Navigation Links
Protein level may serve as predictor of severe osteoarthritis
Date:7/29/2009

Osteoarthritis (OA), the most common joint disorder throughout the world and a leading cause of disability, is characterized by pain, impaired joint mobility, reduction of muscular strength and loss of joint function. Unlike most other common diseases, little is known about its origins, and factors predicting a severe disease course have not been identified. A new study, the first to establish a laboratory marker for the risk of severe OA, found that vascular cell adhesion molecule 1 (VCAM-1), was a strong predictor of hip and knee joint replacement due to severe OA. The study was published in the August issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis).

Led by Georg Schett of the University of Erlangen-Nuremberg in Erlangen, Germany, the study involved 912 healthy individuals in Bruneck, Italy, 60 of whom underwent hip or knee replacement surgery due to severe OA in a 15-year follow-up period. Subjects underwent a baseline exam in 1990 and followup exams were performed every five years until 2005. Blood samples were analyzed for VCAM-1, a sialoglycoprotein (a combination sugar and protein) expressed on cells in the cartilage and connective tissue.

The results showed that VCAM-1 levels were substantially elevated in the 60 individuals who underwent joint replacement, with the highest baseline levels seen in those who underwent bilateral joint replacement. "The level of VCAM-1 emerged as a significant predictor of the risk of joint replacement due to severe OA, equaling or even surpassing the effects of age," the authors state. They also note that inclusion of VCAM-1 levels in risk prediction models resulted in a more accurate classification of individuals.

VCAM-1 promotes leukocyte adhesion and homing to sites of inflammation. In chondrocytes (cartilage cells), VCAM-1 expression is induced by inflammatory cytokines (proteins
'/>"/>

Contact: Jennifer Beal
medicalnews@wiley.com
44-124-377-0633
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Protein Clumps May Appear Years Before Memory Problems
2. Human cells secrete cancer-killing protein, UK study finds
3. Cellular Protein Yields Clues to Diabetes, Alzheimers
4. Key Protein Might Shield Brain Cells
5. Brain Imaging (MRI/PET) and Measurements of Proteins in Spinal Fluid May Improve Alzheimers Prediction and Diagnosis
6. Fat-Cell Protein May Reduce Diabetes Risk
7. Cell Protein Could Help Spur Malignancy
8. UAB researchers draft 3-D protein map to aid stroke, cancer research
9. Marking anorexia with a brain protein
10. Lab Study Finds Protein That May Inhibit Cancer Spread
11. Fish protein link to controlling high blood pressure -- new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Yesterday, Senator Holly Mitchell (D-Los ... Olsen (R-Modesto) were honored by the California Healthcare ... biomedical science, medical device and pharmaceutical innovation in ... “2014 Life Sciences Champion” award from CHI President ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and easy ... treat specific body parts and muscle groups. , IsoComforter, ... use patented cold therapy machine with the innovative IsoTube design ... injuries. IsoComforter has become the industry leader in cold ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Payday lending ... vulnerable communities and cause financial distress to the states ... analysts at Howard University’s Center on Race and Wealth. ... in economic activity, payday loans at the same time ...
(Date:1/22/2015)... January 22, 2015 As interest in the ... care gains momentum worldwide, Rev. Eric J. Hall , ... Network (HCCN), will be the keynote speaker on January ... Israel’s public health system. , The conference, “Hope and Resilience: ...
(Date:1/22/2015)... released a new blog post presenting a list of vehicles that ... , Some types of vehicles cannot be covered under an ordinary ... to see if their vehicle qualifies for auto insurance coverage. ... cars that cannot be covered by a plan. Clients have little ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... (Sept. 20, 2007) A Jekyll-Hyde mechanism that both ... the basis for new cancer-fighting drugs. , Scientists in ... that a certain transcription factora protein that binds to ... genes on and offknown to aid in handling stresses ...
... scientist at Leeds whose research is challenging conventional thinking ... has secured funding to further investigate her findings. , ... Sciences has been awarded 80,000 from Heart Research UK ... affecting the heart muscle cell. , For ...
... the agency is doing , , THURSDAY, Sept. 20 ... prescription medicines for health, many are confused and distrustful ... new survey finds. , In fact, many of those ... and Drug Administration approves drugs, and almost half judged ...
... Developments in Solid Organ Transplantation, DALLAS, ... Review",is the focus of a one-day meeting ... Grapevine, Texas. Co-sponsored by the American Society ... Professionals,(NATCO), the conference agenda contains information about ...
... Increase ... SAN ANTONIO, Sept. 20 AT&T Inc. (NYSE: ... portfolio of radio frequency,identification (RFID) tracking offers for health ... operations of hospitals and other,health care facilities. AT&T ...
... MDA stunning discovery by German scientists may make blood ... as washing your hair. In the October print issue ... that the estimated 100,000 hair follicles on each persons ... EPO, the hormone primarily responsible for the creation of ...
Cached Medicine News:Health News:Heat shock proteins are co-opted for cancer 2Health News:Research to shed new light on how statins benefit heart patients 2Health News:Americans Confused About FDA and Drug Safety 2Health News:Americans Confused About FDA and Drug Safety 3Health News:Americans Confused About FDA and Drug Safety 4Health News:Dallas-Area Transplant Meeting Puts Spotlight on Key Issues 2Health News:AT&T Offers 'Network Industry-First' RFID Solution for Health Care Organizations 2Health News:AT&T Offers 'Network Industry-First' RFID Solution for Health Care Organizations 3Health News: New discovery leaves blood-doping athletes scratching their heads 2
(Date:1/22/2015)... ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular disease and ... of the Company,s accomplishments in 2014 and its outlook for ... Dear Fellow Shareholders, We would like to ...
(Date:1/22/2015)... (NASDAQ: TECH ) announced today that it ... Simple Plex platform through its Proteins Platform division under ... the previously acquired CyPlex instrument platform from CyVek. ... technology which integrates an innovatively designed microfluidic cartridge with ...
(Date:1/22/2015)... 22, 2015 Increasing sophistication among enterprise buyers of ... purchasing in 2015, says Moravia CMO, ... study by market research firm Common Sense Advisory, 15 ... their translation and localization needs. "From a language industry ...
Breaking Medicine Technology:Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... Comprehensive Care Corporation (OTC BB: CHCR), a leading ... provider for managed care companies throughout the U.S., today ... Rx Inc., has been selected as the new President ... the healthcare industry, is a graduate of the United ...
... -- Dehaier Medical Systems Ltd. (Nasdaq: ... leader in the development, assembly, marketing and sale of ... announced that it will release financial results for the ... on Monday, November 14, 2011 before the start of ...
Cached Medicine Technology:Comprehensive Care Corporation Names Robert R. Kulbick New President 2Comprehensive Care Corporation Names Robert R. Kulbick New President 3Dehaier Medical to Report Third Quarter 2011 Financial Results on November 14 2
Small bulbous tip with flat sides. Flat serrated handle with polished finish. Overall length: 5.1 inches....
7 mm flattened hook. Flat serrated handle with polished finish. Overall length: 4.9 inches....
Titanium. Small "H" shaped push-pull tip. Shaft angled 45 degrees, 9 mm from tip. Round knurled handle with dull finish. Overall length: 4.8 inches. Most popular size or model....
Right angled 5 mm blunt hook. Overall length: 9.9 inches....
Medicine Products: