Navigation Links
Protein residues kiss, don't tell
Date:6/12/2012

Jos Onuchic has become an expert at connecting the dots, but finding connections merely implied by the dots well, that's quite a trick.

The Rice University biophysicist and his team have created a tool to do just that for proteins and, in the process, have advanced the art of predicting their form and function.

In this case, the dots are amino acid molecules known as residues that link together in chains to form proteins. Proteins are the workhorses that carry out the biological tasks essential to every living thing, but before they can go to work, they fold. Each protein has its own characteristic, folded shape, and various diseases, including cancer, have been linked to proteins that misfold or otherwise misbehave.

As computers grew more powerful over the past three decades, scientists have created many methods to predict how a particular chain of residues is likely to fold and the purpose the resulting protein serves.

Onuchic and colleagues at the Center for Theoretical Biological Physics have developed a tool, known as direct coupling analysis-fold (DCA-fold), that enhances existing methods. Details of their research appear today in the online version of the Proceedings of the National Academy of Sciences (PNAS). The center is currently based at the University of California at San Diego (UCSD) but is relocating to Rice's BioScience Research Collaborative.

While most protein-folding researchers look at the sequence of amino acids in a protein, either through X-ray crystallography of folded proteins or through computer simulations, Onuchic and his colleagues stepped back to look at the DNA sequences that serve as the blueprints for the proteins. By exploiting the increasingly large database of genomic sequence information, they're able to increase the accuracy of predicting the structures of folded proteins.

They start by finding points in the protein-encoding genome sequences that appear to
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Overexpression of proteins 14-3-3 related to chemotherapy resistance
2. Wayne State University researcher examines proteins role in diabetic retinopathy
3. New molecular structure offers first picture of a protein family vital to human health
4. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
5. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
6. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
7. Protein may represent a switch to turn off B cell lymphoma
8. RANK protein promotes the initiation, progression and metastasis of human breast cancer
9. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
10. Unusual protein helps regulate key cell communication pathway
11. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 28, 2014 Top 10 Best SEO Hosting, ... Linux hosting suppliers and announced iPage, Bluehost and GoDaddy are ... Canada, Australia and Europe to buy useful hosting (including VPS ... reliable suppliers, iPage has been serving hosting small ... it has grown into a leader in the hosting industry ...
(Date:8/27/2014)... Sports , the innovative women’s running apparel brand is proud ... noted for her brave running of the 1967 all-male Boston ... clothes that unites the history of women’s competitive running with ... , “It is such an honor to work with this ... original Skirt – she stood strong, pushing herself to be ...
(Date:8/27/2014)... 27, 2014 The Latinos In Action ... and 7th at the Florida State Fair Grounds from ... Latino art and cultures from around the world. Latinos ... sponsor Go Smart Mobile and Univision Mobile, a service ... expecting an estimate of 4,000 people from different backgrounds, ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Seventy-three members ... Pharmacy (SoP) celebrated the beginning of their careers as ... Saturday, August 23. Students entering a four-year PharmD program ... care ?to welcome them into the profession as colleagues ... ceremony held at the Garrison Theater in Claremont, Calif., ...
(Date:8/27/2014)... By Dennis Thompson ... -- Someone who has been mugged in a dark alley ... location with a fear of being attacked. But neuroscientists ... controls how memories are linked with positive and negative emotions. ... the emotions attached to a memory. In essence, they ...
Breaking Medicine News(10 mins):Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2Health News:Marc Anthony to Perform at "Nieves Productions" Latinos in Action Festival 2Health News:Founding Class of the KGI School of Pharmacy Formally Welcomed into the Profession at a Traditional White Coat Ceremony 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3
... study between drug users and HIV infection was done ... of Public Health. The results of the study showed ... the heroin-trafficking countries of Afghanistan to Eastern Europe. ... is, again, ahead of our responses,” says Chris Beyrer. ...
... is a good sign if the bites of the insects ... ,According to scientists at UT Southwestern Medical Center, tenderness may ... deserves more medical attention. ,Other signs of possible infection ... pus, or worsening, rather than improvement, of the site over ...
... to prevent or treat nausea, leading researchers// to believe that ... nausea induced by chemotherapy. ,At present chemotherapy patients ... effect. But for most people, two to five days after ... ,Researchers now say they are studying whether capsules of ...
... consumers in 38 markets it was seen that one in two ... two in five people regularly check for calorie and sugar content. ... labeling, when they would check nutritional information and labeling and what ... ,It was seen that in spite of all the hype about ...
... Trial in Zambia led by Dianne Gibb reported that ... by more than 40% over a 19 month period. ... children with AIDS, which can be just as fatal ... of wide spread resistance to Co-trimoxazole in Zambia, and ...
... only cause breathing problems, but according to the latest// ... diseases and heart attacks. ,Depending on the body ... inhale between 3,000 and 6,000 gallons of air each ... spew a bewildering array of pollutants into that air. ...
Cached Medicine News:Health News:HIV Infection Higher In Drug Trafficking Countries 2Health News:Air Pollution Linked To Heart Disease And Heart Attacks 2
(Date:8/27/2014)... NEW YORK , Aug. 27, 2014 /PRNewswire/ ... report is available in its catalogue: ... http://www.reportlinker.com/p02316641/Global-Animal-Health-Market-2014-2018.html About Animal Health ... prevent animal diseases or treat animals to enhance ... increase the yield of animal food. The Global ...
(Date:8/27/2014)... Aug. 27, 2014 North American lighting leader ... 100 Award for the new OSRAM ITOS ® PHASER ... light module for microscopy, endoscopy and surgical head lamps that ... higher efficacy and lamp life. "We,re honored to ... the most innovative new technologies of the past year," said ...
(Date:8/27/2014)... 27, 2014  CVS Caremark (NYSE: CVS ... clinical affiliation with MedStar Health, a leading health care ... and the Washington, DC , ... care services for patients. Through this clinical affiliation, MedStar ... support, medication counseling, chronic disease monitoring and wellness programs ...
Breaking Medicine Technology:Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3
... , MONTREAL and DUSSELDORF, Germany, Dec. ... solutions, is pleased to announce that FUJIFILM Europe GmbH is now ... several of their PACS and Mammography solutions using Fujifilm ... computer based radiography, offering the world,s first internet-based PACS (SYNAPSE) and ...
... , REDONDO BEACH, Calif., Dec. 1 Reproductive Partners ... (eSET) Encouragement Program to provide a financial incentive for ... for success to consider reducing the chance of twins ... in advanced reproductive technology today is reducing the number ...
Cached Medicine Technology:FUJIFILM Europe Teams Synapse with Matrox Xenia 2FUJIFILM Europe Teams Synapse with Matrox Xenia 3Reproductive Partners Announces Elective Single Embryo Transfer (eSET) Encouragement Program 2
... Avant Premium Eppendorf Style Low Binding, Graduated ... Designed to fit Eppendorf Style Pipettors.Reduces DNA ... Produced & packaged completely by automation. RNAse ... Racked packaged 96 tips/rack and 10 racks/cs. ...
... racks of 96 tips, Sterilized Diamond- Tips ... Sterilized Diamond Tips are irradiated by gamma-rays ... with a certificate of sterilization, specifying the ... certified free of detectable Rnase, Dnase, DNA, ...
... Gilson disposable pipette tips, TowerPacks ... version. Each Sterilized TowerPack is ... plastic to help protect tips ... by the red sticker, which ...
... Like all Gilson disposable pipette ... a sterilized version. Each Sterilized ... medical device-quality plastic to help ... is guaranteed by the red ...
Medicine Products: