Navigation Links
Protein linked to therapy resistance in breast cancer
Date:9/11/2012

development of many types of cancer.

"We hypothesized that resistance to EGFR-TKIs originated, at least in part, from molecular alterations that activated phosphorylation signaling downstream of EGFRs," Furuta says.

Using a unique three-dimensional cell culture assay based on phenotypic reversion that was originally developed by Bissell and her research group, the co-authors of the JCI paper screened for genes involved in EGFR-TKI resistance in both normal and cancerous human breast cell lines. They found that, while normal human breast tissue doesn't produce FAM38A, the protein is highly expressed in cancerous tissue. This was true for every breast cancer cell line they examined, and was particularly pronounced in those cell lines that have been the most resistant to treatment with EGFR-TKIs. Further studies showed that FAM83A interacts with and causes phosphorylation of critical signaling proteins downstream of EGFRs, as the researchers hypothesized. This downstream phosphorylation would act to blunt or negate any therapeutic effects of EGFR-TKIs that took place further upstream.

The results of this research are consistent with clinical data showing that breast cancer patients with high levels of FAM83A have a significantly lower survival rate than patients with low levels of FAM83A. However, while Bissell, Furuta and their colleagues note that a number of questions about FAM83A and other members of the FAM83 protein family remain to be addressed, the importance of these proteins as potential drug targets for therapy seems clear.

"The beauty of this study is that it not only helps explain why some breast cancer patients are resistant to EGFR-TKIs, but it also reveals a whole new family of potential oncogenes that could be a target for all types of cancer, including breast cancer," Bissell says.

Bissell says the results of this study also demonstrate the potential of using 3D phenotypic reversion assays as a new path
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Well-known protein reveals new tricks
2. Binding sites for LIN28 protein found in thousands of human genes
3. Immune system protein could explain pancreatitis
4. In Diabetes, Any Protein in Urine May Signal Heart Risk
5. Protein impedes microcirculation of malaria-infected red blood cells
6. Protein found to regulate red blood cell size and number
7. Toward medicines that recruit the bodys natural disease-fighting proteins
8. New laboratory test assesses how DNA damage affects protein synthesis
9. Stem cells can become anything - but not without this protein
10. Alzheimer protein seems to slow down neurotransmitter production
11. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein linked to therapy resistance in breast cancer
(Date:12/24/2014)... Risperdal lawsuit ( http://www.risperdallawsuit2014.com/ ) ... currently underway in Pennsylvania’s Philadelphia Court of Common Pleas, ... 2014, court documents indicate that 1,183 claims had been ... developed gynecomastia (male breast growth) and other complications allegedly ... that this represents an increase of more than 100 ...
(Date:12/24/2014)... Dr. Vu Ho, a Dallas based facial plastic ... med-spa with the addition of new Silk Peel skin ... and services. , “Silk Peel is a procedure that ... “As a result it can address issues like acne ... or blemishes.” , Similar to microdermabrasion, Silk Peel ...
(Date:12/24/2014)... December 25, 2014 Today, UWDress.com, the famous ... sleeve wedding gowns, and launched a site-wide wedding gown promotion. ... sleeve wedding gowns in a more unexpected way, the collection ... are popular in the global market, and they are available ... UWDress.com are offered at discounted prices, up to 75% off; ...
(Date:12/24/2014)... The report “Stivarga (Colorectal Cancer) – ... current treatment landscape, unmet needs, current pipeline and commercial ... drug which is used in the treatment of colon ... is also prescribed to patients who suffer from advanced ... is a multi-kinase inhibitor and it blocks many enzymes ...
(Date:12/24/2014)... BambooIndustry.com a famous bamboo flooring company ... the company announces its multiple layer bamboo panel ... these new products. , Bamboo panel is the product ... layer bamboo panel board features high quality selective bamboo ... free. The bamboo panel consists of multiple layers of ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2
... be crumbling under the mounting pressure of dengue. Safdarjung ... several patients being referred to AIIMS and the Red ... patients are given platelets only on the condition of ... exchange for the required platelets. Dr Santosh at the ...
... come up with some valuable information which would definitely ... the mind of an autistic person is blue printed. ... to be affected by autism a developmental disorder typically ... people. ,Lead researcher Dr Michael Murias, from ...
... disorders in women may be diagnosed by examining hair ... It is usually difficult to diagnose eating disorders//, as ... they try to hide it. ,The study ... University (BYU) in U.S. is published in the Rapid ...
... has made a formal application to the European Medicines ... as a viable treatment// for advanced HER2-positive and hormone ... received from the international TAnDEM study which showed that ... from 2.4 months to 4.8 months. ,HER2-positive breast ...
... by NHS hospitals because they are serving meals that are ... catering at 97 health trusts. ,The survey revealed ... food brought in by relatives and friends. Over 37% of ... or tasted disgusting. ,Over a fifth of patients claimed that ...
... John Howard ,the prime minister of Australia, stirred up the ... media for the first time that she had battled ... the National Breast Cancer Centre, she was addressing an august ... all important national breast cancer report.,Over the ‘Pink Ribbon’ breakfast ...
Cached Medicine News:Health News:Mounting Pressure of Dengue in Delhi Hospitals 2Health News:Eating Disorders may be diagnosed by Hair analysis 2Health News:NHS Food Slowing Patient Recovery 2
(Date:12/24/2014)... , Dec. 23, 2014  Lockton Dunning ... of Lockton Companies, announced the addition of Vice ... will join Lockton Dunning,s Pharmacy Consulting team, Excelsior ... of relevant industry experience to the position.  Most ... Market Sales at Diplomat Specialty Pharmacy, where she ...
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Medical Science ... As the key link between the medical device industry ... even more in the coming years as the device ... According to research by benchmarking firm, Best ... can gain an important edge is by harnessing new ...
(Date:12/22/2014)... 22, 2014   TRU-D SmartUVC LLC, producers ... robot, announced today that the General Services Administration has ... 2019.   This newly formed agreement will ... of government purchasers, including Department of Veteran Affairs and ... Security contacts purchasing solutions for the Ebola effort in ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... chemiluminescence assay for the measurement ... serum. Growth Hormone (GH) is ... the anterior pituitary gland under ... hormone releasing hormone (GHRH) and ...
... the sulfate ester of DHEA, derived from ... DHEA in adrenal and extradrenal tissues. DHEA ... the adrenal cortex, and is a precursor ... relatively weak androgenic activity, which for unsulfated ...
... The DHEA-S ELISA kit is based ... separation. An unknown amount of DHEA-S present ... of DHEA-S conjugated with horse-radish peroxidase compete ... DHEA-S antiserum coated onto the wells. After ...
EL-RF-IgM is high sensitivity quantitative rheumatoid factor IgM....
Medicine Products: