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Protein is involved with colon cancer cell's ability to invade other cells
Date:6/27/2013

ers also looked at another protein that influences cell survival, migration and invasion, called ERK, which has higher activity in cancer cells. Lowering the levels of km23-1, reduced ERK activation. Decreased ERK activity relates to the production of TGF-beta and cell movement.

"If we can block km23-1, we can stop the spread of colon cancer earlier," Mulder said. "But we would also affect other important functions of the protein. In order to address this issue, we are now trying to find the specific partners of km23-1 that contribute to the invasion of the cancer cells. Then we can design more precise therapeutic agents that target critical regions of km23-1 rather than eliminating the entire protein."

Researchers used a cell model that represents a unique class of colon cancer that needs further study. This model features cells that move as groups, and not singularly.

"The type of cell movement, or migration, has important implications with respect to the detection of tumor cells in the blood of cancer patients, as well as for the development of new treatments," Mulder said.


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Contact: Matthew Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2

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