Navigation Links
Protein pushes breast cancer cells to metastasize
Date:7/9/2014

A telling the cell to destroy it, for instance. "These structural differences help determine RNA's fate, by exposing or hiding the binding sites for those key proteins," says Goodarzi.

So Goodarzi and Saeed Tavazoie developed a computer algorithm that scans samples of cancer cells and identifies patterns in the shapes and sequences of RNA. In the current study, the authors applied this algorithm to breast cancer cells. In cells prone to metastasis, for example, the scientists found certain RNA hairpin loops that were overrepresented in the sequences of RNAs targeted for destruction. They then identified a protein that binds to those hairpin sequences TARBP2, known to play a role in the formation of small RNAs known as microRNAs. But here, it appears TARBP2 can also act as a "master regulator" of RNA itself, by binding to multiple sites and causing a suite of changes that lead to metastasis including the destruction of the RNAs that carry those key binding sites. Indeed, they found that TARBP2 is overexpressed in cells prone to metastasizing, as well as in metastatic human breast tumors themselves.

To determine how TARBP2 carries out its effects, the researchers looked at which genes appear to be downregulated in metastatic cell lines, reasoning that TARBP2 may block these disease suppressors. They made two surprising discoveries APP, a protein linked to Alzheimer's disease, and ZNF395, which is associated with Huntington's disease, are both downregulated by TARBP2. Cells prone to metastasis showed higher levels of TARBP2 and lower levels of APP and ZNF395; in cancer cells that tend not to spread throughout the body, the opposite was true.

"This was a surprising finding, because these genes are normally associated with neurodegeneration are now implicated in breast cancer metastasis and progression," says Tavazoie. "It's interesting that these totally disparate disease processes have a potential molecular link. We don't know what that m
'/>"/>

Contact: Franklin Hoke
fhoke@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NUS researchers discover novel protein complex with potential to combat gastric cancer
2. Mechanism discovered for attaching an on switch that helps cells accessorize proteins
3. Proteins causing daytime sleepiness tied to bone formation, target for osteoporosis
4. Viral infections, including flu, could be inhibited by naturally occurring protein
5. Fungal protein found to cross blood-brain barrier
6. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
7. Atomic structure of essential circadian clock protein complex determined
8. Compounds in saliva and common body proteins may fend off DNA-damaging chemicals
9. Penn study shows how misfolded proteins are selected for disposal
10. RaDAR guides proteins into the nucleus
11. TSRI scientists catch misguided DNA-repair proteins in the act
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Scooter Direct is now offering Pride Go Go Traveller ... $929.00, marked down from the MSRP of $1605.00. Scooter ... offering quality mobility solutions to its clients. The online ... chairs, and their accessories at unbeatable prices. ... Traveller Elite, a senior store manager stated, “Electric mobility ...
(Date:4/27/2015)... On the top floor of the luxurious Beverly ... Los Angeles, CA, Per Wickstrom had an in-depth conversation ... of Orange County” Gretchen Christine Rossi. , In ... “Salute to the Oscars” celebration, sponsored by Choices Recovery, ... Wickstrom, Rossi felt that the evening’s interviews would not ...
(Date:4/27/2015)... 27, 2015 The WeedLife Network ... a problem that has been troubling cannabis businesses ... by announcing the launch of WeedLIVE, the ... , Officially launched today, WeedLIVE.com is designed ... to index only marijuana-related business websites. , WeedLIVE ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 Pure n ... of its brand new website design at http://www.purennatural.com/ ... of the company’s product catalog, both featured and sale ... blog ( http://www.purennatural.com/blog/ ). , Pure n Natural Systems’ ... satisfying shopping experience. The website is neatly organized and ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 PREVENT Life ... expanding its Texas operations with the addition of an ... life safety services to a growing customer base, Curtis ... as a new Senior Account Manager. Curtis has been ... support existing customers throughout the Houston area and beyond. ...
Breaking Medicine News(10 mins):Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 3Health News:Per Wickstrom Shares His Vision of Choices Recovery with Reality TV Star Gretchen Christine Rossi 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 3Health News:Pure n Natural Systems, Inc. Launches New Website Design 2Health News:Pure n Natural Systems, Inc. Launches New Website Design 3Health News:PREVENT Life Safety Services Welcomes Curtis Rice as a New Senior Account Manager in Houston, TX 2
... joined the protesting medical students on Saturday in the ... Azad Medical College and ended at the Jantar Mantar. ... no sloganeering. The participants also formed a human chain, ... “We do not want to inconvenience anybody. We are ...
... of tsunami-hit Pondicherry beach on Saturday to create a sculptor ... Child' - spreading the message of polio eradication was unveiled ... sculpture with two polio drops to mark the last phase ... ,Thousands of tourists, among them many foreigners, thronged ...
... study conducted, researchers highlight that surgeons can now remove ... facial nerve is not injured//. This study, which investigates ... to describe where and how often the facial nerve ... provide surgeons with adequate knowledge, helping them prevent a ...
... tonsils and adenoids does not result in a compromise ... new study has found. The findings of the present ... pain-free and effective method to remove tonsils and adenoids ... have been discouraged from having monopolar electrosurgery for ear, ...
... the popular belief that only bad dogs bite, it has ... pain can bite, argue pediatricians//. Doesn’t sound alarming? According to ... dogs bite nearly 4.7 million Americans every year. ... 14 years of age and 150,000 of these bites are ...
... ahead and purchased a medical equipment from an internet ... the hospital authorities. Apparently, he had already purchased ?45,000 ... Paget Hospital, Gorleston, Norfolk. A retractor, which was much ... huge order. ,Since a retractor is critical ...
Cached Medicine News:Health News:Study Offers Hope In Prevention Of Facial Paralysis 2Health News:Electrosurgery Ensures Integrity Of Cochlear Implant Following Adenoids Removal 2Health News:Electrosurgery Ensures Integrity Of Cochlear Implant Following Adenoids Removal 3Health News:Watch Out! Even Good Dogs Can Bite Your Kids 2
(Date:4/24/2015)... 24, 2015  Bayer Corporation hosted its annual "Take Your ... Bayer HealthCare US headquarters.  This is Bayer,s second "Take Your ... Whippany campus, and Thursday,s event welcomed 230 children ... at work. Fortunately, for the kids, this was ... whose mission is "Science For A Better Life," Bayer made ...
(Date:4/24/2015)... , April 24, 2015 In today,s ... employee groups around the world to access diverse ... hours. While there are many areas to misstep ... examine which best practices are necessary and beneficial ... According to research by benchmarking firm, ...
(Date:4/24/2015)... and Markets ( http://www.researchandmarkets.com/research/pmbmv2/global_biobanking ) has announced ... report to their offering. The analysts ... CAGR of 7.07% over the period 2014-2019 ... segments: Equipment and Consumables. This report covers the present ... market for the period 2015-2019. ...
Breaking Medicine Technology:Bayer Hosts "Take Your Child to Work Day" 2Bayer Hosts "Take Your Child to Work Day" 3Bayer Hosts "Take Your Child to Work Day" 4Work Around the Clock: Building Effective Global Capabilities 2Global Biobanking Market Report 2015-2019 - Increase in Strategic Collaborations with Beckman Coulter, Tecan & Thermo Fischer Scientific Dominating 2
... May 2, 2011 NewCardio, Inc., (OTC BB: NWCI) a ... prestigious NYC Bright Lights Conference at the Le Parker Meridien ... of its kind with an exclusive focus on publicly traded ... will present on May 10, 2011 at 9 a.m. ET. ...
... Fla., May 2, 2011 The Unilens Vision Inc. ... of Directors today declared a quarterly cash dividend of $0.045 per ... record at the close of business on May 13, 2011. ... Specialty Contact Lens Company" Established in 1989, Unilens ...
Cached Medicine Technology:NewCardio to Showcase Cardiac Diagnostic Technology at MDB Capital's Bright Lights Conference in New York City on May 10, 2011 2NewCardio to Showcase Cardiac Diagnostic Technology at MDB Capital's Bright Lights Conference in New York City on May 10, 2011 3NewCardio to Showcase Cardiac Diagnostic Technology at MDB Capital's Bright Lights Conference in New York City on May 10, 2011 4Unilens Vision Inc. Declares Quarterly Cash Dividend of $0.045 Per Share 2
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
... ,Offers an average 5:1 increase in usage ... use of a standard cannula. , ,The ... offers ambulatory oxygen patients a superior alternative to ... 2-year warranty. , ...
Redesigning the World's Oxygen Therapy One Device at a Time. , ,Everything you like about our OXYMATIC 400 Series conservers, only better!...
Medicine Products: