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Protein made by fat cells may increase risk of heart attack in older adults
Date:7/30/2008

. He said that further studies are needed to understand why adiponectin has such beneficial effects on cholesterol profile and diabetes, but apparently different associations with cardiovascular disease in older adults as compared with middle-aged adults.

Dr. Kizer and others theorize that higher adiponectin concentration may reflect underlying disease processes in the body, or even have direct harmful effects, which may be amplified in the elderly. Adiponectin has been shown to increase energy expenditure through direct actions in the central nervous system in mice, and if this effect were also present in humans, it could be significantly harmful in older adults by accelerating the loss of skeletal muscle, a condition called sarcopenia.

"This study shows that this abundant product of fat cells is a marker and perhaps even a mediator of worsened outcomes in persons aged 65 years and older," said Dr. Kizer. "Further studies should target this protein to unravel the mechanisms responsible."


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Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

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