Navigation Links
Protein levels could signal that a child will develop diabetes

AUGUSTA, Ga. Decreasing blood levels of a protein that helps control inflammation may be a red flag that could help children avoid type 1 diabetes, researchers say.

Georgia Health Sciences University researchers are looking at blood levels of interleukin-1 receptor antagonist, or IL-1ra, in children being closely followed because their genes put them at risk for type 1 diabetes. They also are looking at diabetic mice missing IL-1ra to see how the protein deficiency affects immune function and destruction of insulin-producing islet beta cells.

"We want to know if we can use IL-1ra levels to identify children who will soon develop the disease, then use IL-1 inhibitors to prevent it," said Dr. Sharad Purohit, biochemist in the GHSU Center for Biotechnology and Genomic Medicine.

IL-1ra helps reduce inflammation and Purohit's preliminary evidence suggests that low levels predict inflammation is increasing and the immune system is going to attack insulin-producing cells. A three-year, $500,000 grant from the Juvenile Diabetes Research Foundation will help him explore the hypothesis in the blood of about 2,500 children as well as the diabetic mice.

Il-1 inhibitors already are used to treat rheumatoid arthritis, where inflammation destroys joints. Clinical trials are underway in type 1 diabetes and to see if an inhibitor can halt the islet cell destruction that occurs in type 1 diabetes as well.

While acknowledging the inhibitor may improve type 1diabetes outcome, GHSU scientists want to know if it can also be used preventively, said Dr. Jin-Xiong She, Director of the Center for Biotechnology and Genomic Medicine.

IL-1ra competes with its counterpart IL-1beta for the IL-1 receptor. In type 1 diabetes, inflammation-promoting IL-1beta appears to be winning. "It's a balance; it's a competition," She said. "There is always a balance between beta cell production and destruction and any process that can change the balance can push you to disease or help you recover from it. In this case, we believe that knowing the balance is off can actually help prevent disease."

Type 1 diabetes typically presents by puberty, as the body's immune system inexplicably turns against the pancreas' insulin-producing cells. By the time the first symptoms occur, such as increased appetite in the face of significant weight loss, as many as 90 percent of the beta cells may be destroyed, leaving a child facing a lifetime of insulin dependency and often complications such as cardiovascular damage and vision loss. Much like the lifestyle-related type 2 diabetes, the incidence of type 1 is increasing.


Contact: Toni Baker
Georgia Health Sciences University

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
Related Image:
Protein levels could signal that a child will develop diabetes
(Date:11/28/2015)... ... 2015 , ... Pixel Film Studios is back again with ProPanel: Pulse ... are endless. Users have full control over angle of view, speed method, start point, ... sure to get heads to turn. , ProPanel: Pulse offers fully customizable pulsating shape ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... way that they are handling security in light of the recent terrorist attacks in ... an attempt to stop an attack from reaching U.S. soil. Especially around special events ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... were," said an inventor from Hillside, N.J. "Many people catch diseases simply from ... that individuals will always be protected from germs." , He developed the patent-pending ...
(Date:11/27/2015)... ... ... Herpes-only dating community in the world, revealed that over 50% of its members are under ... under the age of 50 – or 67% of the population - are infected with ... infection . , "The data shocks us highly!" said Michelle Li, Co-Founder of the ...
(Date:11/27/2015)... MINNEAPOLIS, Minn. (PRWEB) , ... November 27, 2015 ... ... you start failing. Secura Consultants has prided itself for not only fulfilling the ... best income protection solutions at an affordable price and providing top-tier customer service. ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Nov. 27, 2015  Lannett Company, Inc. (NYSE: ... completed the acquisition of Kremers Urban Pharmaceuticals Inc. ... global biopharmaceuticals company UCB S.A. (Euronext: UCB). ... has acquired KU from UCB for total consideration ... including a customary working capital adjustment, a deduction ...
(Date:11/26/2015)... UTRECHT , Países Bajos, November 26, 2015 /PRNewswire/ ... con la terapia fotodinámica de Bremachlorin para el cáncer ... combina la inmunoterapia con la terapia fotodinámica de Bremachlorin ... Un nuevo enfoque combina la inmunoterapia con la ...   Clinical Cancer Research . --> ...
(Date:11/26/2015)... --> --> ... find optimal contrast weighting of MRI for patients with ... a research agreement with SyntheticMR in order to use SyMRI ... is possible to generate multiple contrast images from a single ... left, thus making it possible to both fine tune images ...
Breaking Medicine Technology: