Navigation Links
Protein plays a critical role in the development of aggressive breast cancer
Date:4/20/2010

WASHINGTON, D.C. (April 20, 2010)Researchers at Fox Chase Cancer Center have identified a potentially significant molecular player in the development of aggressive breast cancer. The team's findings show that a protein called NEDD9 is critical in the formation of breast tumors induced by high levels of the cell-surface receptor HER2/neu in mice. HER2-driven breast cancer is known to be one the most aggressive forms of the disease.

Joy L. Little, Ph.D., a postdoctoral fellow in the laboratory of Erica A. Golemis, Ph.D., at Fox Chase Cancer Center, will present the findings at the 2010 annual meeting of the American Association for Cancer Research.

In mice engineered to overexpress the HER2/neu gene, Little and her colleagues found that 89% of mice with the Nedd9 gene developed tumors over an 18-month period. In comparison, only 29% of mice without the Nedd9 gene developed tumors. These findings indicate a novel role for NEDD9 in tumor initiation.

"There is a lot of research describing contributors to cancer formation, but it is always truly exciting when studies show that the loss or absence of something prevents cancer from occurring," says Little. "The fact that in the majority of our animals, HER2-driven tumors don't form without NEDD9 is new information we can use to view NEDD9 as a potential biomarker. If tumors show higher levels of NEDD9, it could be they are more aggressive."

Based on the data collected, researchers are now poised to delve deeper into discovering what about the biology of NEDD9 makes it crucial in the formation stages of HER2-driven tumors. Pharmacological targeting of NEDD9 could also be therapeutically relevant, Little notes.


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Structure of inner-ear protein is key to both hearing and inherited deafness
2. Temperature-sensing protein linked to skin cancer, hirsutism
3. Protein May Help Control Weight
4. The assembly of protein strands into fibrils
5. Leukemia-related protein 16 and colorectal carcinoma
6. Caltech scientists uncover structure of key protein in common HIV subgroup
7. UD team develops new method for producing proteins critical to medical research
8. Proteins in unroasted coffee beans may become next-generation insecticides
9. Protein in Breast Tumors May Predict Chemo Response
10. Tumors Use a Protein to Hide From Immune System
11. Newly identified proteins critical to FA pathway DNA repair function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... 2017 , ... 38-Year-Old Plastic Surgeon Gill at Aesthetic Surgery Center is Saluted ... announce that Plastic Surgeon Kiranjeet Gill has been awarded as one of the 15th ... award that was started in 2003 to salute young achievers in Southwest Florida who ...
(Date:9/21/2017)... Falls Church, VA (PRWEB) , ... September 21, ... ... **An FDAnews Webinar**, Sept. 26, 2017 — 1:30 p.m. – 3:00 p.m. ET, ... exacting business. It’s easy to get things wrong, run afoul of The Quality ...
(Date:9/21/2017)... IL (PRWEB) , ... September 21, 2017 , ... SABRE ... to run from September 11 to the end of November. , The Chicago, Illinois, ... to their community and teach them about the ease of taking their personal safety ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... with Infinity Behavioral Health Services for professionals in the addiction treatment industry entitled: ... Audit . , Insurance companies and state and federal governments are increasingly ...
(Date:9/21/2017)... , ... September 21, 2017 , ... ... FDAnews Management Report**, http://www.fdanews.com/products/54818-promotional-communication      , In the competitive world of drug ... get while staying in compliance with FDA rules. , The FDA has issued ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound ... ... Jim Bertolina, PhD ... Tom Tefft ... device executive Josh Stopek , PhD, who has led R&D and business development teams ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
Breaking Medicine Technology: