Navigation Links
Protein predicts liver cancer recurrence and after transplantation
Date:2/3/2009

A new study suggests that Capn4, a protein involved in cell migration, is associated with liver cancer recurrence and metastasis after liver transplantation. Capn4 could potentially be used as a biomarker for diagnosis and a target for therapy. These findings are in the February issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).

Patients with liver cancer (also known as hepatocellular carcinoma) often undergo liver transplantation in an attempt to rid their bodies of the disease. Unfortunately, the cancer recurs in some patients and even metastasizes to other parts of the body, making their prognosis poor. It would be extremely useful to be able to identify patients at increased risk for recurrence. Proteomic technology could help, by identifying molecular markers that reveal a tumor's potential to spread.

Researchers, led by Jia Fan of the Liver Cancer Institute in Shanghai, utilized the technology to study liver cancer cells in search of proteins associated with recurrence of hepatocellular carcinoma after liver transplantation. They identified 149 proteins, including 52 that had changes in expression. Additional tests focused their interest on Capn4. They examined it further to determine its association with clinical outcomes of liver cancer patients who undergo transplantation.

The findings show that Capn4 is an important molecule associated with hepatocellular carcinoma metastasis and recurrence. "It was dramatically overexpressed in all metastatic tissues, while it was down-regulated in the non-metastatic tissues," they report.

They found that Capn4 expression was significantly correlated with tumor number, maximal tumor size, tumor encapsulation, venous invasion and pTNM stage. "Further
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... A scar is an unavoidable result of incision or injury ... the body's ability to heal itself. The appearance of a scar is dependent on many ... genes, and skin pigmentation. ”Many scars fade to near invisibility on their own over a ...
(Date:9/3/2015)... ... 03, 2015 , ... “Love in Tokyo” an independent romantic comedy film by ... Amazon and will be released on DVD early next year, by Maverick Entertainment. ... an actress and singer/songwriter, and Jason London, lead from “Dazed and Confused.” , ...
(Date:9/3/2015)... ... September 03, 2015 , ... Representatives with State Farm Agent ... anticipated Mississippi Gulf Babypalooza on September 19, 2015. , “We will be providing ... and beyond. We will be discussing setting up college funds, offering information specific ...
(Date:9/3/2015)... WI (PRWEB) , ... September 03, 2015 , ... At ... after becoming dissatisfied with the traditional health care model, where the primary care physician ... of individuals who want to become educated about their health issues and empowered to ...
(Date:9/3/2015)... ... ... cases of prostate cancer are reported each year, along with 27,540 deaths attributed to the ... While only one man in 10,000 will typically get prostate cancer under age 40, the ... American Cancer Society. , Prostate cancer is the second leading cause of ...
Breaking Medicine News(10 mins):Health News:Do I Have To Live With That Scar? 2Health News:Do I Have To Live With That Scar? 3Health News:Do I Have To Live With That Scar? 4Health News:The Romantic Comedy Film "Love in Tokyo" Has Been Released on ITunes, Google Play, and Amazon 2Health News:State Farm Agent EJ Roberts to Help Expecting Mothers at the Mississippi Gulf Babypalooza 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 3Health News:Noted Santa Rosa Urologist Dr. Michael Lazar Provides Insights on Prostate Cancer Treatments in Recognition of Prostate Cancer Awareness Month 2Health News:Noted Santa Rosa Urologist Dr. Michael Lazar Provides Insights on Prostate Cancer Treatments in Recognition of Prostate Cancer Awareness Month 3
... ... Swingle, illustrates the use of neurotherapy in treating patients suffering from depression. Based in ... disorders, traumatic brain injury, depression, fibromyalgia, and autistic spectrum disorders, to name but a ... ...
... would eliminate guesswork, researchers say , FRIDAY, April 9 (HealthDay ... vaccines if the vaccines contained both strains of influenza B ... suggest. , "Adding a second influenza B virus strain to ... out of strain selection and help improve the vaccine,s ability ...
... the developing world has grown dramatically over the last two ... Health Metrics and Evaluation (IHME) at the University of Washington ... on health doubled in low-income countries over 12 years to ... three times as much as the amount of development assistance ...
... Created by ... now available to the public. Made of solid stainless steel, this mouse pad is a ... ... only solid stainless steel mouse pad, the "DXTRA Series 1000". This mouse pad is hand ...
... and treatment, expert says , FRIDAY, April 9 (HealthDay ... smokers who have a medical condition that puts them ... Researchers from Caen University Hospital in France found that ... agitated and accidentally remove tubes and catheters, require additional ...
... ... the Clothesline Project to raise awareness of violence and abuse , ... Washington, D.C. (Vocus) April 9, 2010 -- Children,s National ... and exhibition, featuring T-shirt artwork designed by youth who have been affected by violence or ...
Cached Medicine News:Health News:Psychologist and Author Paul G. Swingle Talks about his Approach to Treating Depression and Mood Disorders in Online Forum 2Health News:Psychologist and Author Paul G. Swingle Talks about his Approach to Treating Depression and Mood Disorders in Online Forum 3Health News:Flu Vaccine With Both B Strains May Offer Better Protection 2Health News:Developing countries devote more funding to health, except many in sub-Saharan Africa 2Health News:Developing countries devote more funding to health, except many in sub-Saharan Africa 3Health News:Nicotine Withdrawal Can Complicate Hospital Care 2Health News:Children's National Hosts Fourth Annual Youth Anti-Violence Exhibition 2Health News:Children's National Hosts Fourth Annual Youth Anti-Violence Exhibition 3
(Date:9/2/2015)... NEW YORK , Sept. 2, 2015 /PRNewswire/ ... equipment market studies the current and future prospects ... monitoring of patient,s health and assists medical practitioners ... track the disease progression during treatment. Multi-parameter patient ... care and chronic disease. Geriatric population is observed ...
(Date:9/2/2015)... , Sept. 2, 2015 About Duchenne ... X-linked disease, which generally affects the male population. ... weakness. The disease is caused due to mutations ... lack of production of dystrophin (a protein essential ... lack of dystrophin weakens muscle function, causes loss ...
(Date:9/2/2015)... Sept. 2, 2015 Transaction ... base with highly profitable specialty products , ... growth potential with 11 product applications pending at ... certifications  , Provides medium and longer term ... including eight controlled substances , Adds development ...
Breaking Medicine Technology:Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 2Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 3Global Duchenne Muscular Dystrophy Drugs Market 2015-2019 2Global Duchenne Muscular Dystrophy Drugs Market 2015-2019 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 2Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 4Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 5Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 6
... Medical, Inc.®, a leading innovator and developer of ... it has received Investigational Device Exemption (IDE) approval ... ("FDA") to begin a prospective, multicenter, randomized clinical ... Surgical Adhesive in the United States. ...
... SAUSALITO, Calif., Jan. 24, 2012   Sanovas , ... diagnosing and treating cancer and chronic diseases, announced ... and opened a manufacturing site in Sausalito, Calif. ... Sanovas, technology ahead of filing for U.S. Food ...
Cached Medicine Technology:Cohera Medical Receives IDE Approval to Begin Pivotal Clinical Trial for TissuGlu® Surgical Adhesive in the U.S. 2Sanovas Expands Headquarters and Opens Manufacturing Site 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: