Navigation Links
Protein that boosts longevity may protect against diabetes
Date:8/8/2012

CAMBRIDGE, MA. -- A protein that slows aging in mice and other animals also protects against the ravages of a high-fat diet, including diabetes, according to a new MIT study.

MIT biology professor Leonard Guarente discovered SIRT1's longevity-boosting properties more than a decade ago and has since explored its role in many different body tissues. In his latest study, appearing in the Aug. 8 print edition of the journal Cell Metabolism, he looked at what happens when the SIRT1 protein is missing from adipose cells, which make up body fat.

When put on a high-fat diet, mice lacking the protein started to develop metabolic disorders, such as diabetes, much sooner than normal mice given a high-fat diet.

"We see them as being poised for metabolic dysfunction," says Guarente, the Novartis Professor of Biology at MIT. "You've removed one of the safeguards against metabolic decline, so if you now give them the trigger of a high-fat diet, they're much more sensitive than the normal mouse."

The finding raises the possibility that drugs that enhance SIRT1 activity may help protect against obesity-linked diseases.

Guarente first discovered the effects of SIRT1 and other sirtuin proteins while studying yeast in the 1990s. Since then, these proteins have been shown to coordinate a variety of hormonal networks, regulatory proteins and other genes, helping to keep cells alive and healthy.

In recent years, Guarente and his colleagues have deleted the gene from organs such as brain and liver to pinpoint its effects more precisely. Their previous work has revealed that in the brain, SIRT1 protects against the neurodegeneration seen in Alzheimer's, Huntington's and Parkinson's diseases.

SIRT1 is a protein that removes acetyl groups from other proteins, modifying their activity. The possible targets of this deacetylation are numerous, which is likely what gives SIRT1 its broad range of protective powers, Guarente
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... July 14, 2014 Doctor Mike Hamilton ... launch of their new company website. The Inception website ... information on chiropractic marketing. It's also a place for ... has to offer. , When contacted at his office, ... version of our main website. Our site is obviously ...
(Date:7/14/2014)... Spine Team Texas continues to stay ... treatment and recovery. Currently all physical therapists at Spine ... for certification in The McKenzie Method. Two therapists, Craig ... program. , “We require certification of our therapists because ... outcomes for spine pain patients,” said Mark Hood, CEO ...
(Date:7/14/2014)... Crystal Dental has recently announced that it ... been made via LAD Solutions in in order to increase ... made in order to draw in new patients that can ... Crystal Dental offers a variety of services for both routine ... Dental include cosmetic dentistry procedures such as porcelain veneers and ...
(Date:7/13/2014)... July 14, 2014 Recently, MagicQuinceaneraDresses.com, a ... its new designs of fashionable Dama dresses . ... these quality products are now on sale. They are ... , The sales manager is happy to unveil the ... we want to bring more benefits for our fans. ...
(Date:7/13/2014)... 2014 Recently, Fadhits.com, the distinguished wedding ... pageant dress promotion. According to the company’s senior ... international market. All the company’s current and prospective customers ... before the end of July. , Fadhits.com is ... of happy customers. The company has its own designers ...
Breaking Medicine News(10 mins):Health News:Doctor Mike Hamilton From Inception Chiropractic Websites Announces the Launch of Their New Website 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 3Health News:Crystal Dental Announces the Opening of New Office Location in Sacramento 2Health News:Fashionable Dama Dresses Unveiled By Well-known Supplier MagicQuinceaneraDresses.com 2Health News:Fashionable Pageant Dresses Now On Sale At Fadhits.com 2
... most, you eat worst at healthy restaurants., The "health ... themselves to higher-calorie side dishes, drinks or desserts than ... health claims, according to a series of new Cornell ... of the Journal of Consumer Research , found ...
... Los Angeles, October 8, 2007 High-risk teenagers who ... drug use by approximately 15 percent versus traditional curricula, ... of Southern California (USC). The study will appear in ... online. , Most substance abuse prevention programs disseminate information ...
... Spats with spouse, kids, others boosts cardiovascular dangers, study ... with those you,re closest to can literally bring on ... study that linked constant bickering to a heightened risk ... other heart risk factors, such as depression or smoking, ...
... Salugen, Inc., a personalized health,and wellness company ... Dopaminergic Genes (DRD1, DRD2, DAT1, & DBH) In,Reward ... Appropriate,Phenotypes For Reward Dependence Behaviors at the XVth ... 2007 in New York City, NY. Dr. ...
... a study published,in the Journal of Women,s Health, ... and Thomson Healthcare (NYSE: TOC ; TSK: ... symptoms that occurred prior to the,detection of ovarian ... patients experienced before an,ovarian cancer diagnosis included abdominal ...
... serotonin reuptake inhibitors (SSRIs), a group of drugs commonly ... gastrointestinal bleeding, according to researchers from Wake Forest University ... taken with aspirin and other similar pain medications, the ... who prescribe these medications should be aware of the ...
Cached Medicine News:Health News:'Healthy' restaurants help make us fat, says a new Cornell study 2Health News:Friends help friends avoid drug use 2Health News:Family Infighting Hurts the Heart 2Health News:Family Infighting Hurts the Heart 3Health News:Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics 2Health News:Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study 2Health News:Common Early-Warning Symptoms of Ovarian Cancer Identified in CDC/Thomson Healthcare Study 3Health News:Anti-depressant drugs can double risk of gastrointestinal bleeding 2Health News:Anti-depressant drugs can double risk of gastrointestinal bleeding 3
(Date:7/10/2014)... 10, 2014  BC Technical, the largest nationwide, non-OEM ... , Inc., a leading provider of Siemens Nuclear Medicine ... agreement naming BC Technical as the authorized provider of ... MiE and BC Technical announced today that the two ... Technical as the service and systems provider for MiE,s ...
(Date:7/10/2014)... WOONSOCKET, R.I. , July 10, 2014 CVS ... its board of directors has approved a quarterly dividend of ... The dividend is payable on August 1, 2014, to holders ... Caremark CVS Caremark is dedicated to helping ... integrated pharmacy company in the United States ...
(Date:1/15/2014)... 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has ... - Global Industry Analysis, Size, Share, Growth, Trends And ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... on patients in order to treat dental impairments, for ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: