Navigation Links
Protein recognition and disorder: A debate
Date:1/11/2013

The extent to which three-dimensional structure is required for protein recognition and function is an area of vigorous debate with clear implications for protein engineering. Two differing viewpoints have been put forward in two articles published in F1000 Biology Reports today.

In structuring their arguments, the authors were encouraged to consider the opposing viewpoint, examine the points put forward and critique them in their own articles. This novel collaborative approach has given rise to a considered exchange of ideas and may consequently stimulate further research in the field.

In their article entitled "The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure", Keith Dunker (Indiana University School of Medicine) and Vladimir N. Uversky (Russian Academy of Sciences and University of South Florida) argue that the lock and key model of protein recognition cannot be upheld as a universal truth. They argue that some proteins without a rigid structure, intrinsically disordered proteins (IDPs), still have function.

In contrast, Jol Janin (Universit Paris-Sud) and Michael J.E. Sternberg (Imperial College, London), in their article "Protein flexibility, not disorder, is intrinsic to molecular recognition", argue that a protein's function in the real world environment of the body's cells is dependent on the structure of that protein, and that protein recognition requires regions of complementary structure binding to each other. Janin and Sternberg also note that many proteins seem to be disordered in the test tube but are in fact proteins waiting for partners (PWPs), which then adopt fully ordered structures in the presence of other components of the cell required to perform a function.

To counter the argument put forward by Janin and Sternberg, Dunker and Uversky conclude that the major difference between ordinary proteins and IDPs is that the former fold first and then bind to their partners while that latter remain disordered until they bind their partners. Furthermore, some IDPs can be much more dynamic than just "waiting for a partner", with the ability to switch from one partner to another and change structures while changing the partner.

Commenting on the two articles, Richard Henderson, MRC Laboratory of Molecular Biology, Cambridge said: "Both articles are by leaders who have given a great deal of thought to the function of proteins that appear to be intrinsically unfolded. Their different emphases will no doubt stimulate experiments as well as debate in the Structural Biology community. Time will tell us whether one or both models reflect how nature uses these structures."


'/>"/>

Contact: Eleanor Howell
press@f1000.com
44-020-763-19129
Faculty of 1000: Biology and Medicine
Source:Eurekalert

Related medicine news :

1. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
2. U-M sibling study discovers genetic region linked to control of key blood-clotting protein
3. New Greens and Protein Powders Help Supply Essential Nutrients
4. Strange behavior: New study exposes living cells to synthetic protein
5. Blood Protein Linked to Depression, Study Finds
6. Elevated levels of C-reactive protein appear associated with psychological distress, depression
7. Neuroscientists find excessive protein synthesis linked to autistic-like behaviors
8. Mealworms: The Next High-Protein Food Source?
9. Protein kinase Akt identified as arbiter of cancer stem cell fate
10. Pair of proteins gets brain cells into shape
11. Fast-acting enzymes with 2 fingers: Protein structurally and dynamically explained
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... Dallas, TX (PRWEB) , ... ... ... HCC Risk Adjustment solution leverages advanced data analytics to accurately understand each ... ensure proper reimbursement for a given population. This new solution helps transform ...
(Date:2/22/2017)... ... February 22, 2017 , ... Sideline Products participated in the ... national TV host Tom Seay and his production crew. Tom Seay’s program “Best ... around the world. Saddle Sidekicks will be featured on April 6, 2017. After ...
(Date:2/22/2017)... ... February 22, 2017 , ... ANGLESTRONG , the new ... now available on the App Store and Google Play . Florida-based ... the addiction and recovery industry, partnered with Angle to build ANGLESTRONG. The new recovery ...
(Date:2/22/2017)... , ... February 22, 2017 , ... A product of ... seem to derive a heart-protective benefit from eating soy foods, while others do not, ... men who are able to produce equol—a substance made by some types of “good” ...
(Date:2/22/2017)... GA (PRWEB) , ... February 22, 2017 , ... Super-Sod ... 25 and 26 event in Athens, Georgia. , A shift from Super-Sod’s simple Athens ... in Georgia. , For the booth, grass seed plant manager Chris Roquemore constructed furniture ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017  CTI BioPharma Corp. (CTI ... plans to report its fourth quarter and full year ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... to the event can be obtained as follows: ...
(Date:2/22/2017)... NORTHVALE, N.J. , Feb. 22, 2017  Andre, ... a technology-based developer and manufacturer of innovative technologies and ... financial results reported on February 21, 2017 in the ... www.sec.gov . ADMT CEO Andre, DiMino stated ... with our business plan by devoting a larger portion ...
(Date:2/22/2017)... -- Ultra Clean Holdings, Inc. (Nasdaq: UCTT), a leading ... for the semiconductor capital equipment, flat panel, medical, ... results for the fourth quarter and fiscal year ... a year of extraordinary growth for UCT. Total ... together with continued focus on operational excellence resulted ...
Breaking Medicine Technology: