Navigation Links
Protein tied to cancer drug resistance in mice

SAN ANTONIO, TX (December 7, 2012)Blocking a specific protein renders tumors more vulnerable to treatment in mice, suggesting new therapies could eventually achieve the same in humans, according to new research from Fox Chase Cancer Center to be presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium on Friday, December 7, 2012.

"Hopefully, with further testing, this research could one day result in a new therapy that blocks the effect of this protein and, in turn, boosts the effects of cancer drugs," says study author Elizabeth Hopper-Borge, PhD, Assistant Professor at Fox Chase.

The protein in question is a type of ATP-binding cassette drug efflux pumps, known more simply as ABC proteins. These proteins sit on the membranes of cells, where they act just like pumpsremoving cancer drugs from the cell, thereby making them less effective. The body contains close to 50 such proteins, explains Hopper-Borge, but only 3 appear capable of evading the effects of cancer drugs, including common types used to treat lung, ovarian, and breast cancers.

The current research, supported by the National Institutes of Health, focuses on the protein ABCC10, which has not been studied in as much detail as some other ABC proteins, says Hopper-Borge. Last year, she and her colleagues found that mice lacking ABCC10 experienced physiological changes after taking a cancer drug, suggesting the drug was having an effect.

As part of the latest project, the authors performed a similar experiment in mice engineered to develop breast cancer. They found that, 21 days after exposure to a cancer drug, the tumors that lacked ABCC10 were much smaller than the tumors that still carried the protein. "This is probably the first time it's been shown that removing this protein helps sensitize tumors to cancer drugs," says Hopper-Borge.

Looking closely at the tumors, the researchers also found that cells that lacked ABCC10 grew faster. Strangely, this finding is encouraging, says Hopper-Borge, since chemotherapy targets proliferating cellsand so may explain why the drugs now act on the faster-growing cells that lack ABCC10.

The next step, she says, is to try removing ABCC10 in more mouse models of breast cancer, and determine how active the protein is in different types of the disease. Eventually, if blocking the protein appears to consistently boost the effects of cancer drugs, researchers can identify and begin testing inhibitors of ABCC10 as additional treatments for cancer.

"Although this research is promising, it's in its early stages," cautions Hopper-Borge. "Consequently, it's premature for patients to ask their doctors to test them for the presence of ABCC10, since knowing that can't yet affect their treatment. But these results suggest that may one day change."


Contact: Diana Quattrone
Fox Chase Cancer Center

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
Breaking Medicine Technology: