Navigation Links
Protein residues kiss, don't tell
Date:6/12/2012

Jos Onuchic has become an expert at connecting the dots, but finding connections merely implied by the dots well, that's quite a trick.

The Rice University biophysicist and his team have created a tool to do just that for proteins and, in the process, have advanced the art of predicting their form and function.

In this case, the dots are amino acid molecules known as residues that link together in chains to form proteins. Proteins are the workhorses that carry out the biological tasks essential to every living thing, but before they can go to work, they fold. Each protein has its own characteristic, folded shape, and various diseases, including cancer, have been linked to proteins that misfold or otherwise misbehave.

As computers grew more powerful over the past three decades, scientists have created many methods to predict how a particular chain of residues is likely to fold and the purpose the resulting protein serves.

Onuchic and colleagues at the Center for Theoretical Biological Physics have developed a tool, known as direct coupling analysis-fold (DCA-fold), that enhances existing methods. Details of their research appear today in the online version of the Proceedings of the National Academy of Sciences (PNAS). The center is currently based at the University of California at San Diego (UCSD) but is relocating to Rice's BioScience Research Collaborative.

While most protein-folding researchers look at the sequence of amino acids in a protein, either through X-ray crystallography of folded proteins or through computer simulations, Onuchic and his colleagues stepped back to look at the DNA sequences that serve as the blueprints for the proteins. By exploiting the increasingly large database of genomic sequence information, they're able to increase the accuracy of predicting the structures of folded proteins.

They start by finding points in the protein-encoding genome sequences that appear to
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Overexpression of proteins 14-3-3 related to chemotherapy resistance
2. Wayne State University researcher examines proteins role in diabetic retinopathy
3. New molecular structure offers first picture of a protein family vital to human health
4. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
5. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
6. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
7. Protein may represent a switch to turn off B cell lymphoma
8. RANK protein promotes the initiation, progression and metastasis of human breast cancer
9. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
10. Unusual protein helps regulate key cell communication pathway
11. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 18, 2015 Heritage Woods of McLeansboro, ... Supportive Living Week Celebration on April 20 with a ... healthy mind, body and soul. , The community, which ... serves older adults of all incomes, including those on ... , Supportive Living Week is observed every April and ...
(Date:4/17/2015)... 17, 2015 Alcohol and Violence , ... notes that drinking and driving has been the focus ... same time, the link between alcohol and crime received ... and violence and sexual assault, and their relationship to ... NCADD, 5.3 million adults in America were drinking alcohol ...
(Date:4/17/2015)... San Jose, CA (PRWEB) April 17, 2015 ... of life insurance protection without modifications can now use ... are now general life insurance policy rates that are ... . , The standard plans that are offered are ... for adults aged 18 to 79. There are now ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Most dental ... dental restoration units are made overseas by foreign dental ... domestic labs remain unregulated in more than 40 states ... National Association of Dental Laboratories has created ... raise awareness among patients about the consequences that could ...
(Date:4/17/2015)... CA (PRWEB) April 17, 2015 The American College ... event and Free Application Day on April 29. The event will ... Pioneer Square, located at 555 DeHaro St. in San Francisco, CA. ... a.m. – Check in at the DeHaro campus (room F), 11:10 ... Tour of campus, Noon – Light lunch with current students, faculty ...
Breaking Medicine News(10 mins):Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:National Association Urges Transparency in Dental Industry 2Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... has launched, dedicated to all aspiring souls with interest ... and wellness//. Founded by a personal fitness trainer turned ... inspired by her own healing process, it became the ... that educates, inspires, nurtures, and stimulates the mind, body, ...
... Thomas Jefferson University Hospital are combining efforts to determine if ... forms of migraine headaches. ,Investigators from the Jefferson ... in a blinded study to determine if closing a Patent ... allow blood to flow between the right and left sides ...
... Easter morning, two casual care support staff members allegedly assaulted ... Porirua//, New Zealand. Earlier another member of ... unit. All three are under suspension. ,Staff and ... under investigation from officials of the Capital and District Health ...
... Drug Administration (FDA) is alerting health care professionals and ... emerging// drug safety information. The broadcasts, commonly known as ... audio players. ,The service is part of ... communications concerning the safety of marketed medications when ...
... with the antiviral drug Tamiflu have the best chances of ... the World Health Organization (WHO) said on Friday. ... of international experts who met last month in Turkey to ... some countries to use steroids as well. ,"Corticosteroid ...
... exposed when thirty poor women of the fishing community, living ... The 1994 Transplant of Human Organ Act ... be allowed to donate kidneys for transplantation. However a recent ... to indicate that several leading hospitals in the state encouraged ...
Cached Medicine News:Health News:Jefferson Researchers Want to Learn If Heart Defect 'at Heart' of Some Migraines 2Health News:Mentally Ill Patients - Victims Of Assault By Their Caregivers 2Health News:FDA Announces Audio Broadcasts on Emerging Drug Safety Information 2Health News:Tamiflu Key to Treat Bird Flu, Avoid Steroids: WHO 2Health News:Kidney Trade: Curbing the Sale 2Health News:Kidney Trade: Curbing the Sale 3
(Date:4/17/2015)... Nonin Medical, a global leader in noninvasive medical monitoring, ... Steve Bucholz will retire May 1. Company founder ... Chief Executive Officer. In addition, Mr. Isaacson will continue ... transition to David Noel , Chief Financial Officer. ... to Nonin Medical,s growth," Mr. Isaacson said. "Under Steve,s ...
(Date:4/17/2015)... Apr. 17, 2015 Research and Markets ... of the "Medical Device Outsourcing - Global ... This report analyzes the worldwide markets ... the following Device Categories: Class I, Class II, ... in the report Include - Radiology, Orthopedic, Neurology, ...
(Date:4/17/2015)... , Apr. 17, 2015 Research and Markets ... the "Medical Equipment Rental and Leasing - Global ... This report analyzes the worldwide markets for Medical ... provides separate comprehensive analytics for the US, ... Rest of World. Annual estimates and forecasts ...
Breaking Medicine Technology:Nonin Medical's Philip Isaacson Expands CEO Role; President and COO Steve Bucholz to Retire May 1 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: