Navigation Links
Protein lets brain repair damage from multiple sclerosis, other disorders
Date:6/7/2010

A protein that helps build the brain in infants and children may aid efforts to restore damage from multiple sclerosis (MS) and other neurodegenerative diseases, researchers at Washington University School of Medicine in St. Louis have found.

In a mouse model of MS, researchers found that the protein, CXCR4, is essential for repairing myelin, a protective sheath that covers nerve cell branches. MS and other disorders damage myelin, and this damage is linked to loss of the branches inside the myelin.

"In MS patients, myelin repair occurs inconsistently for reasons that aren't clear," says senior author Robyn Klein, MD, PhD, associate professor of medicine and of neurobiology. "Understanding the nature of that problem is a priority because when myelin isn't repaired, the chances that an MS flare-up will inflict lasting harm seem to increase."

The findings appear online in The Proceedings of the National Academy of Sciences.

Mouse models typically mimic MS symptoms by causing chronic immune cell infiltration in the brain, but, according to Klein, the ongoing immune damage caused by the cells makes it difficult for researchers to focus on what the brain does to repair myelin.

For the study, Klein and first author and postdoctoral fellow Jigisha Patel, PhD, used a non-inflammatory model that involves giving mice food containing cuprizone, a compound that causes the death of cells that form myelin in the central nervous system. After six weeks, these cells, known as oligodendrocytes, are dead, and the corpus callosum, a structure that connects the left and right hemispheres of the brain, has lost its myelin. If cuprizone is then removed from the mouse diet, new cells migrate to the area that restore the myelin by becoming mature oligodendrocytes.

Klein's investigations began with the processes triggered by dying oligodendrocytes while mice are still on the cuprizone diet. The dying cells activate other sup
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Blocking DNA repair protein could lead to targeted, safer cancer therapy
2. US Whey Proteins Market to Reach 472.3 Million Pounds by 2015, According to New Report by Global Industry Analysts, Inc.
3. ‘Protein Lady' Announces New Blog to Promote Importance of Protein-Rich Diet
4. A Protein Links Alzheimers, Down Syndrome
5. Scientists find protein spurs spread of prostate cancer
6. System that predicts protein structures could help researchers design drugs
7. Without this protein, embryonic development halts
8. Study finds key protein controls T-cell proliferation
9. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
10. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
11. A single protein regulates 2 immune pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 05, 2015 , ... Renowned review site BestMillionaireDatingSites.com recently refreshed its list ... has been ranked as the best dating service in the segment. , A representative ... It is essential that people find the right dating platform so that they can ...
(Date:8/4/2015)... ... August 05, 2015 , ... The National Association ... inductee into its VIP Woman of the Year Circle. She is recognized with ... organization exclusively for professional women, boasting more than 700,000 members and over 200 ...
(Date:8/4/2015)... ... ... NOVA Pride , Northern Virginia’s largest and newest LGBTQ nonprofit organization, ... join them in paving “The Road Ahead” at the second annual Northern Virginia Pride ... 2015, from 12-9pm. In order to ensure the success of this important event, NOVA ...
(Date:8/4/2015)... ... 2015 , ... How cool is it to check in at your favorite ... "Now" feature will soon allow you to do just that. , Ahhaa is releasing ... the now feature. , Users will soon get to share what inspires them about ...
(Date:8/4/2015)... , ... August 04, 2015 , ... Statement by Paul ... the introduction of the Mental Health Reform Act of 2015 by Senators ... mental health reform a reality in America. , “This legislation and H.R. ...
Breaking Medicine News(10 mins):Health News:BestMillionaireDatingSites.com Publishes Reviews of the Best Dating Sites for Wealthy Singles 2Health News:NAPW Inducts Deborah Stevens, Executive Assistant to Chairman and CEO at Mirion Technologies, Inc., Into its VIP Woman of the Year Circle 2Health News:NOVA Pride Announces Theme for the 2015 Northern Virginia Pride Festival 2Health News:NOVA Pride Announces Theme for the 2015 Northern Virginia Pride Festival 3Health News:NOVA Pride Announces Theme for the 2015 Northern Virginia Pride Festival 4Health News:Ahhaa App Soon to Release the "Now" Feature 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 3
... a device to monitor diabetics' blood sugar levels and ... on finger-prick blood tests and injections. ,The ... computer to monitor the patient's blood sugar levels and ... a media report. ,The key is the ...
... playing in the park; ,Age is grey,a toothless hag ... four lines reflect the glory of youth and the dismal ... romanticize youth, they shrink from the thought of greying hair, ... infirmities of old age. ,With the changing ...
... of anabolic steroids is linked to criminal activity such ... study published on Monday. // ,The ... of the muscle-building drugs however also revealed that steroid ... violent crimes such as murder, assault, rape and property ...
... Canadians are getting heavier , but a new study by Statistics Canada ... the same pace as they did earlier. //Adults between 18-64 were ... The data showed that they have put on weight steadily , but ... decreased. ,This welcome news is thought to be due to the ...
... have no one to look out for them. They are ... in the community without any money or family of their ... condition that impairs their judgment or ability to communicate. ... baby boomers age. ,There is only one state-funded program ...
... many parts of the world, the moral and legal aspects ... Various methods of inducing //abortions have been used throughout history ... crossed five in North America, who died from toxic shock ... people questioning the safety of the combination of the drugs ...
Cached Medicine News:Health News:Botox – The 'Celebrity' Dru 2Health News:Steroid Use Linked to Crimes 2Health News:Hoosiers Live at the Mercy of Nursing Homes 2Health News:Hoosiers Live at the Mercy of Nursing Homes 3Health News:Medically Induced Abortions (MIAs) Causes More Deaths Due To Infection 2
(Date:8/4/2015)... P&S Market Research releases ... DRO analysis, market segmentation, market size and forecast, ... competitor profiles in: Global Industry Insight: ... Demand Forecast to 2020       (Logo: ... reports with detailed TOC on Global Drug of ...
(Date:8/4/2015)... Aug. 04, 2015 ... the addition of Jain PharmaBiotech,s new report ... to their offering. This report describes ... veterinary medicine and pharmaceuticals as well as improvement ... important in the application of biotechnology to manage ...
(Date:8/4/2015)... Among 1,000 U.S. consumers, the majority (65.3 ... consumers surveyed are aware of prescription savings cards, and ... according to findings from a new survey released today ... on improving the health and well-being of individuals, families ... men and women, ages 21 and older, on their ...
Breaking Medicine Technology:Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 4Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 5Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 2Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 3New Study Finds Consumers are Leaving Money at the Pharmacy 2New Study Finds Consumers are Leaving Money at the Pharmacy 3
... III Clinical Trial of Acetavance(TM) for the Treatment of Fever ... ... of Omigard(TM) Completes Patient Enrollment, SAN DIEGO, May 6 ... focused on in-licensing,developing and commercializing proprietary product candidates principally,for use ...
... 5 Diplomat Specialty Pharmacy,announced today that their ... is now live and being utilized to manage,their ... eNAV(TM) as a,disease management tool for all disease ... Crohn,s Disease,and Chronic Kidney Disease., "Our current ...
Cached Medicine Technology:Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 2Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 3Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 4Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 5Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 6Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 7Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 8Cadence Pharmaceuticals Reports First Quarter 2008 Financial Results and Provides Clinical Program Update 9Diplomat Specialty Pharmacy Develops and Launches Best-In-Class Electronic Navigator (eNAV(TM)) Patient Care System 2
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
... Dimensions (WxDxH): 31.1 x 13.6 x 15.3 ... 22.4 x 20.5 cm, Capacity: 4 - ... x 35 mm bottles, 4 - 150 ... 240 x 80 mm bottle, Power Requirements: ...
... : Temperature controlled oven containing a rotisserie ... incubation of Northern, Southern and Western blots. ... and staining. Use of bottle hybridizations allows ... enhanced sensitivity and reduced reagent costs. Acrylic/polycarbonate ...
... Minifold I system consists of four basic components: ... and metal clamping plate (see diagram). The sample ... producing spots, dots, or slots (see below). All ... as an accessory plate in conjunction with a ...
Medicine Products: