Navigation Links
Protein protects against breast cancer recurrence in animal model
Date:6/13/2013

ch is turned on in about 20% of human breast cancers -- induces the formation of a primary mammary tumor. Subsequently, turning HER2/neu "off" in a tumor that has arisen causes it to essentially disappear, mimicking the treatment of primary human breast cancers with the anti-HER2/neu agent, Herceptin. But, as in many human patients, at some point in the weeks and months following tumor regression, tumors often return, both in the breast as well as in secondary sites such as the lungs.

By studying these paired primary and recurrent tumors, Alvarez, Chodosh, and their colleagues found that Par-4 expression was dialed down in recurrent tumors relative to primary tumors. When they examined gene expression data from human breast cancer specimens, they found that low Par-4 expression was associated with an increased risk of recurrence and a poorer response to neoadjuvant therapy -- chemotherapy prior to surgery. A poor response to neoadjuvant therapy is associated with an increased likelihood of recurrence.

Based on these findings, the team hypothesized that cells that downregulate Par-4 may be more adept at surviving chemotherapeutic treatment of the primary tumor, and that's precisely what they found. When they compared cells expressing normal levels of Par-4 with cells that had downregulated the gene, they found that it is the cells with low Par-4 levels that persist following treatment. Consequently, it is these cells that are available to give rise to recurrent tumors in the future.

The team then asked what Par-4 actually does to prevent breast cancer recurrence. They found in their mouse models that when HER2/neu is turned off and primary tumors shrink, Par-4 expression ramps up. This causes a defect in cell division, producing cells with more than one nucleus. This, in turn, leads to cell death. Cells that have downregulated Par-4 fail are able to escape this multinucleation process, allowing them to survive therapy and, eventually, gi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Drug and alcohol addiction is ... abuse has claimed thousands of lives throughout the region. ... hope for teenagers who are seeking to overcome their ... to provide adolescents and their parents with guidance, support ... youth rehab facility to meet their specific needs. ...
(Date:8/22/2014)... According to the market research report "Blind ... (ACC) System Market for Passenger Cars; by Geography ... by MarketsandMarkets, classifies and defines the automotive BSD ... and value. The report highlights potential growth opportunities ... review of the market drivers, restrains, growth indicators, ...
(Date:8/21/2014)... New York (PRWEB) August 22, 2014 ... for the Long Island region, proudly announces the launch ... site, focused on the West Babylon-based yoga studio’s new ... who wish to become teachers realize their dreams. , ... community and those living in the surrounding area a ...
(Date:8/21/2014)... Florida Hospital Zephyrhills is the ... the only in the Tampa Bay area to ... Olympus Endoalpha Universal Platform for surgical endoscopy. The ... specialties, and provides the hospital a standardized solution ... and patient care. Surgical endoscopy systems, through the ...
(Date:8/21/2014)... 21, 2014 August 11: – Robin ... own life by hanging, likely due to long-term depression. ... the foremost BioAcoustic Vocal Profiling investigator, appeared on the ... concerning Williams’ death; hoping to help people understand why ... to Williams’ suicide were proposed in terms of BioAcoustic ...
Breaking Medicine News(10 mins):Health News:Substance Abuse Helpline Provides Hope for Teens & Parents in Brunswick, OH 2Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 2Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 3Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 4Health News:Yoga Darshana Center Announces Launch of New Website LongIslandYogaTeacherTraining.com 2Health News:Florida Hospital Zephyrhills is Elevating Healthcare by Offering the First Olympus Fully-Integrated HD Operating Room in Pasco County 2Health News:Florida Hospital Zephyrhills is Elevating Healthcare by Offering the First Olympus Fully-Integrated HD Operating Room in Pasco County 3Health News:Robin Williams: What he could not bear to face 2Health News:Robin Williams: What he could not bear to face 3
... Dental Network of America,Inc. (DNoA), announces double digit growth ... DNoA Preferred Network -- now totaling over 120,000,dentist access points ... network growth places DNoA as the largest dental network,in terms ... as of,September 2008, powered by The Ignition Group,( http://www.theignitiongroup.net ). ...
... Premier Net-Centric Alert and Notification Technology Company today announces the ... Medical Center. , ... Washington, D.C. ... a Premier Net-Centric Alert and Notification Technology Company, today announces ...
... the Dec. 15 issue of the Journal of Clinical ... clinical picture of comorbid conditions associated with obstructive sleep apnea ... interrelationships. , Results show that the number of cases ... low during adolescence, and then rises from 25-29 years to ...
... new therapeutic target for pancreatic cancer, the most lethal ... proteins whose DNA recipe comes from gene, "Seven-In-Absentia," according ... (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San ... fly, Drosophila melanogaster, at the Mayo Clinic College of ...
... of year, experts say , , SUNDAY, Dec. 14 (HealthDay News) ... many, it can cause depression for seniors who,ve lost loved ... some seniors, this despondency can lead to suicide, according to ... rate for Americans over the age of 65 was 14 ...
... a Sales Kaizen event to Improve Your Sales Process in a Way ... GA. A teleconference introducing the book will be held on Dec 18, ... ... 2008 -- Companies everywhere are struggling to find ways of generating more ...
Cached Medicine News:Health News:Dental Network of America Becomes Largest National Dental Network in the U.S. 2Health News:Berkshire Medical Center Selects Desktop Alert for Mass Notification Solutions 2Health News:Berkshire Medical Center Selects Desktop Alert for Mass Notification Solutions 3Health News:Berkshire Medical Center Selects Desktop Alert for Mass Notification Solutions 4Health News:Data mining of inpatient records reveals the disease pattern of obstructive sleep apnea 2Health News:Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer 2Health News:Helping Seniors Beat the Holiday Blues 2Health News:New Guidebook Published for Improving B2B Sales Results in 90 Days or Less Through Kaizen Events 2Health News:New Guidebook Published for Improving B2B Sales Results in 90 Days or Less Through Kaizen Events 3
(Date:8/21/2014)... 2014  ACI Clinical ( www.aciclinical.com ) announces ... Committees. Using this solution, trial sponsors ... standard costs and receive the same expertise that ... services. Leveraging a decade of DMC ... development, statistical programming and meeting facilitation), ACI analyzed ...
(Date:8/21/2014)... 2014  Armada Health Care (Armada), the nation,s ... pleased to announce an agreement with Aurora Health ... innovative specialty pharmacy patient program offerings. The new ... services to specialty patients via Armada,s proprietary ReachRx ... will use the OTM platform as its case ...
(Date:8/21/2014)... 2014  The board of directors of VirtualScopics, Inc. ... clinical trial imaging solutions, today announced that James ... effective immediately.  Mr. Groff has held the role of ... VirtualScopics in January 2006 as an accounting manager and ... "When the board of VirtualScopics asked Jim to assume ...
Breaking Medicine Technology:ACI Clinical: Innovation and Savings in Data Safety Monitoring Committees 2Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 2Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4
... one step fixation of soft tissue to bone. ... cuff repair in one simple insertion maneuver. The ... of 5 mm and a small 2 mm ... hold a thin, bioabsorbable PLLA disc 5 mm ...
... bioabsorbable push-in suture anchor with a molded-in suture ... in the shoulder joint and other indications where ... is required. The exclusive braided suture eyelet loop ... and provides superior resistance to suture abrasion compared ...
TigerStick is a white #2 FiberStick with black stripes and a stiffened, 12 inch, waxed end. It is especially useful when motion determination and alternating colored sutures are required in the arthr...
... Flowmaster. It is a new portable digital flowmeter ... of use, simplicity and cost effectiveness are top ... now very easy to give a patient some ... and data will be send wirelessly to the ...
Medicine Products: