Navigation Links
Protein paves the way for correct stem cell differentiation
Date:2/7/2013

Timing of gene activity is not only crucial during development, but has to be maintained throughout the lifespan of any cell. Some genes are active at a certain times, but inactive at other times.. Here PRC1 comes into play. PRC1 is dynamically recruited to and dissociated from genes according to the needs of our organism. When cancer strikes, this tight regulation of gene activity is often lost and the cells are locked in a less differentiated stage. This loss of differentiation and the accumulation of other mutations allow the cancer cells to undergo indefinite self-renewal through endless cell divisions, an ability that normal differentiated cells are prohibited from through tight gene regulation.

"Given the emerging relationship between cancer and stem cells, our findings may implicate that an aberrant activity of Fbxl10 can disturb PRC function and promote a lack of differentiation in our cells. This makes it worth studying whether blocking the function of Fbxl10 could be a strategy for tumour therapy", says Xudong Wu.

And that is exactly what the researchers want to try. In collaboration with the biotech company EpiTherapeutics, the researchers want to develop inhibitors to Fbxl10 as a potential novel therapy for cancer.

The results are published in the journal Molecular Cell on February 7, 2013: Wu et al.: Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation.


'/>"/>

Contact: Katrine Sonne-Hansen
katrine.sonne@bric.ku.dk
(45) 35-32-56-48
University of Copenhagen
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Excess protein linked to development of Parkinsons disease
2. Muscular Development Store Comments on Efficacy of Protein Blends
3. Scientists discover protein that allows safe recycling of iron from old red blood cells
4. The Muscular Development Store Comments on How Optimum Nutrition’s Protein Supplements Fit Into Your Workout
5. DNA-repairing protein may be key to preventing recurrence of some cancers
6. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
7. UT MD Anderson scientists find protein that reins in runaway network
8. Lack of protein Sp2 disrupts neuron creation in brain
9. Protein identified that can disrupt embryonic brain development and neuron migration
10. Dr. Harvey’s Launches "Oracle": a Revolutionary Freeze-Dried, Highly Nutritious and Protein-Rich Line of Complete Foods for Dogs and Cats
11. Protein recognition and disorder: A debate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein paves the way for correct stem cell differentiation
(Date:7/24/2014)... (PRWEB) July 24, 2014 Ticket Down ... Roma Tickets in Denver at the Sports Authority Field on ... (or World Football Challenge) has brought some of the best club ... With the World Cup still being raved about weeks after its ... chance to see some of the biggest stars in the world ...
(Date:7/24/2014)... The report, “Content Delivery Networks (CDN) ... various sub-segments with an in-depth analysis and forecasting ... restraints for this market with insights on trends, ... tables and 36 figures spread through 157 pages ... Market” at http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . , Early ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 The ... http://www.injurybeacon.com/granuflo-dialysis/lawsuit/ ) in the U.S. District Court, ... order for plaintiff medical information covered by the ... to the July 16th Order, U.S. District Judge ... for Fresenius Medical Care the right to receive ...
(Date:7/24/2014)... In a July 9th article in the Money ... Lotus Blossom Consulting LLC , was quoted in a Family ... Cut the High Cost of Infertility . Her advice began ... maximize your chance of success from the first attempt.” The ... “I am always happy to talk with the media ...
(Date:7/24/2014)... announced its 2014 Power of A Award winners, including ... (ASA). , The ASA Global Humanitarian Outreach (GHO) ... of the top honors from ASAE. GHO was honored ... education on the global anesthesia crisis and supporting low ... also honored with a Power of A Silver Award ...
Breaking Medicine News(10 mins):Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3
... Mich. Women are under-represented in clinical cancer research ... by researchers at the University of Michigan Comprehensive Cancer ... types of cancer among women, studies included a smaller ... looked specifically at studies of cancer types that were ...
... New York Blood Center (NYBC) and its divisions in Manhattan, Long ... big challenges this season to maintain an adequate and safe blood ... One: Concerns About H1N1 (Swine Flu) ... were temporarily closed. The canceled drives have meant the loss ...
... do as well as surgery, especially in less severe cases ... the first line of treatment for diabetics who are also ... further steps are deemed necessary should invasive interventions such as ... The issue is crucial to millions of Americans, since diabetes ...
... Harkin to Host Event With ... , WASHINGTON, June 7 Barbara Manard, ... Homes and Services for the Aging (AAHSA), will join an esteemed ... briefing on current HELP efforts to include long-term services and support ...
... HOUSTON, June 6 The City of Houston and its ... Group,s 3rd Annual Houston Juneteenth Multicultural Health Festival (HJMHF) on ... Festival moves indoors to the George R. Brown Convention Center, ... than 180,000 square feet of air-conditioned exhibit space, this year,s ...
... tips to minimize golf-related injuries , SATURDAY, June 6 ... the body than many other sports, but don,t be fooled. ... of the bones, muscles or joints, warns the American Academy ... professionals treated more than 103,000 golf-related injuries in 2007. ...
Cached Medicine News:Health News:Women under-represented in cancer research, U-M study finds 2Health News:Our Communities' Blood Supply Faces Summer Challenges 2Health News:Our Communities' Blood Supply Faces Summer Challenges 3Health News:Drugs Best First Defense Against Heart Disease for Diabetics 2Health News:Drugs Best First Defense Against Heart Disease for Diabetics 3Health News:2009 Houston Juneteenth Multicultural Health Festival Becomes Largest Health Event in Texas: Festival Moves Indoors to the Cool George R. Brown 2Health News:Good Golf Form Can Improve Game and Prevent Pain 2
(Date:7/24/2014)... July 24, 2014 Many new dentists who are ... to ensure that their practice will be a success. DentalDisposables.net ... supplies they use the most can make all the difference. ... have recently discovered that purchasing discount dental supplies ... According to successful dentists across the United ...
(Date:7/24/2014)... July 24, 2014 Talyst, a market leader ... National Association of State Veterans Homes (NASVH) Summer Conference ... goal of the NASVH is to ensure that each ... long term health care and respect which they have ... With the InSite® Remote Dispensing System, Talyst can help ...
(Date:7/24/2014)... BURLINGTON, Mass. , July 24, 2014 ... asthma, pulmonologists in the EU5 countries ( France ... Italy , Spain and ... generally positive view of the first once-daily long-acting beta2 ... pulmonologists expect robust uptake of Relvar as a first-line ...
Breaking Medicine Technology:Dental Supplies Online is Key to Dental Success...Really! 2Talyst Exhibits at the National Association of State Veterans Homes Summer Conference 2Surveyed EU5 Pulmonologists Expect that Relvar, the First Once-Daily LABA/ICS FDC, Will Experience Healthy Uptake in Asthma 2Surveyed EU5 Pulmonologists Expect that Relvar, the First Once-Daily LABA/ICS FDC, Will Experience Healthy Uptake in Asthma 3
... Oct. 11 More than 170 industry experts and ... four executive workshops at AdvaMed 2010: The MedTech ... its fourth year, this annual medical technology industry developed ... U.S. and around the world.   "This ...
... Holdings Corp. (Nasdaq: TLCR ) will issue its ... October 28, 2010. Due to the pending merger with Grifols, ... discuss its third quarter results. About Talecris ... Talecris Biotherapeutics is a global biotherapeutic and biotechnology company ...
Cached Medicine Technology:Medical Technology, Funding & Government Experts Address Business, Investment, Reimbursement, Compliance, Innovation, Regulatory and Legal Issues at AdvaMed 2010 2Medical Technology, Funding & Government Experts Address Business, Investment, Reimbursement, Compliance, Innovation, Regulatory and Legal Issues at AdvaMed 2010 3
... mini-cells has always distinguished itself by ... tradition continues with the patented XCell ... gel tension wedge in place of ... models makes the XCell SureLock and ...
... Multidizer is designed with a variety of ... - all in one unit. Shake, rock, ... operating compartments allow for hybridization and blotting ... , The upper chamber uses a ...
... unit ideal for use in laboratories with low ... set at 12 rpm , Temperature control ... capacity of four 35 x 150mm bottles, eight ... , Consistent, repeatable results achieved with microprocessor ...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Medicine Products: