Navigation Links
Protein pushes breast cancer cells to metastasize
Date:7/9/2014

A telling the cell to destroy it, for instance. "These structural differences help determine RNA's fate, by exposing or hiding the binding sites for those key proteins," says Goodarzi.

So Goodarzi and Saeed Tavazoie developed a computer algorithm that scans samples of cancer cells and identifies patterns in the shapes and sequences of RNA. In the current study, the authors applied this algorithm to breast cancer cells. In cells prone to metastasis, for example, the scientists found certain RNA hairpin loops that were overrepresented in the sequences of RNAs targeted for destruction. They then identified a protein that binds to those hairpin sequences TARBP2, known to play a role in the formation of small RNAs known as microRNAs. But here, it appears TARBP2 can also act as a "master regulator" of RNA itself, by binding to multiple sites and causing a suite of changes that lead to metastasis including the destruction of the RNAs that carry those key binding sites. Indeed, they found that TARBP2 is overexpressed in cells prone to metastasizing, as well as in metastatic human breast tumors themselves.

To determine how TARBP2 carries out its effects, the researchers looked at which genes appear to be downregulated in metastatic cell lines, reasoning that TARBP2 may block these disease suppressors. They made two surprising discoveries APP, a protein linked to Alzheimer's disease, and ZNF395, which is associated with Huntington's disease, are both downregulated by TARBP2. Cells prone to metastasis showed higher levels of TARBP2 and lower levels of APP and ZNF395; in cancer cells that tend not to spread throughout the body, the opposite was true.

"This was a surprising finding, because these genes are normally associated with neurodegeneration are now implicated in breast cancer metastasis and progression," says Tavazoie. "It's interesting that these totally disparate disease processes have a potential molecular link. We don't know what that m
'/>"/>

Contact: Franklin Hoke
fhoke@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NUS researchers discover novel protein complex with potential to combat gastric cancer
2. Mechanism discovered for attaching an on switch that helps cells accessorize proteins
3. Proteins causing daytime sleepiness tied to bone formation, target for osteoporosis
4. Viral infections, including flu, could be inhibited by naturally occurring protein
5. Fungal protein found to cross blood-brain barrier
6. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
7. Atomic structure of essential circadian clock protein complex determined
8. Compounds in saliva and common body proteins may fend off DNA-damaging chemicals
9. Penn study shows how misfolded proteins are selected for disposal
10. RaDAR guides proteins into the nucleus
11. TSRI scientists catch misguided DNA-repair proteins in the act
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... 02, 2015 For those that have ... exposed to harmful germs, chemicals and bodily fluids from ... to an inventor from Queens Village, N.Y., their worries ... an efficient, fun, hygienic way to store and dispense ... to bugs, chemicals and germs. Furthermore, it insures that ...
(Date:6/2/2015)... NC (PRWEB) June 02, 2015 ... training and compliance solutions for the healthcare market, ... The Arc to offer 10 complimentary courses relating ... provide public safety professionals with additional resources to ... Safety professionals are often the first responders to ...
(Date:6/2/2015)... 02, 2015 Recent findings from the ... while there has been a reduction in conventional cigarette ... waterpipe vapor (hookah) usage has doubled among today’s teens ... Russell Gombosi believes the national trend is consistent with ... 15 to 20 years to fully determine the long-term ...
(Date:6/2/2015)... Glidewell Laboratories, industry-leading provider of ... the new issue of Chairside® magazine, its restorative-dentistry-focused ... The digital edition of the latest issue, Volume ... of the dental laboratory’s magazine, can be viewed ... by visiting http://www.chairsidemagazine.com . , In the ...
(Date:6/2/2015)... 02, 2015 Residents of Monarch Landing ... swim, take a fitness class, do yoga, play volleyball, ... In preparation for the Alzheimer’s Association’s Walk to End ... will take part in a challenge to exercise for ... Landing’s management company. , While the walk will raise ...
Breaking Medicine News(10 mins):Health News:Dental Storage and Dispensing Unit Invented by InventHelp Client (LGI-1890) 2Health News:Relias Learning Partners with Behavioral Health and Developmental Disabilities Leaders to Offer Complimentary Resources to Public Safety Professionals 2Health News:Relias Learning Partners with Behavioral Health and Developmental Disabilities Leaders to Offer Complimentary Resources to Public Safety Professionals 3Health News:Susquehanna Health Pediatrician Warns of Adverse Effects of Teen E-Cigarette Usage 2Health News:Susquehanna Health Pediatrician Warns of Adverse Effects of Teen E-Cigarette Usage 3Health News:Glidewell Laboratories Releases New Issue of Restorative Dentistry Magazine Chairside in Print and Online 2Health News:Glidewell Laboratories Releases New Issue of Restorative Dentistry Magazine Chairside in Print and Online 3Health News:Monarch Landing Takes 60-Day Exercise Challenge to Combat Alzheimer’s 2Health News:Monarch Landing Takes 60-Day Exercise Challenge to Combat Alzheimer’s 3
... intimate partners spent 42 percent more on health care per ... more than 3,000 women. , And the costs don,t end ... suffered physical abuse five or more years earlier still spent ... who were never abused. , "Along with all the physical ...
... Services, Inc. announced today that it has provided ... Hospital in Mountain View, California. The five-year tax-exempt ... Siemens Medical Solutions equipment which will be deployed ... http://www.newscom.com/cgi-bin/prnh/20070904/SIEMENSLOGO )"For more than 40 years, ...
... Kiley Carlson of Sioux City, IA will travel to ... 2009 to meet with congressional leaders and gain their ... toward a cure for epilepsy.Carlson, 16, is one of ... Kids Speak Up! , a national program coordinated ...
... 23 Fujirebio Diagnostics, Inc., the premier cancer ... biomarker assays, today announced the appointment of Grady ... Barnes comes to Fujirebio Diagnostics with 25 years ... positions at Abbott and Meridian Bioscience, most recently ...
... demonstrated how a single-celled organism, living freely in the ... transmission to animals and humans. , Salmonella ... food type, causing diarrhoea, abdominal pain and fever. ... also cause typhoid fever has evolved unique mechanisms ...
... access to largest portfolio of clinical laboratory ... Healthcare ( www.siemens.com/diagnostics ) and Sysmex Corporation ... of a five-year contract renewal for a ... Under the agreement, clinical laboratory customers around ...
Cached Medicine News:Health News:Physical abuse raises women's health costs over 40 percent 2Health News:Siemens Financial Services, Inc. Announces Completion of Tax-Exempt Financing With El Camino Hospital 2Health News:Siemens Financial Services, Inc. Announces Completion of Tax-Exempt Financing With El Camino Hospital 3Health News:Iowa Youth Shares Epilepsy Message on Capitol Hill 2Health News:Fujirebio Diagnostics Appoints Grady Barnes as Chief Scientific Officer 2Health News:Study shows how Salmonella survives in environment 2Health News:Siemens and Sysmex Renew Global Agreement 2Health News:Siemens and Sysmex Renew Global Agreement 3
(Date:6/2/2015)... , June 2, 2015 San MediTech, the ... continuous glucose monitoring (CGM) for diabetics, announced its plan ... Sessions in Boston on June ... their newest Dynamic Glucose Monitoring System (DGMS). The company ... the world the innovative technologies and advancements made by ...
(Date:6/2/2015)... Mass. , June 2, 2015  PROMETRIKA, ... expanded its offerings with the addition of pharmacovigilance ... a world leader in safety data collection and ... and regulatory affairs professionals, and expert physicians, each ... provide clinical interpretation and monitoring of safety trends. ...
(Date:6/2/2015)... June 2, 2015  Psychemedics Corporation (NASDAQ: PMD ... twenty-five years, announced the addition of 2 new drugs ... growing abuse concerns, the addition of Oxymorphone was made ... added as an option to the Amphetamine panel. ... stated:  "Sadly, more and more prescription drugs are being ...
Breaking Medicine Technology:San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 2San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 3San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 4PROMETRIKA Announces the Availability of Pharmacovigilance Services 2Psychemedics Announces Addition Of FDA Cleared Drugs 2Psychemedics Announces Addition Of FDA Cleared Drugs 3
... on the success of their revolutionary soft cloth nasal ... proud to introduce a mask tube so lightweight and ... Used in the treatment of sleep apnea, ... the CPAP mask with a 15-millimeter hose composed of ...
... 2011 Ampio Pharmaceuticals, Inc. (NASDAQ: ... that discovers and develops new uses for previously ... announced that an IRB approved, randomized, vehicle-controlled, double-blinded ... in Denver, Colorado indicates that Ampion™ provides safe ...
Cached Medicine Technology:Circadiance Launches Revolutionary New CPAP Tube 2Ampio Pharmaceuticals Announces Positive Results on Ampion™ Trial for Relief of Nasal Inflammation 2Ampio Pharmaceuticals Announces Positive Results on Ampion™ Trial for Relief of Nasal Inflammation 3
... a monoclonal antibody based colorimetric test ... Neisseria gonorrhoeae. The test requires less ... no heating or pretreatment. The test ... fresh cultures. GonoGen&trade II eliminates agglutination, ...
Culture Confirmation Tests...
... GC is a novel device for ... Neisseria gonorrhoeae and Neisseria meningitidis. ... life and is easily transportable as ... inoculate, incubate and examine the growth ...
... (Nidek Advanced Vision Information System) is an ... software on a platform designed to communicate ... The network can be expanded in various ... to Nidek products but also to fundus ...
Medicine Products: