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Protein targeted to stop melanoma tumor growth
Date:12/9/2010

cer.

"This suggests that the MIC-1 protein produced and secreted by these tumors might be performing an important role in the development of melanoma by controlling a key process outside of the tumor," Robertson said.

MIC-1 stands for macrophage inhibitory cytokine-1, a member of a group of proteins that regulate cellular proliferation, migration, adhesion and immune surveillance. It was originally discovered to be associated with regulating inflammation.

By targeting MIC-1, protein levels dropped 300 to 400 percent in animal and human tissue samples, preventing blood vessel formation and decreasing tumor development by about 300 percent.

"Therapies removing MIC-1 from the blood of patients could be used to prevent tumor vessel development," says Robertson "and as a result, the tumors would not be able to get bigger because of a lack of needed nutrition and removal of toxic cell waste products. Thus, a drug performing the job of MIC-1 removal would be an important part of a therapeutic arsenal of agents to more effectively treat melanoma."


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Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2

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