Navigation Links
Protein key to growth of pancreatic cancer
Date:9/28/2010

The protein could provide a target to develop new treatments for the disease or enable earlier diagnosis, say the researchers from Barts and The London School of Medicine and Dentistry. Pancreatic cancer has the lowest survival rate of all cancers due to its lack of symptoms in the early stages, late diagnosis and its resistance to chemotherapy and radiation therapy.

The research funded by the Pancreatic Cancer Research Fund found that nearly three quarters of pancreatic cancer tumours had high levels of a protein known as P110γ. In laboratory experiments, when production of this protein was blocked, the cancer cells stopped growing. The findings are published online today (28 September 2010) in Clinical Cancer Research.

"It is a striking number of patients who present with high levels of P110γ," says Professor of Molecular Pharmacology, Marco Falasca, who led the research. "The fact that P110γ is needed for pancreatic cancer cells to grow shows that it is likely to have a critical role in the progression of the disease, which makes it a potential target for developing new treatments."

The team discovered the link with P110γ by screening both normal and cancerous pancreatic tissue for particular proteins linked to cell proliferation. Up to half of all cancers are linked to a member of one family of these proteins called Phosphoinositide 3-Kinase (PI3K) and the team wanted to see if a link could be made with pancreatic cancer.

Results from the screening show that high levels of P110γ were seen in 72 percent of the cancerous tissue while none could be found in the normal corresponding tissue. And when the researchers blocked production of the P110γ protein, the cancer cells stopped growing. Blocking other members of the same family had no effect, demonstrating a key role for P110γ in the progression of the disease.

"We also found that P110γ is present at high levels in patients with inflammation of the pancreas," adds co-researcher Dr Charlotte Edling.

"Patients with this condition have an increased risk of developing pancreatic cancer so this indicates that P110γ may be involved at an early stage of the disease. We now need to investigate the link between inflammation and cancer of the pancreas in more detail. Hopefully, this could provide a way to enable earlier diagnosis or to assess disease progression."

The team are now working on further research also funded by the Pancreatic Cancer Research Fund looking at whether P110γ is linked to pancreatic cancer's resistance to chemotherapy and whether genetic regulation can explain why P110γ is found at high levels in pancreatic cancer.

Maggie Blanks, CEO of the Pancreatic Cancer Research Fund said: "These initial results are very positive, but there is clearly a lot of further research required. We're pleased to be funding further work by Professor Falasca and his team to help them build on these findings."


'/>"/>

Contact: Patrick Carpenter
p.r.carpenter@qmul.ac.uk
44-020-782-23004
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Nonstick coating of a protein found in semen reduces HIV infection
2. Protein clamps tight to telomeres to help prevent aging ... and support cancer
3. Protein clamps tight to telomeres to help prevent aging...and support cancer
4. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
5. Function found for Alzheimers protein
6. Misfolded neural proteins linked to autism disorders
7. Will extra protein and exercise help dialysis patients? U of I profs get $2.1 million to find out
8. Researchers zero in on protein that destroys HIV
9. Munich researchers demonstrate rocking movement in the anti-stress protein Hsp90
10. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
11. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
Breaking Medicine Technology: