Navigation Links
Protein synthesis blocker may hold key to reducing effects of traumatic events
Date:3/4/2013

This release is available in French.

Reducing fear and stress following a traumatic event could be as simple as providing a protein synthesis blocker to the brain, report a team of researchers from McLean Hospital, Harvard Medical School, McGill University, and Massachusetts General Hospital in a paper published in the March 4 issue of Proceedings of the National Academy of Sciences.

"This is an important basic neuroscience finding that has the potential to have clinical implications for the way individuals with posttraumatic stress disorder are treated," said Vadim Bolshakov, PhD, director of the Cellular Neurobiology Laboratory at McLean Hospital. "We used a well known behavioral paradigm that we think models PTSD, fear conditioning, to explore how fearful memories are formed. In our study, the level of fear exhibited by experimental subjects was significantly reduced as a result of decreased signal transfer between cells in the amygdala, a key brain region in fear-related behaviors."

Influenced by the original findings of Karim Nader, PhD, professor of Psychology at McGill University, whose pioneering work showed that old memories should be un-stored in their brain after their recollection in order to last, Bolshakov's team exposed rats to auditory stimulus that the animals learned to associate with a mildly traumatic event. After a single exposure to the training procedures, the rats exhibited fear during subsequent exposures to auditory stimuli. The researchers then provided the animals with rapamycin, a protein synthesis blocker, immediately after memory was retrieved in order to control bonding between the cells in the brain. The animals exhibited significantly less fear in response to the fear-invoking stimulus when retested the next day.

"The animals showed stereotypical signs of fear after the initial exposure
'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Discovery of executioner protein opens door to new options for stroke ALS, spinal cord injury
2. Researchers discover how to shutdown cancers powerful master protein
3. Protein balance key in preventing cancer
4. Resurrection of 3-billion-year-old antibiotic-resistance proteins
5. Researchers at the UH Cancer Center discover protein that may control the spread of cancer
6. Cell scaffolding protein fascin-1 is hijacked by cancer
7. BioTrust Low Carb Protein Review Revealed By BioTrust Nutrition Reviews
8. Data on novel IL-1 inhibitor protein for topical treatment of dry eye disease published
9. Low-protein diet slows Alzheimers in mice
10. Protein central to cancer stem cell formation provides new potential target
11. Novel protein may help detect Lou Gehrigs disease and dementia, Mayo Clinic finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Arrow, OK (PRWEB) August 27, 2014 When ... their guests a comfortable bed to sleep without breaking the ... the market for a new foam mattress set for the ... to sleep on, Bedding Mart has it all during their ... stock up on some of the best mattresses for the ...
(Date:8/27/2014)... Millennium Treatment Group is proud to ... Mental Health Counselors Association (FMHCA). The addiction treatment facility ... sure to provide. , FMHCA is an organization dedicated ... mental health counselors. The organization was founded in 1976 ... and since then, it has served the state’s mental ...
(Date:8/27/2014)... August 27, 2014 Today, Zane Benefits, ... on compliance tips for administering a premium reimbursement plan. ... in full effect, compliance is top of mind for ... to individual health insurance and premium reimbursement, there are ... In the 35 minute webinar, Zane Benefits President, Rick ...
(Date:8/27/2014)... (PRWEB) August 28, 2014 Recently, iFitDress.com, ... has announced its new designs of romantic bridal ... can enjoy a promotional price (up to 66 percent ... Now, the company’s product line has been updated with ... professional and patient. iFitDress.com hopes that all clients can ...
(Date:8/27/2014)... 27, 2014 New Jersey’s own Morgan ... Ridgewood County Club during The Barclays – and thanks ... of the tournament’s four rounds, stepped his way into ... Cross Blue Shield of New Jersey (Horizon BCBNSNJ) Walking ... Wyckoff native playing before family and friends at the ...
Breaking Medicine News(10 mins):Health News:Bedding Mart, Top Mattress Store in Broken Arrow Oklahoma, Announces a Huge Labor Day Sale 2Health News:Millennium Treatment Group Sponsors Florida Mental Health Counselors Association 2Health News:Zane Benefits Announces Upcoming Webinar on Compliance 2Health News:Promotion For Romantic Bridal Gowns Launched By Professional Company iFitDress.com 2Health News:Morgan Hoffmann, PGA TOUR Pro & Wyckoff Native, golfs and walks his way to top 10 finish at The Barclays while raising additional $7,500 for charity 2
... H5N1 strain of bird flu, raising to 35 the number of ... ,John Jabbour, a WHO official in Cairo, told AFP ... did not name, was in "very critical" condition. ,She ... girl had been in contact with poultry, he said. ...
... by researchers at the Royal National Orthopaedic Hospital and Kingston ... has a high success rate and is well tolerated by ... ,Mortons neuroma is a growth of nerve tissue ... your third and fourth toes and usually causes a sharp, ...
... Exhausted, stressed out and thinner than she used to be, ... life this week, and she's not even 18 yet . ... hopefuls struggling through China's university placement exams, a pressure-packed, make-or-break ... or trap her down in the faceless masses. ...
... A 24-year-old woman in Orissa Saturday delivered identical triplets, a ... doctor said . ,Rajalakhi Das gave birth to ... ,The babies were born without any medical complications ... hospital paediatrician Nakul Sahoo told IANS. ,He ...
... Manto Tshabalala-Msimang returned to spotlights when she announced that there ... pregnancies among the women of South Africa. No figures were ... our continued focus on prevention as the mainstay of our ... Minister told parliament during a speech on her departmental budget. ...
... recent breakthrough by scientists has made a cup of tea possible ... kettle, which, according to them, can produce a cup of hot ... ,Users fill the Tefal Quick Cup kettle from the tap in ... red button. ,The device sucks up a pre-set amount ...
Cached Medicine News:Health News:Make-or-break Exams Stress China Youth 2Health News:Make-or-break Exams Stress China Youth 3Health News:HIV and AIDS Pregnancies Considerably Reduced- South African Health Minister 2
(Date:8/27/2014)... LOS ANGELES , Aug. 27, 2014   ... , now offers AcceleDent® Aura to patients who want ... to orthodontic care available at the OrthoSpaceship, all patients ... healthier, better-looking teeth. This system can be used by ... boost their rate of progress by using the AcceleDent® ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces that ... its catalogue: Global Heart Valve Repair ... http://www.reportlinker.com/p02316644/Global-Heart-Valve-Repair-and-Replacement-Market-2014-2018.html About Heart Valve Repair ... human heart which control the flow of blood ... heart valve diseases such as valvular stenosis, valvular ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Global Animal ... About Animal Health Animal health ... diseases or treat animals to enhance their quality ... yield of animal food. The Global Animal Health ...
Breaking Medicine Technology:Los Angeles Orthodontist, Dr. Isaac Hakim, is Now Offering AcceleDent Aura 2Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7
... WPI Holdings d/b/a Woodbury Health Products ("Woodbury"), a portfolio ... that it has completed the acquisition of Wilmington Medical ... Carolina and founded in 1993, WMS is a distributor ... urological catheters and sterile kits.  With a client base ...
... ANN ARBOR, Mich., Oct. 12 Incept BioSystems, Inc. ... technology developed at the University of Michigan, announced today ... of its proprietary, SMART Start ™ Embryo Culture ... to the U.S. Food & Drug Administration ("FDA").  A ...
Cached Medicine Technology:WPI Holdings Acquires Wilmington Medical Supply Inc. 2Incept BioSystems Completes First Human Clinical Trial of the SMART Start™ Embryo Culture System and Submits 510(k) Application to the FDA 2Incept BioSystems Completes First Human Clinical Trial of the SMART Start™ Embryo Culture System and Submits 510(k) Application to the FDA 3
... Captia Borrelia burgdorferi (B. burgdorferi) IgG/IgM Enzyme ... the qualitative presumptive (firststep) detection of total ... serum. This ELISA should only be used ... are consistent with Lyme disease. Equivocal or ...
POLYSORB™ sutures are composed of LACTOMER™ glycolide/lactide copolymer which is a synthetic polyester composed of glycolide and lactide (derived from glycolic and lactic acids)....
SURGIPRO™ BLUE Monofilament Suture in two sizes....
Surgitie&trade Single Use Ligating Loops with Delivery System...
Medicine Products: