Navigation Links
Protein linked to therapy resistance in breast cancer
Date:9/11/2012

development of many types of cancer.

"We hypothesized that resistance to EGFR-TKIs originated, at least in part, from molecular alterations that activated phosphorylation signaling downstream of EGFRs," Furuta says.

Using a unique three-dimensional cell culture assay based on phenotypic reversion that was originally developed by Bissell and her research group, the co-authors of the JCI paper screened for genes involved in EGFR-TKI resistance in both normal and cancerous human breast cell lines. They found that, while normal human breast tissue doesn't produce FAM38A, the protein is highly expressed in cancerous tissue. This was true for every breast cancer cell line they examined, and was particularly pronounced in those cell lines that have been the most resistant to treatment with EGFR-TKIs. Further studies showed that FAM83A interacts with and causes phosphorylation of critical signaling proteins downstream of EGFRs, as the researchers hypothesized. This downstream phosphorylation would act to blunt or negate any therapeutic effects of EGFR-TKIs that took place further upstream.

The results of this research are consistent with clinical data showing that breast cancer patients with high levels of FAM83A have a significantly lower survival rate than patients with low levels of FAM83A. However, while Bissell, Furuta and their colleagues note that a number of questions about FAM83A and other members of the FAM83 protein family remain to be addressed, the importance of these proteins as potential drug targets for therapy seems clear.

"The beauty of this study is that it not only helps explain why some breast cancer patients are resistant to EGFR-TKIs, but it also reveals a whole new family of potential oncogenes that could be a target for all types of cancer, including breast cancer," Bissell says.

Bissell says the results of this study also demonstrate the potential of using 3D phenotypic reversion assays as a new path
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Well-known protein reveals new tricks
2. Binding sites for LIN28 protein found in thousands of human genes
3. Immune system protein could explain pancreatitis
4. In Diabetes, Any Protein in Urine May Signal Heart Risk
5. Protein impedes microcirculation of malaria-infected red blood cells
6. Protein found to regulate red blood cell size and number
7. Toward medicines that recruit the bodys natural disease-fighting proteins
8. New laboratory test assesses how DNA damage affects protein synthesis
9. Stem cells can become anything - but not without this protein
10. Alzheimer protein seems to slow down neurotransmitter production
11. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein linked to therapy resistance in breast cancer
(Date:7/10/2014)... 10, 2014 Register to download the ... streamed the live webinar ‘Capitalizing on the Shifting Sands ... group of several M&A experts in the energy sector ... energy transaction marketplace. These experts shared their insights into ... market in this sector has been revitalized. This roundtable ...
(Date:7/10/2014)... MI (PRWEB) July 10, 2014 ... treatment program that gets clients off to a great ... they can believe in, has launched a new Eating ... , The new section highlights:, , ... and Statistic Manual of Mental Disorders (DSM-IV), including anorexia ...
(Date:7/10/2014)... THURSDAY, July 10, 2014 (HealthDay News) -- Nature, not ... intelligence of individual chimpanzees, a new study finds. ... it comes to cognitive [thinking] abilities in chimpanzees," William ... Atlanta, said in a news release from the journal ... give insight into the evolution of intelligence in humans, ...
(Date:7/10/2014)... News) -- Men who have a vasectomy may be ... study suggests. But the risk is comparatively small, ... the study said more research is needed to determine ... the study, Harvard researchers analyzed data from more than ... starting in 1986. During that time, 6,023 cases of ...
(Date:7/10/2014)... experts on aggression, who research issues ranging from child ... World Meeting of the International Society for Research on ... , Georgia State University is hosting the prestigious world ... continents. , "We are excited to be bringing together ... will help produce fresh ideas about the causes, consequences ...
Breaking Medicine News(10 mins):Health News:Register to Download Merrill DataSite's Report: Capitalizing on the Shifting Sands of the Energy Market 2Health News:Latest A Forever Recovery Launches Eating Disorders Section on Website 2Health News:Like Humans, Chimps' Smarts May Rely on Genes 2Health News:Study Links Vasectomy to Aggressive Prostate Cancer 2Health News:Study Links Vasectomy to Aggressive Prostate Cancer 3Health News:Georgia State hosts national conference on aggression 2Health News:Georgia State hosts national conference on aggression 3
... Study reports high success rate for new test, with results ... A new test can rapidly identify active tuberculosis in people ... about half of all people with active TB, the disease-causing ... new diagnostic tests are needed to help control the spread ...
... Irvine researchers have created a new approach that ... specific cells and organs. Kenneth Longmuir, associate ... professor of anatomy & neurobiology, used liposomes, small ... lipid molecules, as "packages" for the cancer chemotherapeutic ...
... N.Y., SEPT. 25, 2009 Journalists are invited to attend ... health care experts who will review and develop programs that ... The symposium, which will be held Oct. 8 and ... March of Dimes, the American College of Obstetricians and Gynecologists, ...
... testing effects on women and their offspring, , FRIDAY, ... women can cause serious consequences in both mothers and ... treatments. , An update on clinical trials was to ... American Thyroid Association, in Palm Beach, Fla. , "Detection ...
... ... costs, saving time and money , ... Philadelphia, PA (PRWEB) September 25, 2009 -- Observations from Excel ... Philadelphia region, indicate that awareness levels for Direct Access, a law that allows people ...
... causes gastric cancer, it is still controversial that whether ... prevention of gastric cancer. This is especially important for Yamagata ... of gastric cancer in the world. A research ... World Journal of Gastroenterology addresses this question. A ...
Cached Medicine News:Health News:Faster Detection of TB May Be on the Horizon 2Health News:UCI researchers create new strategy for highly selective chemotherapy delivery 2Health News:Experts to review quality improvement programs to prevent preterm birth 2Health News:Experts to review quality improvement programs to prevent preterm birth 3Health News:Studies Evaluate Thyroid Treatment During Pregnancy 2Health News:According to Excel Physical Therapy and Fitness, Awareness Still Low for Law that Allows People to go Directly to a Physical Therapist without a Doctor's Prescription 2Health News:According to Excel Physical Therapy and Fitness, Awareness Still Low for Law that Allows People to go Directly to a Physical Therapist without a Doctor's Prescription 3Health News:Does Helicobacter pylori eradication therapy prevent gastric cancer? 2
(Date:7/10/2014)... 2014 Integrated Silicon Solution, Inc. (Nasdaq: ... analog IC solutions, today announced that it will host ... at 7:00 a.m. Pacific Time (10:00 a.m. Eastern Time) ... 2014 third quarter ended June 30, 2014. ... before 6:50 a.m. Pacific time on July 24, 2014.  ...
(Date:7/10/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... completed the sale to Galderma of all rights to ... by Valeant for $1.4 billion in cash, pursuant to ... completed its acquisition of Galderma. "We ... to a company that is firmly committed to the ...
(Date:7/10/2014)... WOONSOCKET, R.I. , July 10, 2014 CVS ... its board of directors has approved a quarterly dividend of ... The dividend is payable on August 1, 2014, to holders ... Caremark CVS Caremark is dedicated to helping ... integrated pharmacy company in the United States ...
Breaking Medicine Technology:
... DIEGO, May 4, 2011 Volcano Corporation (NASDAQ: ... precision intravascular diagnosis and therapy guidance tools designed to ... said today that it will be participating in the ... Wednesday, May 11. The presentation by Scott ...
... Keryx Biopharmaceuticals, Inc. (NASDAQ: KERX ), ... commercialization of medically important pharmaceutical products for the treatment ... today announced the pricing of an underwritten registered offering ... price of $4.70 per share. The aggregate ...
Cached Medicine Technology:Keryx Biopharmaceuticals, Inc. Prices Common Stock Offering 2
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
... (RAM) is the first visual examination device that ... in eyes with glaucoma, cataract, and macular disease. ... test each eye easily in under 60 seconds. ... Columbia University in New York City, the RAM ...
... The STRATUSOCT is a diagnostic imaging device ... the retina for objective measurement and subjective ... and retinal diseases. The STRATUSOCT images and ... layer and the optic disc using the ...
The Hybrid Fixator consists of Three basic components: rings, wires, clamps. Final fracture reduction can be easily performed after frame assembly....
Medicine Products: