Protein suppresses allergic respon...(ing multiple organs of the body can lead...),Health

RGS13 is known to inhibit cellular responses induced by G-protein-coupled receptors, which are the most abundant cell surface receptors in the body. It is also known that these receptors are the targets of approximately 60 percent of therapeutic drugs for various diseases. Since RGS13 is expressed in mast cells, Dr. Druey and his NIAID colleagues decided to explore the role of RGS13 in mouse models of anaphylaxis. Through genetic engineering, they made a group of mice deficient in the RGS13 gene. Normal mice served as the control group.

First, the NIAID team compared localized anaphylactic reactions in the two groups. They injected an allergen, IgE antibody and a blue dye under the skin of the mice, similar to the allergy skin test done by physicians. The results showed that RGS13-deficient mice had a larger and more intense blue reaction than normal mice, indicating that their blood vessels leaked more.

To test for systemic anaphylaxis, they injected the allergen, IgE antibody and a blue dye directly into the veins of the mice. The organs of RGS13-deficient mice showed an anaphylactic response that was twice as large as that of the normal mice. In both cases, the results indicate that RGS13 suppresses the anaphylactic response in mice, whereas RGS13 deficiency and abnormal RGS13 expression and function contribute to increased mast cell activity, which occurs during an allergic response, including anaphylaxis.

According to Dr. Druey, the study is also important because for the first time, researchers have shown that RGS13 inhibits the activity of PI3 kinase, an enzyme involved in many biological processes, including those involved in cancer and diabetes. Therefore, the research has implications for numerous other diseases and medical conditions in addition to allergies.

Nex
'/>"/>