Navigation Links
Protein thought to protect against oxidative stress also promotes clogging of arteries
Date:1/10/2011

UCLA researchers have found that a protein that plays an important role in some antioxidant therapies may not be as effective due to additional mechanisms that cause it to promote atherosclerosis, or clogging of the arteries.

Published in the January issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology, the finding may give clues as to why some antioxidant therapies have not yielded more positive results.

The protein, called Nrf2, has been thought to be an important drug-therapy target for diseases such as cancer because it can induce chemopreventive activity by attaching to specific sequences of DNA, leading to the release of numerous antioxidant and anti-inflammatory genes and enzymes that can decrease or inhibit the effects of carcinogens.

Researchers reasoned that Nrf2, with its potent ability to boost antioxidants, might also be useful in combating the cell and tissue damage, or oxidation, that leads to atherosclerosis.

However, UCLA scientists found that while Nrf2 boosted antioxidant properties in an animal model, it also increased the development of atherosclerosis by raising plasma cholesterol levels and cholesterol content in the liver.

According to researchers, this is the first study to document these additional effects on cholesterol metabolism in tandem with plaque formation in the arteries.

"We were very surprised at the finding," said principal investigator Dr. Jesus Araujo, director of environmental cardiology at the David Geffen School of Medicine at UCLA. "In fact, the atherosclerosis-producing factors were greater than the antioxidant benefits. The development of novel antioxidant therapies is quite important, and this research may help shed light on why treatments affecting this protein may not be as effective as we thought."

For the study, the team was able to isolate and identify Nrf2's actions by looking at what would happen in mice that w
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... to make it tougher for people to misuse prescription ... approved a new hydrocodone tablet that,s designed to help ... brand name Vicodin -- is a powerful opioid painkiller ... addictions across the United States. The FDA said ... extended-release tablet to treat pain severe enough to require ...
(Date:11/21/2014)... Scientists say they,ve mapped the genome -- the genetic "blueprint" ... in hopes it might help others with this very rare ... Genome Biology , the tapeworm was removed from the brain ... infection is so rare worldwide and completely unexpected in this ... worm was pulled out from the brain," study lead author ...
(Date:11/21/2014)... PLYMOUTH and WOBURN, Mass. (PRWEB) November 21, 2014 ... will present two free workshops titled “Massachusetts Insurance Funding ... autism spectrum disorder (ASD) navigate their way through the ... must be covered under Massachusetts law and the most ... take place on Thursday, Dec. 4 from 6-8:00 p.m. ...
(Date:11/21/2014)... Orange County, CA (PRWEB) November 21, 2014 ... be featured in an upcoming episode of Innovations with ... 2015. Dates and show times TBA. , Big Bud ... with information for growing, harvesting, and utilization of medical ... look at Big Bud Farms’ wide variety of products ...
(Date:11/21/2014)... 21, 2014 Launched today on the ... an all-in-one senior care coordination tool designed to make ... simple and intuitive for family members and caregivers (e.g. ... Now, the family caregiver or home health aide providing ... health data, medical records, goals, schedules, and even final ...
Breaking Medicine News(10 mins):Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 2Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 3Health News:Ick! Tapeworm Infecting Man's Brain Yields Genetic Secrets 2Health News:Center for Autism and Related Disorders to Host Massachusetts Autism Insurance Workshops for Parents 2Health News:Big Bud Farms to be Featured in Upcoming Episode of Innovations with Ed Begley Jr. 2Health News:Comprehensive Senior Care Application Launched on Apple App Store 2
... 2010) -- An experimental immunotherapy may someday become ... Weill Cornell Medical College and Columbia University Medical ... cancer (NSCLC) at NewYork-Presbyterian Hospital as part of ... immunotherapy is intended to prevent cancer recurrence in ...
... Could making child pornography legal lead to lower rates ... to a new study by Milton Diamond, from the ... Czech Republic showed, as seen everywhere else studied (Canada, ... that rape and other sex crimes have not increased ...
... for Responsible Nutrition (CRN), the dietary supplement industry,s leading ... Institute of Medicine,s (IOM) newly-released report on the Dietary ... modest step in the right direction that fell short ... has consistently supported the need for people to significantly ...
... Steven Reinberg HealthDay Reporter , MONDAY, Nov. 29 (HealthDay ... vegetables may be able to help ward off atherosclerosis in adulthood, ... a second new study found that children as young as 9 ... blood pressure that put them at risk of heart disease as ...
... , MONDAY, Nov. 29 (HealthDay News) -- New research suggests ... the progression of cognitive illness among seniors already suffering from ... fact, even healthy people who do not as yet show ... illness by engaging in a similar level of physical activity, ...
... focus of much research since the Institute of Medicine set ... Reference Intakes, the values for these and other nutrients serve ... basis for the development of food guidelines in both the ... are presented in a new IOM report, Dietary Reference Intakes ...
Cached Medicine News:Health News:Experimental vaccine sets sights on lung cancer 2Health News:Legalizing child pornography is linked to lower rates of child sex abuse 2Health News:CRN reacts to Institute of Medicine DRI recommendations for vitamin D 2Health News:CRN reacts to Institute of Medicine DRI recommendations for vitamin D 3Health News:Kids Who Eat Fruits, Veggies May Cut Heart Risk 2Health News:Kids Who Eat Fruits, Veggies May Cut Heart Risk 3Health News:Regular Walking May Slow Decline of Alzheimer's 2Health News:Regular Walking May Slow Decline of Alzheimer's 3
(Date:11/21/2014)...  The University of Maryland,s A. James Clark School ... the new A. James Clark Hall at the University ... transformative new engineering and biomedical technologies to accelerate advancements ... a.m. on November 21 at the site of the ... to the Jeong H. Kim Engineering Building, the event ...
(Date:11/21/2014)... 2014 In September 2014, the staff at ... a new product development plan that started with the ... lab coat , aptly named "Vera G.," after ... the world. The new women,s designer lab coat is ... sleek envelope collar, vertical princess and high waist seaming, ...
(Date:11/21/2014)... 2014  Heated dialogue in recent months about the ... treatments to Gilead,s new hepatitis C drug Harvoni® – ... questioning what it means to put a price on ... And while drug pricing is one of the most ... a general business and ethical standpoint – it is ...
Breaking Medicine Technology:University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 3"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 5
... PowerSuite™ holmium laser combines excellent cutting, ... virtually bloodless procedures. It is also ... gall bladder stones of all compositions, ... tool. Because its laser light is ...
... VersaPulse® PowerSuite™ holmium laser combines excellent ... precise, virtually bloodless procedures. It is ... and gall bladder stones of all ... surgical tool. Because its laser light ...
... leg position for the seated patient and helps ... foot/ankle at 90 degrees to the leg. The ... stand. Stockinette is pulled over the foot and ... a routine fashion. The cast stand is slipped ...
... provides the highest level of protection ... lead protective eyewear. Consistent lens ... allowed. Mfg supervised by Licensed and ... meet or exceed standards for optical ...
Medicine Products: