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Protein that boosts longevity may protect against diabetes
Date:8/8/2012

says.

In the Cell Metabolism study, the researchers analyzed the hundreds of genes that were turned on in mice lacking SIRT1 but fed a normal diet, and found that they were almost identical to those turned on in normal mice fed a high-fat diet.

This suggests that in normal mice, development of metabolic disorders is a two-step process. "The first step is inactivation of SIRT1 by the high-fat diet, and the second step is all the bad things that follow that," Guarente says.

The researchers investigated how this occurs and found that in normal mice given a high-fat diet, the SIRT1 protein is cleaved by an enzyme called caspase-1, which is induced by inflammation. It's already known that high-fat diets can provoke inflammation, though it's unclear exactly how that happens, Guarente says. "What our study says is that once you induce the inflammatory response, the consequence in the fat cells is that SIRT1 will be cleaved," he says.

The researchers also found that as normal mice aged, they were more susceptible to the effects of a high-fat diet than younger mice, suggesting that they lose the protective effects of SIRT1 as they age. Aging is known to increase inflammation, so Guarente is now studying whether that age-related inflammation also provokes SIRT1 loss.


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Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

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