Navigation Links
Protein predicts liver cancer recurrence and after transplantation
Date:2/3/2009

A new study suggests that Capn4, a protein involved in cell migration, is associated with liver cancer recurrence and metastasis after liver transplantation. Capn4 could potentially be used as a biomarker for diagnosis and a target for therapy. These findings are in the February issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Patients with liver cancer (also known as hepatocellular carcinoma) often undergo liver transplantation in an attempt to rid their bodies of the disease. Unfortunately, the cancer recurs in some patients and even metastasizes to other parts of the body, making their prognosis poor. It would be extremely useful to be able to identify patients at increased risk for recurrence. Proteomic technology could help, by identifying molecular markers that reveal a tumor's potential to spread.

Researchers, led by Jia Fan of the Liver Cancer Institute in Shanghai, utilized the technology to study liver cancer cells in search of proteins associated with recurrence of hepatocellular carcinoma after liver transplantation. They identified 149 proteins, including 52 that had changes in expression. Additional tests focused their interest on Capn4. They examined it further to determine its association with clinical outcomes of liver cancer patients who undergo transplantation.

The findings show that Capn4 is an important molecule associated with hepatocellular carcinoma metastasis and recurrence. "It was dramatically overexpressed in all metastatic tissues, while it was down-regulated in the non-metastatic tissues," they report.

They found that Capn4 expression was significantly correlated with tumor number, maximal tumor size, tumor encapsulation, venous invasion and pTNM stage. "Furthermore," they report, "patients with Capn4-positive tumors had an increasing risk of recurrence and significantly reduced overall post-transplant survival."

"This is the first study that describes the up-regulation of Capn4 associated with tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma," the authors write. They conclude that Capn4 has the potential to be used as a novel prognostic marker for liver cancer patients, and as a target for therapy.


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, ... ... in the patient payment industry today announced its strategic partnership with Connance, ... system workflows. , The two companies’ proven, proprietary technology combine to provide ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: