Navigation Links
Protein test is first to predict rate of progression in Lou Gehrig’s disease
Date:11/19/2012

There are no curative or even significantly beneficial therapies in clinics now for ALS treatment, but many are in development, Dr. Boylan says. A test like this could help identify those patients who are at risk for faster progression of weakness. With experimental treatments that primarily slow progression of ALS, detecting a treatment response in patients with faster progression may be easier to detect, says Dr. Boylan. Now, patients with varying rates of progression participate together in clinical studies, which can make analysis of a drug's benefit difficult, he says.

"If there were a way to identify people who are likely to have relatively faster progression, it should be possible to conduct therapeutic trials with smaller numbers of patients in less time than is required presently," Dr. Boylan says.

A longer-range goal is to develop tests of this kind to gauge how well a patient is responding to experimental therapies, he adds.

The test measures neurofilament heavy form in blood and spinal fluid. These are proteins that provide structure to motor neurons, and when these nerves are damaged by the disease, the proteins break down and float free in blood serum and in the spinal fluid. Earlier research in this area was conducted by Gerry Shaw, Ph.D., a neuroscientist at the University of Florida, who is the study's senior investigator and the developer of the neurofilament assay used in the study.

The researchers measured neurofilament heavy form in blood and spinal fluid samples from patients at Mayo Clinic and at Emory University, and correlated levels of the protein with rate of progression. "We demonstrated a solid association between higher levels of this protein and a faster progression of muscle weakness," Dr. Boylan says. There was also evidence suggesting that ALS patients with higher protein levels may have shorter survival, he adds.


'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Over 440,000 patients die annually as a result of ... jet airplanes crashing each day. Now more than ever before, ... to do all they can to stay safe. , Through ... U.S. Surgeon General, discusses the importance of safer hospitals. “It’s ... safety issues to ensure that all our patients are in ...
(Date:2/27/2015)... 27, 2015 Muscular Dystrophy Association ... Engineering at Duke University, recently announced a potentially ... young men with Duchenne muscular dystrophy (DMD). The ... and Gersbach will discuss their implications at MDA's ... in Washington, D.C. , Background: Gersbach and ...
(Date:2/27/2015)... Over 440,000 patients die each year as a ... educate readers on how they can take control of their ... a guide to educate and inspire readers to learn more ... safe with tips on topics ranging from hospital to anesthesia ... the print publication. He recently spoke to Mediaplanet ...
(Date:2/27/2015)... 27, 2015 With cases of head ... concerned parents look to school administrations to help prevent the ... head lice is a common parasite that passes easily among ... causing parents and teachers significant distress. , The answer ... at the school. This would allow parents and teachers to ...
(Date:2/27/2015)... Schenectady, New York (PRWEB) February 27, 2015 ... has been named one of the Best Companies to ... , “Transfinder recognizes the importance of creating a great ... a demanding – yet professionally fulfilling – environment. There’s ... doing great work together,” said Antonio Civitella, president and ...
Breaking Medicine News(10 mins):Health News:Dr. Richard Carmona, the 17th U.S. Surgeon General, and IntelliCentrics Raise Awareness in Mediaplanet’s “Patient Safety” Campaign 2Health News:Statement: New MDA-Funded Genetic Therapy Technique Targets DMD 2Health News:Safe and Sound: Improving Patient Outcomes through Mediaplanet’s “Patient Safety” Campaign 2Health News:South Florida Parents Put Pressure on Schools to Perform Lice Screenings to Prevent Spread of Lice According to One Miami Lice Removal Company Called Lice Troopers 2Health News:Transfinder Named a Best Company to Work for in New York State 2
... simple guidelines can help , TUESDAY, May 25 (HealthDay News) ... decade ago, she scoured the Internet looking for treatments. , ... said Anderson, now community scientific liaison at Kennedy Krieger Institute,s ... nonsense. It was hope. People will try all sorts of ...
... ... to get their important messages across to employees, snap out of it! SnapComms ... , ... May 20, 2010 -- Toronto-based Hoppen Group Incorporated, one of Canada,s top internal communications ...
... ... grill tips and secrets with Sam,s Club - ensuring that you turn out perfectly grilled ... Bentonville, ... a great Memorial Day cookout? Pitmaster, barbecue champion and cookbook author Troy Black shares his ...
... , ... , a leading provider of interoperable workflow solutions, announced today the availability of a ... transitions and close information gaps between systems, departments and facilities through collaboration and clinical ... ...
... ... of its new online health book category with The Myth About Stress by Michael ... , ... AZ (PRWEB) -- Nutri-Health Supplements, LLC, a leader in direct-to-consumer probiotic supplements, announces the ...
... Orders for OPA Digest May ... (PRWEB) -- A ... Mr. William Bode, Esq., managing partner of the law firm of Bode & Grenier, LLP ... starting today. The Digest was originally published in 2004 and contains a summary, organized by ...
Cached Medicine News:Health News:As Autism Web Sites Boom, Experts Urge Caution 2Health News:As Autism Web Sites Boom, Experts Urge Caution 3Health News:The Hoppen Group Announces Partnership with SnapComms Tools 2Health News:The Hoppen Group Announces Partnership with SnapComms Tools 3Health News:Memorial Day Grilling: "How-to" Secrets and Tips from Barbecue Champ Troy Black and Sam's Club For The Perfect Memorial Day Cookout 2Health News:Expert Insights on Health Data Sharing, Collaboration, Quality and Meaningful Use Featured in Latest Carefx Position Paper 2Health News:Expert Insights on Health Data Sharing, Collaboration, Quality and Meaningful Use Featured in Latest Carefx Position Paper 3Health News:New Book Says Good Stress and Probiotics can Change Your Life 2
(Date:2/27/2015)... , Feb. 27, 2015  Pomerantz LLP is ... Inc. ("Vitae" or the "Company") (NASDAQ: VTAE ... S. Willoughby at rswilloughby@pomlaw.com or 888-476-6529, ... and certain of its officers and/or directors have violated ... of 1934.  On February 27, 2015, ...
(Date:2/27/2015)...  Pharmacyclics, Inc. (NASDAQ: PCYC ) ... in the Proceedings of the National Academy ... when ibrutinib (IMBRUVICA ® ) was combined with ... tumor growth was enhanced suggesting a greater response ... and solid tumors with the combination. IMBRUVICA is ...
(Date:2/27/2015)...  Acsis Inc., the market leader for supply chain ... John DiPalo , Acsis, Chief Strategy Officer, has ... Executive 2015 Provider Pro to Know. The award ... help prepare their companies, and customers, supply chains for ... list of Provider Pros to Know is featured in ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Vitae Pharmaceuticals, Inc. - VTAE 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 3In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 4In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 5In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 6In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 7In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 8In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 9Acsis CSO John DiPalo Named Supply & Demand Chain Executive 2015 Pro to Know 2
... AcelRx Pharmaceuticals, Inc. announced today that results ... of its oral transmucosal NanoTab(TM) formulation of sufentanil ... the upcoming American Society of Anesthesiologists Annual Meeting ... Officer of AcelRx, will present in the following ...
... Oct. 15 Azopharma Product Development Group, LLC, ... services and PharmaNet Development Group, Inc., a leading ... biotechnology, generic drug and medical device companies, are ... development and co-promotion alliance to leverage complementary services, ...
Cached Medicine Technology:Azopharma and PharmaNet Development Group Enter Preclinical Strategic Alliance 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: