRWEB) January 22, 2015 Gabe’s Chemo Duck ... Duck App, the first app ever created for kids with cancer. ... Apple phones and devices, is filled with enjoyable games to help ... and treatments. The free app helps to keep kids entertained, educated ...
(Date:1/22/2015)... a seasoned and trusted leader who consistently delivers trendy dresses ... it lead the wedding dress industry into the future. Today, ... the global market. , “The CEO of VogueQueen is uniquely ... continuing the goal of operational excellence and giving back to ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many ... it on Facebook, Twitter, and Pinterest. The fans will have ... a lottery every week. , Moreover, the company has extended ... Angelweddingdress homepage for more information. , Angelweddingdress ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2
... (HealthDay News) -- During the holidays, alcohol-related car accidents claim ... according to U.S. government experts. The U.S. National ... percent of traffic-related deaths during Christmas and New Year,s involve ... of the month of December. Facing these troubling ...
... -- About 9.3 million American adults lost health insurance coverage ... times more than in the 2001 recession, according to a ... under age 18 gained health insurance coverage during the recent ... intended as part of the social safety net, said the ...
... Cancer Society has revised its guideline formation process ... creating guidance about cancer screening. The new methods ... Medicine (IOM) by creating a single generalist group ... and clearly articulating the benefits, limitations, and harms ...
... , TUESDAY, Dec. 13 (HealthDay News) -- People with a ... being diagnosed with cancer as the general population, although the ... Myotonic muscular dystrophy (MMD) is characterized by progressive weakness and ... the face, neck, hands and feet. The condition can range ...
... such as bipolar, panic disorder and major depressive disorder ... to a new study led by researchers from the ... that mood and anxiety disorders are highly associated with ... a recent issue of the Journal of Psychological Medicine. ...
... HealthDay Reporter , TUESDAY, Dec. 13 (HealthDay News) -- ... at higher risk for Sudden Infant Death Syndrome (SIDS), ... nervous systems can,t control drops in blood pressure as ... death of an apparently healthy baby. The national Back-to-Sleep ...
Cached Medicine News:Health News:Drunk Driving-Related Deaths Surge During the Holidays 2Health News:Loss of Health Insurance Much Likelier for Adults This Recession 2Health News:American Cancer Society revises cancer screening guideline process 2Health News:Type of Muscular Dystrophy Linked to Raised Cancer Risk 2Health News:Opioid abuse linked to mood and anxiety disorders 2Health News:Opioid abuse linked to mood and anxiety disorders 3Health News:Study Sheds Light on Preemies' Higher SIDS Risk 2
(Date:1/22/2015)... RMD ) today announced results for its quarter ended ... a 10 percent increase compared to the quarter ended December ... basis). Net income was $91.2 million, an increase of 5 ... earnings per share for the quarter were $0.64, an increase ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015  Amgen (NASDAQ: AMGN ... full year 2014 financial results on Tuesday, Jan. 27, 2015, after ... followed by a conference call with the investment community at 2 ... Robert A. Bradway , chairman and chief executive officer, and other ...
(Date:1/22/2015)... Jan. 22, 2015  Profil Institute for Clinical Research, Inc., ... obesity, announced today a new textbook,  Translational Research Methods ... Springer, a leading global scientific publisher. The ... techniques for use in early phase clinical studies of ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... , Oct. 5 Health Strategies Group, ... and biotechnology professionals, has launched a new suite ... essential insights into the complex institutional market, which ... facilities. Offering one-stop convenience, the services give marketers ...
... (Nasdaq: UCTT ), a leading developer and supplier ... solar, and medical device industries, today announced the resignation of ... will immediately begin a search to identify a qualified candidate ... for his service to Ultra Clean and we wish him ...
Cached Medicine Technology:Health Strategies Group Introduces New One-Stop Suite of Intelligence Services for Optimizing Marketing and Sales Resources in the Institutional Channel 2Health Strategies Group Introduces New One-Stop Suite of Intelligence Services for Optimizing Marketing and Sales Resources in the Institutional Channel 3
Maumenee tying forceps is straight with concave-convex jaws and has a round handle with guide pin. For 8-0 to 11-0 sutures....
Jaffe tying forceps is very delicate with smooth jaws, straight, 6 mm long platform. For 8-0 to 11-0 sutures....
Sinskey tying forcep is very delicate with smooth jaws, curved. For 8-0 to 11-0 sutures....
McPherson titanium tying forceps which is 5 mm long, smooth jaws and straight. Used for 8-0 to 11-0 sutures....
Medicine Products: