Navigation Links
Protein protects against breast cancer recurrence in animal model
Date:6/13/2013

PHILADELPHIA - According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence the reappearance of the disease following treatment.

Precisely what causes breast cancer recurrence has been poorly understood. But now a piece of the puzzle has fallen into place: Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy. They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse.

The findings appear in this week's issue of Cancer Cell.

The study was led by Chodosh senior postdoctoral fellow, James V. Alvarez, PhD. Alvarez and his colleagues teased apart the role of Par-4 using a mouse model of recurrent breast cancer. In this model, turning "on" the HER2/neu oncogene in mice -- whi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Internationally acclaimed prosthodontist and presenter Dr. Saj Jivraj ... , Dr. Jivraj, founder of a Ventura contemporary ... Institute, will speak about All-on-4™ dental implants ... Graft Less Solutions.” He is speaking at 12:40 p.m. ... & Conference Centre in Vancouver, British Columbia, Canada. , ...
(Date:9/19/2014)... Germany (PRWEB) September 19, 2014 ... that its new ND® Infusion Catheter is ... of Frankfurt. , The study commenced on September 4th, ... The use of the new catheter demonstrated a number ... known as stem cells. “We are at the forefront ...
(Date:9/19/2014)... Cancer researchers in Japan have identified ... where mesothelioma develops in the body. Click here ... important research. , Doctors with Nara Medical University ... mesothelioma (on the lung lining) and those with ... suggests that the pathway of the genetic abnormality might ...
(Date:9/19/2014)... September 19, 2014 In their ... find affordable home care options, Seniors Guide has ... on http://www.HomeCareChoice.com - their website ... in Virginia, North Carolina, Ohio, and Indiana. , ... licensing, costs, services offered, training and education, and ...
(Date:9/19/2014)... New York, NY (PRWEB) September 19, 2014 ... offers free Rx discounts on all commonly prescribed ... provider of free online drug coupons and has ... To further its mission of making prescription medications ... on all common high blood pressure medications. , ...
Breaking Medicine News(10 mins):Health News:Ventura Tooth Replacement and Restoration Expert to Speak at Vancouver Conference Tomorrow About All-on-4™ Procedure 2Health News:Ventura Tooth Replacement and Restoration Expert to Speak at Vancouver Conference Tomorrow About All-on-4™ Procedure 3Health News:Ventura Tooth Replacement and Restoration Expert to Speak at Vancouver Conference Tomorrow About All-on-4™ Procedure 4Health News:Ventura Tooth Replacement and Restoration Expert to Speak at Vancouver Conference Tomorrow About All-on-4™ Procedure 5Health News:First-in-man procedure utilizes a new method of stem cell delivery 2Health News:First-in-man procedure utilizes a new method of stem cell delivery 3Health News:New Study Finds Link Between Genes and Mesothelioma Location, Reports Surviving Mesothelioma 2Health News:Seniors Guide Offers Advice on How to Find the Right Home Health Care Agency 2Health News:HelpRx.info Now Providing Discounts on All Common High Blood Pressure Medications 2Health News:HelpRx.info Now Providing Discounts on All Common High Blood Pressure Medications 3
... Health has awarded $10.24 million to Fred Hutchinson Cancer ... to understand and prevent breast cancer disparities in Hispanic ... nationwide to receive funding as part of the NIH ... is launching a major new effort to understand and ...
... a specific type of dopamine receptor gene respond ... without the genotype, according to new research from ... come from the first-ever placebo-controlled pharmacogenetic drug trial ... to evaluate variants of the DRD4 dopamine receptor ...
... According ... the ages of 25 and 34 report being taught to practice defensive medicine. , ... Atlanta, GA (PRWEB) May 3, 2010 -- According to ... of physicians between the ages of 25 and 34 report being taught to practice defensive medicine., ...
... ... National Lupus Awareness Month 2010 with a 115-sq-ft display window at 10 Rockefeller Plaza to ... in the heart of New York City, was generously donated by EHE International for the ... (PRWEB) ...
... Mass. -- Our DNA is under constant siege from a ... of cells to repair that damage has broad health implications, ... used to study DNA damage are quite limited, but MIT ... analysis that promises to make an impact on human health. ...
... 3, 2010) The results of new research results ... of the American College of Surgeons show that ... a hospital surgical ward. Postoperative pneumonia is ... third most common infectious complication after urinary tract and ...
Cached Medicine News:Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 2Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 3Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 4Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 5Health News:Research helps end guesswork in prescribing ADHD drug 2Health News:Young Physicians Taught to Practice Defensive Medicine, Survey Finds 2Health News:Young Physicians Taught to Practice Defensive Medicine, Survey Finds 3Health News:Lupus Awareness Month Kicks Off at Rockefeller Center: EHE International Donates Display Window to S.L.E. Lupus Foundation for May 2Health News:Lupus Awareness Month Kicks Off at Rockefeller Center: EHE International Donates Display Window to S.L.E. Lupus Foundation for May 3Health News:Rapid analysis of DNA damage now possible 2Health News:Surgeons' pilot prevention program reduces incidence of postoperative pneumonia 2
(Date:9/19/2014)... September 19, 2014 Aufgrund ... den äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, der jetzt auch ... PDF, verfügbar unter pharmaserialisation.com , zeigt die ... jeweils in Kraft treten. Für international ... länger um das "ob", sondern darum, "wann" sie ...
(Date:9/19/2014)... , Sept. 19, 2014  Over 200 runners participated ... to Benefit the Radiation Oncology Institute (ROI), hosted by ... Golden Gate Park in San Francisco.  ... , CEO of Radiation Business Solutions, "but at ... raised over $70,000 for the ROI this year. This ...
(Date:9/19/2014)... Sept. 19, 2014 Intarcia Therapeutics, Inc. ... data for its lead candidate ITCA 650 (continuous subcutaneous ... high baseline HbA1c levels at the 50 th ... of Diabetes (EASD). Data from the open-label, phase 3 ... blood sugar in patients with poorly controlled type 2 ...
Breaking Medicine Technology:Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4
... Ill., April 7, 2011 MinuteClinic, the ... CVS ), has entered into a clinical affiliation ... enhance the high quality, affordable health care services provided ... It is the largest clinical collaboration between a regional ...
... A study published in the journal ... third-largest health system, has achieved remarkable results in eliminating ... and keeping patients safe.  In 2003, Ascension Health set ... Ascension Health has seen consistent improvement over the eight ...
Cached Medicine Technology:New Affiliation Between MinuteClinic and Advocate Health Care Increases Access to Medical Services in Chicagoland 2New Affiliation Between MinuteClinic and Advocate Health Care Increases Access to Medical Services in Chicagoland 3New Affiliation Between MinuteClinic and Advocate Health Care Increases Access to Medical Services in Chicagoland 4Study Highlights Successes of Ascension Health Quality Initiative 2
Anesthetists Precordial Kit incudes one set of 4 chromed plated chest pieces, a reusable monoscope of your choice, and 20 precordial adhesive discs....
Precordial Chestpieces are manufactured from chrome plated brass. Provides a hollow design with deep sound chambers for optimum acoustics....
Adhesive discs sold on rolls of 100, 250, or 1000 each. Manufactured from non-latex medical grade adhesives & material. One size fits all chest pieces....
For accurately monitoring heart and breath sounds....
Medicine Products: