Navigation Links
Protein paves the way for correct stem cell differentiation
Date:2/7/2013

Timing of gene activity is not only crucial during development, but has to be maintained throughout the lifespan of any cell. Some genes are active at a certain times, but inactive at other times.. Here PRC1 comes into play. PRC1 is dynamically recruited to and dissociated from genes according to the needs of our organism. When cancer strikes, this tight regulation of gene activity is often lost and the cells are locked in a less differentiated stage. This loss of differentiation and the accumulation of other mutations allow the cancer cells to undergo indefinite self-renewal through endless cell divisions, an ability that normal differentiated cells are prohibited from through tight gene regulation.

"Given the emerging relationship between cancer and stem cells, our findings may implicate that an aberrant activity of Fbxl10 can disturb PRC function and promote a lack of differentiation in our cells. This makes it worth studying whether blocking the function of Fbxl10 could be a strategy for tumour therapy", says Xudong Wu.

And that is exactly what the researchers want to try. In collaboration with the biotech company EpiTherapeutics, the researchers want to develop inhibitors to Fbxl10 as a potential novel therapy for cancer.

The results are published in the journal Molecular Cell on February 7, 2013: Wu et al.: Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation.


'/>"/>

Contact: Katrine Sonne-Hansen
katrine.sonne@bric.ku.dk
(45) 35-32-56-48
University of Copenhagen
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Excess protein linked to development of Parkinsons disease
2. Muscular Development Store Comments on Efficacy of Protein Blends
3. Scientists discover protein that allows safe recycling of iron from old red blood cells
4. The Muscular Development Store Comments on How Optimum Nutrition’s Protein Supplements Fit Into Your Workout
5. DNA-repairing protein may be key to preventing recurrence of some cancers
6. A blend of soy and dairy proteins promotes muscle protein synthesis when consumed after exercise
7. UT MD Anderson scientists find protein that reins in runaway network
8. Lack of protein Sp2 disrupts neuron creation in brain
9. Protein identified that can disrupt embryonic brain development and neuron migration
10. Dr. Harvey’s Launches "Oracle": a Revolutionary Freeze-Dried, Highly Nutritious and Protein-Rich Line of Complete Foods for Dogs and Cats
11. Protein recognition and disorder: A debate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein paves the way for correct stem cell differentiation
(Date:8/27/2014)... Spring, Md. (PRWEB) August 27, 2014 ... (CHEST) recently released guidelines for the management and ... Pharmacological Therapy for Pulmonary Arterial Hypertension in Adults: ... are free to view for clinicians, and provide ... PAH. , The Pulmonary Hypertension Association ...
(Date:8/27/2014)... Neward, NJ (PRWEB) August 27, 2014 ... top-10 finish at The Ridgewood County Club during The ... leader board in each of the tournament’s four rounds, ... through the Horizon Blue Cross Blue Shield of New ... BCBSNJ challenged Hoffmann, a Wyckoff native playing before family ...
(Date:8/27/2014)... hormone therapy has spawned a prevalent but preventable side ... flashes, according to a study by a Yale School ... study published in the Aug. 27 online issue of ... moderate to severe hot flashes also called vasomotor ... Women with VMS experience more than feeling hot; other ...
(Date:8/27/2014)... 2014 (HealthDay News) -- Young adults who struggled with ... their brain, researchers are reporting. The findings might ... ways to predict, prevent and treat the illness, according ... The researchers conducted brain scans on 30 volunteers, ages ... years, and a control group of 23 young adults ...
(Date:8/27/2014)... Ticket Down is a dependable source for ... in Santa Clara. Levi’s Stadium is a brand new ... July and will host their first international soccer match on ... two of the best teams that are both coming off ... to continue their successes from the tournament in this international ...
Breaking Medicine News(10 mins):Health News:Pulmonary Hypertension Association Endorses CHEST Guidelines for Treatment of Pulmonary Arterial Hypertension in Adults 2Health News:Morgan Hoffmann, PGA TOUR Pro & Wyckoff Native, golfs and walks his way to top 10 finish at The Barclays while raising additional $7,500 for charity 2Health News:The high cost of hot flashes: Millions in lost wages preventable 2Health News:Study: Young Adults Who Had Depression Have 'Hyper-Connected' Brain Networks 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3
... Volunteers Trained Across the US and Canada DULUTH, ... welfare of animals and raising public awareness about rabies, ... international, nonprofit pet disaster relief organization, to provide rabies ... of this effort, Merial technical service veterinarians are traveling ...
... to the Field of Health Care Public Relations, Through ... Society of America (PRSA) and Ketchum ... PRSA Health Academy,s Frank J. Weaver Lifetime Achievement Award ... work and leadership in health care public relations.The award ...
... Veterinary Care Digital Imaging and Data Management Providers ... Eklin Medical Systems, a leading provider of ... Communications Systems) and practice management software (VIA(R)) for ... Thorn as the company,s West Coast ultrasound representative. ...
... the food poisoning bug Salmonella feeds on to ... of Salmonella ,s weakness for sugar could provide a ... lead to vaccine strains to protect against other disease-causing bacteria, ... anyone has identified the nutrients that sustain Salmonella ...
... contaminating food supplies and are a huge commercial pest, but ... role in the management of endangered species. , The flour ... the model in a major new study into the consequences ... this summer. , Inbreeding is a potentially important problem in ...
... to Enable System Turn-On At Grand Opening and ... LodgeNet Healthcare, a division of LodgeNet Interactive ... leading provider of interactive patient television solutions, today ... is now serving patients at the Oklahoma Heart ...
Cached Medicine News:Health News:Taking a Bite Out of Rabies: Merial Provides Rabies Awareness and Prevention Training to Noah's Wish Pet Disaster Relief Organization 2Health News:Taking a Bite Out of Rabies: Merial Provides Rabies Awareness and Prevention Training to Noah's Wish Pet Disaster Relief Organization 3Health News:Ketchum's Nancy Hicks Honored with PRSA Health Academy's Lifetime Achievement Award 2Health News:Ketchum's Nancy Hicks Honored with PRSA Health Academy's Lifetime Achievement Award 3Health News:Ketchum's Nancy Hicks Honored with PRSA Health Academy's Lifetime Achievement Award 4Health News:Eklin Medical Systems Appoints Juan Thorn as West Coast Ultrasound Sales Representative 2Health News:Salmonella's sweet tooth predicts its downfall 2Health News:Beetles drive groundbreaking conservation project 2Health News:LodgeNet Healthcare Announces Deployment of Interactive Patient Television System in Oklahoma Heart Hospital 2Health News:LodgeNet Healthcare Announces Deployment of Interactive Patient Television System in Oklahoma Heart Hospital 3
(Date:8/27/2014)... -- ISPE , the International Society for Pharmaceutical ... of its Drug Shortages Prevention Plan aimed ... maintain a robust and reliable supply of medications to ... for the industry, was developed by ISPE and its ... industry can best prevent drug shortages from occurring by ...
(Date:8/27/2014)... , Aug. 27, 2014  Hill-Rom Holdings, Inc. ... to a management presentation at the Morgan Stanley Global ... EDT. You are invited to listen to ... http://ir.hill-rom.com/events.cfm or access it directly at http://cc.talkpoint.com/morg007/090814a_ac/?entity=26_7CLOGQP ... available one hour after conclusion of the live event ...
(Date:8/27/2014)... Sihuan Pharmaceutical Holdings Group Ltd. (HKEx: ... pharmaceutical company with the largest cardio-cerebral vascular ("CCV") ... prescription drug market, today announced the unaudited consolidated ... the "Group") for the six months ended 30 ... the Six months ended 30 JuneKey Income Statement ...
Breaking Medicine Technology:ISPE Releases First Look at its Plan to Prevent Drug Shortages 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 3ISPE Releases First Look at its Plan to Prevent Drug Shortages 4Sihuan Pharmaceutical Announces 2014 Interim Results 2Sihuan Pharmaceutical Announces 2014 Interim Results 3Sihuan Pharmaceutical Announces 2014 Interim Results 4Sihuan Pharmaceutical Announces 2014 Interim Results 5Sihuan Pharmaceutical Announces 2014 Interim Results 6Sihuan Pharmaceutical Announces 2014 Interim Results 7
... NEW YORK, Feb. 22, 2011 Reportlinker.com announces ... in its catalogue: Global Pharmaceutical ... This report analyzes the worldwide ... by the following Dosage Forms: Injectables (Injections, Vials, ...
... 22, 2011 Delcath Systems, Inc. (Nasdaq: ... a "refusal to file" letter from the U.S. Food ... (NDA) for its proprietary chemosaturation system used in the ... through the percutaneous intra-arterial administration of melphalan hydrochloride.  Delcath ...
Cached Medicine Technology:Reportlinker Adds Global Pharmaceutical Contract Manufacturing Industry 2Delcath Systems Receives Refusal to File Letter From FDA 2Delcath Systems Receives Refusal to File Letter From FDA 3Delcath Systems Receives Refusal to File Letter From FDA 4
MT-BT-5011-25 Prostate seeding needle (set of 25 unloaded needles).,MT-BT-5011-P Prostate seeding needle, pre-plugged and pre-sterilized, unloaded or for use with MEDTECs ASAP™ pre-load seedin...
... classes of resectoscope electrodes for urological ... roller bar & ball, and coagulating. ... specifically integrated into the ACMI resectoscope. ... minimal bleeding, increased visibility, and decreased ...
... and MRO™-2005 Rigid Percutaneous Nephroscopes combine ... throughput capacity with proven MRO performance. ... with small size sheaths. The MRO™-20 ... easy positioning during percutaneous procedures. The ...
... Olympus SurgMaster OES Pro Resectoscope is based ... standard resectoscope and enables the surgeon to ... by exchanging the working element, HF cable ... be upgraded for resection in saline, supporting ...
Medicine Products: