Navigation Links
Protein key to growth of pancreatic cancer

The protein could provide a target to develop new treatments for the disease or enable earlier diagnosis, say the researchers from Barts and The London School of Medicine and Dentistry. Pancreatic cancer has the lowest survival rate of all cancers due to its lack of symptoms in the early stages, late diagnosis and its resistance to chemotherapy and radiation therapy.

The research funded by the Pancreatic Cancer Research Fund found that nearly three quarters of pancreatic cancer tumours had high levels of a protein known as P110γ. In laboratory experiments, when production of this protein was blocked, the cancer cells stopped growing. The findings are published online today (28 September 2010) in Clinical Cancer Research.

"It is a striking number of patients who present with high levels of P110γ," says Professor of Molecular Pharmacology, Marco Falasca, who led the research. "The fact that P110γ is needed for pancreatic cancer cells to grow shows that it is likely to have a critical role in the progression of the disease, which makes it a potential target for developing new treatments."

The team discovered the link with P110γ by screening both normal and cancerous pancreatic tissue for particular proteins linked to cell proliferation. Up to half of all cancers are linked to a member of one family of these proteins called Phosphoinositide 3-Kinase (PI3K) and the team wanted to see if a link could be made with pancreatic cancer.

Results from the screening show that high levels of P110γ were seen in 72 percent of the cancerous tissue while none could be found in the normal corresponding tissue. And when the researchers blocked production of the P110γ protein, the cancer cells stopped growing. Blocking other members of the same family had no effect, demonstrating a key role for P110γ in the progression of the disease.

"We also found that P110γ is present at high levels in patients with inflammation of the pancreas," adds co-researcher Dr Charlotte Edling.

"Patients with this condition have an increased risk of developing pancreatic cancer so this indicates that P110γ may be involved at an early stage of the disease. We now need to investigate the link between inflammation and cancer of the pancreas in more detail. Hopefully, this could provide a way to enable earlier diagnosis or to assess disease progression."

The team are now working on further research also funded by the Pancreatic Cancer Research Fund looking at whether P110γ is linked to pancreatic cancer's resistance to chemotherapy and whether genetic regulation can explain why P110γ is found at high levels in pancreatic cancer.

Maggie Blanks, CEO of the Pancreatic Cancer Research Fund said: "These initial results are very positive, but there is clearly a lot of further research required. We're pleased to be funding further work by Professor Falasca and his team to help them build on these findings."


Contact: Patrick Carpenter
Queen Mary, University of London

Related medicine news :

1. Nonstick coating of a protein found in semen reduces HIV infection
2. Protein clamps tight to telomeres to help prevent aging ... and support cancer
3. Protein clamps tight to telomeres to help prevent aging...and support cancer
4. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
5. Function found for Alzheimers protein
6. Misfolded neural proteins linked to autism disorders
7. Will extra protein and exercise help dialysis patients? U of I profs get $2.1 million to find out
8. Researchers zero in on protein that destroys HIV
9. Munich researchers demonstrate rocking movement in the anti-stress protein Hsp90
10. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
11. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
Post Your Comments:
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   ... Spaulding Rehabilitation Network,s Dean Center for Tick ... Physical Medicine and Rehabilitation, MIT Hacking Medicine, University ... for Innovation, today announced the five finalists of ... for Lyme disease.  More than 100 scientists, clinicians, ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: