Navigation Links
Protein protects against breast cancer recurrence in animal model
Date:6/13/2013

PHILADELPHIA - According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence the reappearance of the disease following treatment.

Precisely what causes breast cancer recurrence has been poorly understood. But now a piece of the puzzle has fallen into place: Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy. They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse.

The findings appear in this week's issue of Cancer Cell.

The study was led by Chodosh senior postdoctoral fellow, James V. Alvarez, PhD. Alvarez and his colleagues teased apart the role of Par-4 using a mouse model of recurrent breast cancer. In this model, turning "on" the HER2/neu oncogene in mice -- whi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Parsippany, NJ (PRWEB) July 31, 2014 A ... millions of people survive cancer and resume normal lives. This ... American Cancer Society, will affect one in seven American men ... are, has a five-year survival rate of nearly 100% and ... serious illness but most men diagnosed with the disease do ...
(Date:7/31/2014)... its latest blog post, Best Drug Rehabilitation , which ... during a stay in rehab can make a big difference ... at 11 drug addiction facts that children aren’t taught in ... some kids learn a little about the dangers of alcohol ... woefully inadequate,” commented Best Drug Rehabilitation’s Per Wickstrom . ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Continuing ... the upcoming inaugural Clinical Issues in Primary Care ... October 13-17, 2014 at the Wailea Beach Marriott Resort ... agenda has been developed for today's Primary Care ... critical CME topics," says Barbara Lyons, VP Education. , ...
(Date:7/31/2014)... 31, 2014 Nuanced Media, a leading ... of the Nuanced Medical website . Nuanced Medical, ... needs of the Medical Industry. , The idea behind ... for medical practices to meet continuously changing federal regulations. ... HIPAA Act (Health Insurance Portability and Accountability Act), which ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 The ... with the Penn's Abramson Cancer Center, will host a ... together area experts in the field of mesothelioma. September ... The conference is open to the public, and specifically ... and those who have been exposed to asbestos. , ...
Breaking Medicine News(10 mins):Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 2Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 3Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 4Health News:New Best Drug Rehabilitation Blog Posts Looks at 11 Drug Addiction Facts they Don’t Teach in School 2Health News:Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released 2Health News:Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released 3Health News:Nuanced Media, HIPAA Certified Agency, Launches Medical Web Design Service Website 2Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 2Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 3
... Blacks 45 percent more likely to die from the disease ... News) -- Despite major progress reducing overall colorectal cancer incidence ... women are still 45 percent more likely than whites to ... a report released Monday by the American Cancer Society. , ...
... of Oregon lab have shed more light on the ... in which a methyl group is attached to DNA, ... , DNA methylation is essential for normal growth and ... in long-term memory, and irregularities in its process are ...
... The Cardiopulmonary Research Science,and Technology Institute (CRSTI), ... for a Phase 2 clinical trial for ... of,Gene Therapy in Cardiac Disease" (CUPID Trial) ... at the American Heart Association Scientific,Sessions 2008. ...
... food costs, many,families are economizing on groceries but one thing ... cents per 8-ounce glass, on a gallon basis, milk,offers more ... the,supermarket -- proving key vitamins and minerals like calcium and ... moms don,t cut milk from,their grocery lists, the National got ...
... CORPUS CHRISTI, Texas, Dec. 15 With rising food costs,many ... not cut,back on is nutrition. At about 25 cents per ... penny than almost any other beverage option in,the supermarket -- ... are important for the entire family. To ensure moms don,t ...
... Dec. 15 With rising food costs, many,families are ... cut back,on is nutrition. At about 25 cents per ... per penny than almost any other beverage option in ... and vitamin D,that are important for the entire family. ...
Cached Medicine News:Health News:Colorectal Cancer Racial Gap Still Growing 2Health News:Work with fungus uncovering keys to DNA methylation 2Health News:CRSTI and Medical City Hospital Dallas Currently Recruiting For a Phase 2 Clinical Trial of MYDICAR(R) for Advanced Heart Failure 2Health News:CRSTI and Medical City Hospital Dallas Currently Recruiting For a Phase 2 Clinical Trial of MYDICAR(R) for Advanced Heart Failure 3Health News:CRSTI and Medical City Hospital Dallas Currently Recruiting For a Phase 2 Clinical Trial of MYDICAR(R) for Advanced Heart Failure 4Health News:Milk is One Beverage Kansas City Can't Afford to Keep Off the Grocery List 2Health News:Milk is One Beverage Kansas City Can't Afford to Keep Off the Grocery List 3Health News:Milk is One Beverage Corpus Christi Can't Afford to Keep Off the Grocery List 2Health News:Milk is One Beverage Corpus Christi Can't Afford to Keep Off the Grocery List 3Health News:Milk is One Beverage Birmingham Can't Afford to Keep Off the Grocery List 2Health News:Milk is One Beverage Birmingham Can't Afford to Keep Off the Grocery List 3
(Date:7/30/2014)... CryoLife, Inc. (NYSE: CRY), a leading medical ... vascular surgery, announced today that its Board of Directors ... quarter 2014 of $0.03 per share of common stock ... will be paid on September 19, 2014 to all ... The ex-dividend date for the quarterly dividend is September ...
(Date:7/30/2014)... 30, 2014 PuraMed BioScience ® , ... over-the-counter (OTC) medicinal and healthcare products, announced today ... name along with the name,s red and yellow ... trademarked name MigraPure ®  going forward. The ... homeopathic, natural migraine pain reliever will be reintroduced ...
(Date:7/30/2014)... 30, 2014  El Camino Hospital, a leader in ... utilizing the Leaf Patient Monitoring system to help prevent ... of patients susceptible to bed sores. The ... study of the system, which showed dramatic improvement in ... regularly is the one of the most effect ways ...
Breaking Medicine Technology:CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 2CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 3PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 3El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3
Semi-Automated Chemistry Analyzer with model screen master. The Screen Master incorporates many powerful features in one compact unit. Useful for biochemical investigations, enzymatic, immunoturbidi...
... Geometric Data Hemastainer. Formulated to ... quality control tested on human ... staining and absence of precipitate. ... a minimum of eight hours ...
... Unique molecular suspension in methanol for ... chromosome, and histology smears. Our special ... rapidly penetrates cellular elements producing unequaled ... detail and unexcelled brilliance in the ...
Wright-Giemsa Stain Solutions...
Medicine Products: