Navigation Links
Protein key to growth of pancreatic cancer
Date:9/28/2010

The protein could provide a target to develop new treatments for the disease or enable earlier diagnosis, say the researchers from Barts and The London School of Medicine and Dentistry. Pancreatic cancer has the lowest survival rate of all cancers due to its lack of symptoms in the early stages, late diagnosis and its resistance to chemotherapy and radiation therapy.

The research funded by the Pancreatic Cancer Research Fund found that nearly three quarters of pancreatic cancer tumours had high levels of a protein known as P110γ. In laboratory experiments, when production of this protein was blocked, the cancer cells stopped growing. The findings are published online today (28 September 2010) in Clinical Cancer Research.

"It is a striking number of patients who present with high levels of P110γ," says Professor of Molecular Pharmacology, Marco Falasca, who led the research. "The fact that P110γ is needed for pancreatic cancer cells to grow shows that it is likely to have a critical role in the progression of the disease, which makes it a potential target for developing new treatments."

The team discovered the link with P110γ by screening both normal and cancerous pancreatic tissue for particular proteins linked to cell proliferation. Up to half of all cancers are linked to a member of one family of these proteins called Phosphoinositide 3-Kinase (PI3K) and the team wanted to see if a link could be made with pancreatic cancer.

Results from the screening show that high levels of P110γ were seen in 72 percent of the cancerous tissue while none could be found in the normal corresponding tissue. And when the researchers blocked production of the P110γ protein, the cancer cells stopped growing. Blocking other members of the same family had no effect, demonstrating a key role for P110γ in the progression of the disease.

"We also found that P110γ is present at high levels in patients with inflammation of the pancreas," adds co-researcher Dr Charlotte Edling.

"Patients with this condition have an increased risk of developing pancreatic cancer so this indicates that P110γ may be involved at an early stage of the disease. We now need to investigate the link between inflammation and cancer of the pancreas in more detail. Hopefully, this could provide a way to enable earlier diagnosis or to assess disease progression."

The team are now working on further research also funded by the Pancreatic Cancer Research Fund looking at whether P110γ is linked to pancreatic cancer's resistance to chemotherapy and whether genetic regulation can explain why P110γ is found at high levels in pancreatic cancer.

Maggie Blanks, CEO of the Pancreatic Cancer Research Fund said: "These initial results are very positive, but there is clearly a lot of further research required. We're pleased to be funding further work by Professor Falasca and his team to help them build on these findings."


'/>"/>

Contact: Patrick Carpenter
p.r.carpenter@qmul.ac.uk
44-020-782-23004
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Nonstick coating of a protein found in semen reduces HIV infection
2. Protein clamps tight to telomeres to help prevent aging ... and support cancer
3. Protein clamps tight to telomeres to help prevent aging...and support cancer
4. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
5. Function found for Alzheimers protein
6. Misfolded neural proteins linked to autism disorders
7. Will extra protein and exercise help dialysis patients? U of I profs get $2.1 million to find out
8. Researchers zero in on protein that destroys HIV
9. Munich researchers demonstrate rocking movement in the anti-stress protein Hsp90
10. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
11. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... Mass. (PRWEB) , ... February 20, 2017 , ... ... delivery for regulated industries, announced Biscom Document Router (BDR), the first IoT device ... resolution lab diagnostics and imaging. Biscom will debut BDR at HIMSS17 ...
(Date:2/20/2017)... ... 2017 , ... Houston dentist , Dr. Nazari, announces ... his office, Antoine Dental Center. Emergency dentistry encompasses many treatments for emergencies affecting ... for serious complications and often experience severe pain. Not only does prompt treatment ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... to purchase a new ultrasound-enhanced thrombolysis machine, a state-of-the-art device that breaks up ... facilitated by the Pepin Family Foundation. , “We greatly appreciate this gift from ...
(Date:2/19/2017)... , ... February 19, 2017 , ... ... to result in better care, and MEDfx and the Delaware Health Information Network ... Delaware. , As the nation’s first state-wide health information exchange, DHIN stores and ...
(Date:2/18/2017)... ... 2017 , ... Butler Mobility invited Ken Matthews to visit its manufacturing facility ... Ken was impressed with the safety and reliability of the Stannah Stairlift as well ... This endorsement by Ken Matthews can be heard on News Radio WHP 580 ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , Feb. 20, 2017 Provides understanding ... and agreements entered into by the worlds leading ... https://www.reportbuyer.com/product/3605699/ Description The Global Renal Failure ... understanding and access to partnering deals and agreements ... - Trends in partnering deals ...
(Date:2/20/2017)... Systems Magnetic resonance imaging (MRI) ... the organs and tissues in the body with the ... technique does not use ionizing radiation either for the ... of cancer. MRI is used for a variety of ... orthopedics. Hence, MRI helps in the diagnosis and treatment ...
(Date:2/20/2017)... report analyzes the worldwide markets for Drug-Eluting Stents in US$ Million. ... Canada , Japan , Europe ... , and Rest of World. Read the ... ... 2015 through 2022. Also, a six-year historic analysis is provided for ...
Breaking Medicine Technology: