Navigation Links
Protein protects against breast cancer recurrence in animal model
Date:6/13/2013

PHILADELPHIA - According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence the reappearance of the disease following treatment.

Precisely what causes breast cancer recurrence has been poorly understood. But now a piece of the puzzle has fallen into place: Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy. They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse.

The findings appear in this week's issue of Cancer Cell.

The study was led by Chodosh senior postdoctoral fellow, James V. Alvarez, PhD. Alvarez and his colleagues teased apart the role of Par-4 using a mouse model of recurrent breast cancer. In this model, turning "on" the HER2/neu oncogene in mice -- whi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... July 14, 2014 MED-Ed Facilities is ... our next conference, April 7+8 in Boston at the ... at the recent event. Presentations by individuals or teams ... To review the types of sessions that were presented ... Submit your proposal today! , Conference Director, The ...
(Date:7/13/2014)... 2014 MillionaireCasket.com is a professional supplier of ... wood caskets are selling well in the global market. Recently, ... caskets and launched a special offer for all the ... all the company’s cherry caskets are made with superb materials. ... for people to show respect to the departed saint. MillionaireCasket.com ...
(Date:7/13/2014)... York (PRWEB) July 13, 2014 Intraocular ... Trends and Forecast 2013 - 2019 , Intraocular lens ... suffering from myopia or cataracts. The lenses are inserted ... the cataract surgery intraocular lens replaces the focusing power ... with original crystalline lens to deliver the light focusing ...
(Date:7/13/2014)... July 13, 2014 Victorian Hotel has ... promoting the rental of bikes for its "Cycle the ... Victorian Hotel to tour the area using a rental ... Bicycle enthusiasts love to call Vancouver home, as it ... cycle travel and picturesque journeys through the countryside. Vancouver ...
(Date:7/13/2014)... 13, 2014 Fuel additives are chemicals, ... diesel, jet fuel, kerosene, and so on, in order ... for reducing the corrosion effects caused by fuels and ... to any fuel, provide economies of scale in the ... the overall cost of the fuel products. , The ...
Breaking Medicine News(10 mins):Health News:MED-Ed Facilities Conference Call for Speakers Open 2Health News:Brand New Cherry Caskets Unveiled By China Casket Supplier MillionaireCasket.com 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4
... 18, 2011) Scientists at the Children,s Center for ... of Children,s Hospital Los Angeles today announced a breakthrough ... They have identified a protein called CD19-ligand (CD19-L) located ... facilitates the recognition and destruction of leukemia cells by ...
... 18 (HealthDay News) -- A disease the affects your legs ... About 9 million Americans over the age of 50 ... risk for heart attack, according to the Vascular Disease Foundation ... have the condition, the foundation says. PAD occurs when ...
... Center for World Health & Medicine at Saint Louis University ... forming a global research partnership that initially will focus on ... connected by a shared commitment to fight a devastating disease, ... scientists who formerly worked together in Chesterfield, Mo. GIBH ...
... Wittig, M.D., chief of the division of skin and ... Hackensack University Medical Center will present eleven different educational ... upcoming American Academy of Orthopaedic Surgeons Conference. Dr. Wittig ... practices in limb-sparing surgery. In 2009, he and his ...
... rich plasma (PRP) to promote healing in various surgeries, ... PRP did not improve healing after rotator cuff repair. ... investigators, will be presented at the upcoming American Orthopedic ... held Feb. 19 in San Diego, Calif., following the ...
... Parents and caregivers have traditionally relied on cribs, playpens ... The massive crib recalls followed by the announcement in ... Commission (CPSC) to ban drop-side cribs have caused many ... new study conducted by researchers at the Center for ...
Cached Medicine News:Health News:Scientists bioengineer a protein to fight leukemia 2Health News:Leg Discomfort Might Signal Heart Trouble 2Health News:Saint Louis U scientists partner on malaria research 2Health News:John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques 2Health News:John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques 3Health News:John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques 4Health News:John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques 5Health News:John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques 6Health News:John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques 7Health News:Study shows PRP, commonly used technique to improve healing, doesn't work in rotator cuff surgery 2Health News:Study shows PRP, commonly used technique to improve healing, doesn't work in rotator cuff surgery 3Health News:New study finds 9,500 ED visits related to cribs, playpens and bassinets each year in US 2Health News:New study finds 9,500 ED visits related to cribs, playpens and bassinets each year in US 3
(Date:7/13/2014)... 2014  Eli Lilly and Company (NYSE: ... non-clinical study in genetically engineered mice examining combination ... antibody N3pG and beta-secretase inhibitor BACE (LY2811376). Data ... in removing clumps of amyloid-beta protein in the ... lead to Alzheimer,s disease (AD) – than use ...
(Date:7/11/2014)... , July 11, 2014  Rock Creek Pharmaceuticals, ... company, today announced that the Food and Drug Administration ... provide comments on RCP,s Investigational New Drug ("IND") application ... trial in the US. Dr. Chris ... review and comments on our IND. When we receive ...
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital ... to announce the opening of its new outpatient ... outpatient services to people with chronic, hard to ... which can lead to amputation, lower leg wounds ... have delayed closure, and traumatic injury wounds which ...
Breaking Medicine Technology:New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 2New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 3Rock Creek Pharmaceuticals Issues Update On US Investigational New Drug Application 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2
... in Akron (ABIA) and the U.S. Food and Drug ... support and develop regulatory science for the safe and ... Effective today, the FDA and ABIA executed a Memorandum ... upon ABIA resources—including a library of test methods for ...
... Fero Industries, Inc. (OTCQB: FROI), announced today ... has completed the registration process to become a ... institutions within Mexico. This license, which is the ... Company to provide coverage to PEMEX (Petroleos Mexicanos), ...
Cached Medicine Technology:FDA, Austen BioInnovation Institute to Collaborate on the Safety and Performance of Materials used in Medical Devices 2FDA, Austen BioInnovation Institute to Collaborate on the Safety and Performance of Materials used in Medical Devices 3Fero Industries, Inc. Achieves First Certified Supplier Status to Distribute Sucanon® in Mexico 2Fero Industries, Inc. Achieves First Certified Supplier Status to Distribute Sucanon® in Mexico 3
For Detection of Bile Component in Reflux Disease...
... With the advance of digital imaging ... advancing towards digital formats, allowing for ... This advance in digital pathology imaging ... occurred in radiology, and which is ...
... Analyzer II is a ... to enumerate fluorescently labeled ... selected and aligned. The ... CellTracks® Analyzer II, a ...
These Iron Control Slides make an excellent addition to your laboratory. Packed ten (10) control slides per box. Use SDL's Snap n' Stain for Iron Staining Kit alongside to save time an money mixing r...
Medicine Products: