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Protein reveals diabetes risk many years in advance
Date:11/7/2012

d higher than average levels developed diabetes during the period of the study. Among those with a lower than average level, only nine per cent developed the condition.

"This makes it a strong risk marker that is present several years before diagnosis. We have also identified the mechanism for how SFRP4 impairs the secretion of insulin. The marker therefore reflects not only an increased risk, but also an ongoing disease process", says Anders Rosengren.

The marker works independently of other known risk factors for type 2 diabetes, for example obesity and age.

Motivation for lifestyle changes

"If we can point to an increased risk of diabetes in a middle-aged individual of normal weight using a simple blood test, up to ten years before the disease develops, this could provide strong motivation to them to improve their lifestyle to reduce the risk", says Anders Rosengren, adding:

"In the long term, our findings could also lead to new methods of treating type 2 diabetes by developing ways of blocking the protein SFRP4 in the insulin-producing beta cells and reducing inflammation, thereby protecting the cells."


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Contact: Anders Rosengren
Anders.Rosengren@med.lu.se
46-705-316-704
Lund University
Source:Eurekalert

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