Navigation Links
Protein recognition and disorder: A debate
Date:1/11/2013

The extent to which three-dimensional structure is required for protein recognition and function is an area of vigorous debate with clear implications for protein engineering. Two differing viewpoints have been put forward in two articles published in F1000 Biology Reports today.

In structuring their arguments, the authors were encouraged to consider the opposing viewpoint, examine the points put forward and critique them in their own articles. This novel collaborative approach has given rise to a considered exchange of ideas and may consequently stimulate further research in the field.

In their article entitled "The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure", Keith Dunker (Indiana University School of Medicine) and Vladimir N. Uversky (Russian Academy of Sciences and University of South Florida) argue that the lock and key model of protein recognition cannot be upheld as a universal truth. They argue that some proteins without a rigid structure, intrinsically disordered proteins (IDPs), still have function.

In contrast, Jol Janin (Universit Paris-Sud) and Michael J.E. Sternberg (Imperial College, London), in their article "Protein flexibility, not disorder, is intrinsic to molecular recognition", argue that a protein's function in the real world environment of the body's cells is dependent on the structure of that protein, and that protein recognition requires regions of complementary structure binding to each other. Janin and Sternberg also note that many proteins seem to be disordered in the test tube but are in fact proteins waiting for partners (PWPs), which then adopt fully ordered structures in the presence of other components of the cell required to perform a function.

To counter the argument pu
'/>"/>

Contact: Eleanor Howell
press@f1000.com
44-020-763-19129
Faculty of 1000: Biology and Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
2. U-M sibling study discovers genetic region linked to control of key blood-clotting protein
3. New Greens and Protein Powders Help Supply Essential Nutrients
4. Strange behavior: New study exposes living cells to synthetic protein
5. Blood Protein Linked to Depression, Study Finds
6. Elevated levels of C-reactive protein appear associated with psychological distress, depression
7. Neuroscientists find excessive protein synthesis linked to autistic-like behaviors
8. Mealworms: The Next High-Protein Food Source?
9. Protein kinase Akt identified as arbiter of cancer stem cell fate
10. Pair of proteins gets brain cells into shape
11. Fast-acting enzymes with 2 fingers: Protein structurally and dynamically explained
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... (PRWEB) May 23, 2013 Verndale, ... announce the launch of Current Digital, a business ... development and digital marketing needs. Companies now view ... strategic business necessity. This can often leave agencies ... strategy on preselected software platforms that they may ...
(Date:5/23/2013)... Worldwide Power Products (WPP), a power-generation equipment provider ... the rights to sell Hythane Company's OptiBlend™ ... mixture of natural gas and diesel. WPP will offer ... sale and rental and will also sell retrofitting services ... technicians will be certified to install the conversion kits ...
(Date:5/23/2013)... 23, 2013 According to the ... one cause of death in America today and is the ... More than 400,000 women die in the United States each ... minute. Seven factors are considered to profile the status of ... list. Many people are under the false assumption that if ...
(Date:5/23/2013)... 23, 2013 The Assault Hand ... a major milestone in its corporate development. After ... the release of the Assault Hand Paddle is an ... The Assault Hand Paddle is “revolutionizing paddle sportsmen’s stealth ... paddle sportsmen seeking stealth and close quarter mobility. ...
(Date:5/23/2013)... With crowded gyms, bodyweight workouts and ... to Mike Whitfield, a bodyweight expert in the Atlanta, ... medicine ball can add a whole new dynamic to ... website in which anyone can download a 4-week bodyweight ... he shared a video with his subscribers showing the ...
Breaking Medicine News(10 mins):Health News:Verndale Launches Current Digital, a Technology Partner for Ad and Creative Agencies 2Health News:Verndale Launches Current Digital, a Technology Partner for Ad and Creative Agencies 3Health News:Worldwide Power Products Announces Partnership with Hythane Company to Offer OptiBlend™ Bi-Fuel Solution for Diesel Engines 2Health News:Worldwide Power Products Announces Partnership with Hythane Company to Offer OptiBlend™ Bi-Fuel Solution for Diesel Engines 3Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Safe and Healthy New Fast Weight Loss Alternative for At-Risk Heart Disease Patients 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Safe and Healthy New Fast Weight Loss Alternative for At-Risk Heart Disease Patients 3Health News:The Assault Hand Paddle Revolution is On 2Health News:The Assault Hand Paddle Revolution is On 3Health News:Unique Ab Exercise, the Medicine Ball Chop, Released from BodyweightTorch.com 2
... the children’s hospital Boston, a surgery was conducted on a baby ... stent procedure in the womb. // She was discharged on Friday ... was diagnosed with a heart defect called hypoplastic left heart syndrome ... placed a stent in the developing fetus on November 7, 2005. ...
... in a hospital at Brisbane a patient had to be ... attacked and was in serious condition, attention could not be ... Hospital, where emergency services are scarce due to shortage of ... operational from 8am to 6pm every day. ,The ...
... largest drug maker, Pfizer has announced that it intends to ... regulatory approvals from the US Food and Drug Administration ... been developed in collaboration with Sanofi-Aventis and Nektar Therapeutics. ... that no needles or pens or syringes are needed. "Until ...
... Robert Hill, a Crohn’s patient has successfully reached the ... climb began // on January 12th and was successfully ... and sub-freezing temperatures. ,He was a strong, ... and ulcerative colitis. During the course of the disease ...
... of stress on the pregnant women. ... stress and people are in search for a remedy for it. // ... number of pregnant women approaching the health care centers for a treatment ... a need to include new information about the management of stress during ...
... Cyprus are reported to be infected with the H5N1 strain, ... European Union country, even though the EU rules remain suspended ... where the infection was detected attracts as many as 1 ... the virus is said to be the same that claimed ...
Cached Medicine News:Health News:Baby Underwent A Heart Surgery Inside The Womb 2Health News:Crohn's Patient Robert Hill’s greatest achievemen 2
(Date:5/22/2013)... 2013  Aribex, Inc., manufacturer of the newly released ... new color option, black with gray trim, of the ... markets. The popular white with light blue trim Pro ... be available and both models can be purchased from ... http://photos.prnewswire.com/prnh/20130522/CL19573 ) "Dental offices are adding ...
(Date:5/22/2013)... , May 22, 2013 Attorney ... potential claims on behalf of purchasers of the ... "Company") (NasdaqGS: AMAG -News).  The investigation focuses on ... securities laws. On May 22, 2013, ... intraday trading after the company announced in regulatory ...
(Date:5/22/2013)... and CAESAREA, Israel , May 22, ... New clinical data presented from the DEFLECT-I study demonstrates ... reduces brain lesion volume during TAVR (Transcatheter Aortic Valve ... Keystone Heart Scientific Advisory Board announces consensus on the ... regarding the importance and need for cerebral protection during ...
Breaking Medicine Technology:Aribex Unveils New Color of NOMAD Pro 2 2Bronstein, Gewirtz & Grossman, LLC Announces Investigation of AMAG Pharmaceuticals, Inc. 2New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 2New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 3New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: