Navigation Links
Protein offers new clue to cause and treatment for kidney disease
Date:12/12/2010

docytes, the researchers were able to increase the amount of protein-bound sialic acid, and reduce the amount of protein leakage into the urine by more than 40 percent.

"These findings, at present, most directly relate to minimal change disease, a form of nephrotic syndrome commonly seen in children, but are also likely to be relevant to common causes of proteinuria and nephrotic syndrome in adults, including those with diabetes," Chugh said.

He added that this study is important because traditional forms of therapy, which include the use of glucocorticoids, for example prednisone, and other immunosuppressive drugs can have significant toxicity, especially after prolonged use or repeated cycles of treatment. However, sialic acid and ManNAc are naturally occurring substances in the body, and toxicity is likely to be limited. The investigators, he said, believe that relatively small doses of the sialic acid may be effective for nephrotic syndrome, since, unlike most other cells in the body, the target cell in the kidney does not divide under most conditions and is likely to accumulate these compounds even at low doses.

"The major known toxicity of sialic acid therapy observed by other investigators in a mouse model of the human muscle disease, hereditary inclusion body myopathy, was the development of ovarian cysts at very high doses," Chugh said. "These doses are approximately 20-fold higher than those used to reduce proteinuria in rats in the current study; knowing that, we believe sialic acid repletion has potential in the future treatment of Minimal Change Disease and some other forms of nephrotic syndrome."


'/>"/>

Contact: Jennifer Park Lollar
jpark@uab.edu
205-934-3888
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Top10BestSEOHosting.com is a well-known review ... that HostGator.com http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts is the best ... they has announced that Bluehost and Arvixe are ... one of the Top 10 Web Hosting in ... hosting, and it offers rich features and great ...
(Date:8/30/2014)... York (PRWEB) August 30, 2014 August ... and shoulder pain in our society and the toll ... production costs, it’s vital that continuing education for physical ... goal to help physical therapists help others, Hands-On Seminars ... 2nd. , Three learning styles are available ...
(Date:8/30/2014)... August 30, 2014 Jake W., 18, is ... in the Back2Basics Outdoor Adventures transition program known ... high school so I can actually start on a real ... math, and I'm done.” , He has six months of ... program. Most clients choose to continue on to the Beyond ...
(Date:8/30/2014)... 30, 2014 “In 2013, a vehicle crash ... Firm says in a recently released article on 2013 ... injured in an auto accident every 12 minutes, and a ... continue. “Based on the 2013 statistics, between now and this ... , The threat of an auto accident is real and ...
(Date:8/30/2014)... FL (PRWEB) August 30, 2014 Zensah®, the ... Camo Compression Leg Sleeve . The camo sleeves are ... Leg Sleeve collection. The camo line includes classic colors ... and magenta. , Known as tibial stress syndrome, shin ... of the lower leg. Swollen and irritated muscles, stress fractures, ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2Health News:Leader in Manual Therapy Continuing Education Makes it Easier for Physical Therapists to Improve Results on Patients 2Health News:Startling Washington Auto Accident Statistics Discussed In Recently Released Article By The Jones Firm 2Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2
... are pulling back on cosmetic procedures during the recession, the ... laser vein removal . Unfortunately, most people who need ... that beautiful, healthy legs are within their budget since most ... varicose veins removed promptly, individuals are at risk ...
... to PerformLOS ANGELES, May 28 The Pediatric Inflammatory ... honor Producer Alexandra Milchan-Lambert and Relativity Media President of ... 14, 2009 at Culver Studios. The afternoon will ... families and will feature a fun-filled day of activities ...
... LTC EconomiesWASHINGTON, May 28 CoCares, a ... voice and advocate in Washington, DC for community businesses ... by providing vital services directly and tangentially related to ... opposition to any loss of federal funding that could ...
... into Sexually-Transmitted Diseases and AIDS in Catalonia (CEEISCAT) started ... into the prevalence of sexually-transmitted diseases (STDs) among female ... rates of infection with both HIV and other diseases ... behaviour. , "The phenomenon of prostitution has changed ...
... 28 The Florida Association for Healthcare Quality (FAHQ) ... to the Conference theme, It,s All About the Patient, ... by including presentations by two Patient Advocates, both of ... These presentations served to open and close the conference, ...
... data pool is publishing supplier data to the ... available to providers and other data subscribers; market ... Colo., May 28 /PRNewswire/ -- ... ConneXion(TM) data pool, a healthcare-focused data pool certified ...
Cached Medicine News:Health News:Get Sexy Summer Legs From Renaissance Laser and Vein Institute (laserandveinclinic.com) Courtesy of Your Health Insurance 2Health News:The Pediatric IBD Center at Cedars-Sinai Medical Center Presents Rock-n-Reel 2009 Honoring Alexandra Milchan-Lambert & Scott Lambert 2Health News:Community Businesses Impacted by Looming Cuts to Long Term Care Federal Funding 2Health News:Community Businesses Impacted by Looming Cuts to Long Term Care Federal Funding 3Health News:Community Businesses Impacted by Looming Cuts to Long Term Care Federal Funding 4Health News:Spanish prostitutes least likely to use condoms 2Health News:Patient Advocates Educate Healthcare Quality Leaders 2Health News:GHX Launches the Health ConneXion(TM) GDSN-Certified Data Pool to Accelerate Use of GS1 Standards in Healthcare 2Health News:GHX Launches the Health ConneXion(TM) GDSN-Certified Data Pool to Accelerate Use of GS1 Standards in Healthcare 3
(Date:8/29/2014)... 2014  BC Technical, the nation,s leading non-OEM provider ... a leader in sales, service and installation of GE ... Technical to continue to expand their resources and inventory ... modalities. "We are committed to driving ... , president and CEO of BC Technical. "We set ...
(Date:8/29/2014)... 2014 Research and Markets  has announced the ... 2014" report to their offering. The ... of the largest segments of pharmaceuticals industry. The numbers of ... available therapies were unable to meet the market requirements. There ... CNS disorder, especially over the past two decades. The market ...
(Date:8/29/2014)... -- Research and Markets has announced the ... of Pharmaceutical Equipment Market in China, 2014-2018" report ... Trend Forecast of Pharmaceutical Equipment Market in ... pharmaceutical equipment industry in the aspects of ... business performance of domestic major enterprises, as well as ...
Breaking Medicine Technology:BC Technical Acquires Polaris Medical Imaging 2US CNS Disorders Drug Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
... PRINCETON, N.J., Jan. 10, 2011 CoreLab Partners, ... between RadPharm, Inc and Medifacts International, has launched a ... "We are pleased to announce the release of ... the drug development continuum by offering sponsors advanced technologies ...
... Jan 10, 2011 /PRNewswire-Asia-FirstCall/ -- Mindray Medical International Limited ... and marketer of medical devices worldwide, today announced updates ... pipeline for domestic and international markets in 2011. ... of ten products, meeting new product development goals outlined ...
Cached Medicine Technology:CoreLab Partners Launches Advanced Imaging Application 2CoreLab Partners Launches Advanced Imaging Application 3Mindray Medical Meets 2010 Product Development Targets and Announces Strong 2011 Pipeline 2Mindray Medical Meets 2010 Product Development Targets and Announces Strong 2011 Pipeline 3Mindray Medical Meets 2010 Product Development Targets and Announces Strong 2011 Pipeline 4