Navigation Links
Protein strongest just before death
Date:12/12/2012

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.

The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer.

"Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion," said Liang Zhang, a lead author and MSU cell and molecular biology graduate student. "This is an unusual way for proteins to act."

As an organism grows, proteins essential for fueling its prosperity typically toe a tight line, performing their jobs at the right place and time. If these proteins go rogue, disasters such as cancer can result.

Retinoblastoma proteins, which could be labeled as rebellious as opposed to rogue, perform acts of valor rather than destruction. And just like fireworks, they save their best work for the finale.

Proteins' lifecycles end with degradation, and like most living things they become weaker and less efficient at their jobs near the end of their lives. For Retinoblastoma proteins, however, their destruction is linked to their ability to efficiently control excessive cell growth.

Using the fruit fly Drosophila, MSU researchers isolated the specific region that controls the protein's ability to degrade. Strikingly, this is the same region the protein uses to hit its stride and exert its full power to suppress genes related to unrestrained cell growth. Other categories of genes, such as those linked to cell death, may not be influenced by this specific region that controls degradation. This sheds light on a single mechanism that controls both living and dying at the genetic level.

Identifying this mechanism in fruit flies could be beneficial to humans. David Arnosti, MSU biochemist and director of MSU's Gene Expression in Disease Development initiative, noted the genetic similarities between humans and Drosophila, describing fruit flies as "resembling little people with wings."

"By revealing the molecular details about the regulation of the fly Retinoblastoma protein, we can start to understand the possible roles of the human counterparts in cancer," he said.


'/>"/>

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert  

Related medicine news :

1. Study paves way to design drugs aimed at multiple protein targets at once
2. Blood levels of immune protein predict risk in Hodgkin disease
3. Protein tied to cancer-drug resistance in mice
4. Protein tied to cancer drug resistance in mice
5. Metabolic protein launches sugar feast that nurtures brain tumors
6. Researchers implicate well-known protein in fibrosis
7. Protein test is first to predict rate of progression in Lou Gehrig’s disease
8. Protein tug of war points toward better therapies for cardiovascular disease
9. Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model
10. G proteins regulate remodelling of blood vessels
11. UMass Amherst cell biologists identify new protein key to asymmetric cell division
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein strongest just before death
(Date:9/25/2017)... ... September 25, 2017 , ... Catalent ... for drugs, biologics and consumer health products, today announced that two of its ... of bioassays at two upcoming conferences. , At the BEBPA 10th Annual Bioassay ...
(Date:9/25/2017)... ... ... NCPDP Foundation , a 501(c)(3) nonprofit charitable organization ... grant to Johns Hopkins Medicine to address patient safety risk by implementing CancelRx ... a prescription already submitted to a pharmacy. Studies indicate that up to 3% ...
(Date:9/25/2017)... ... September 25, 2017 , ... Lean ... efficiency. The principle of First-Defect-Stop for laboratory weighing is designed to ... the chance to have negative consequences on downstream processes. , If a problem ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... technology-enabled services supporting clinical research, today announces that 30 of its domain ... the drug development lifecycle at upcoming industry conferences and webinars. Drawing on ...
(Date:9/25/2017)... ... September 25, 2017 , ... Ron Norman, CEO of Team ... upper-level executives speaking at a business luncheon today, "It is tantamount to forgetting ... asset to be fully realized and activated by the corporations that recognize their ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017  Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced that it will be participating ... Healthcare Conference at the Grand Hyatt hotel in New ... 2017 at 11:40 a.m. Eastern Time. A ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:9/6/2017)... Sept. 6, 2017 NeuroRx, a clinical stage biopharma ... and Behavior (ASIB), has been granted Fast Track status by ... of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine + lurasidone). ... trial of this sequential therapy targeting patients who are admitted ... ...
(Date:9/5/2017)... , Sept. 5, 2017  Just 18 months ... Insight is pleased to announce the appointment of three ... Tammy Wynne , Dominic Jones-Phillips and ... industry. Tammy ... team of market access writers. She has over ten ...
Breaking Medicine Technology: