Navigation Links
Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
Date:3/5/2008

ues that promote tumor growth and metastasis.

Groundbreaking work by Hendrix and colleagues is elucidating how, by becoming more like unspecialized stem cells, aggressive melanoma cells gain enhanced abilities to migrate, invade and metastasize while remaining virtually undetected by the immune system.

Hendrix and co-researchers previously demonstrated that a three-dimensional matrix conditioned by hESCs induced metastatic melanoma cells to revert to a normal, skin cell-like type with the ability to form colonies in the manner of hESCs (Postovit and Seftor et al, Stem Cells 24:501-505, 2006).

"This observation allowed us to appreciate the powerful influence of the hESC microenvironment on the reprogramming of metastatic melanoma cells," Hendrix said.

In subsequent experiments, Hendrix, Postovit and co-researchers found that aggressive melanoma and breast cancer produce a "morphogenic" protein called Nodal, which is essential for human embryonic stem cell pluripotency (Topczewska et al, Nature Medicine 12:925-932, 2006). Other researchers have found that Nodal also is present in testicular cancer.

"Thus, Nodal may serve as a prognostic marker of aggressive behaviors in human cancers," Hendrix said.

As described in the PNAS study, the Lefty protein inhibits production of Nodal and therefore plays a major role in embryonic cell differentiation and development - under normal circumstances.

Hendrix and colleagues discovered that metastatic tumor cells do not express Lefty, allowing them to overproduce Nodal in an unregulated manner.

However, when the group exposed metastatic tumor cells to the microenvironment of hESCs containing Lefty, they witnessed dramatically reduced Nodal expression (production) in these cancer cells together with decreased tumor cell growth and invasiveness and an increase in apoptosis, or programmed cell suicide.

Although exposure to a hESC microenvironment inhibited N
'/>"/>

SOURCE Northwestern University
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Sticky blood protein yields clues to autism
2. Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
3. Embryonic Stem Cell Protein Inhibits Melanoma
4. Protein in embryonic stem cells control malignant tumor cells
5. Novel mechanism found that may boost impaired function of leukemia protein
6. Cancer-related protein may play key role in Alzheimers disease
7. Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells
8. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
9. Urine protein may be present before hypertension diagnosis in at-risk adolescents
10. VBI, Mayo Clinic investigate link between fungal proteins, innate immunity and asthma
11. Researchers identify and shut down protein that fuels ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas Sale, ... has chosen their best-selling lace wedding dresses, vintage bridesmaid ... season. , Now, BellasDress.com features popular women’s dresses, ... discount prices. The business hopes everyone can have a ... , “All our elegant products are made with exquisite ...
(Date:12/25/2014)... Helen Harris’ RP (Retinitis Pigmentosa) International ... after an 8 year battle with breast cancer. ... in her home in Woodland Hills California after an ... , As the founder and volunteer President ... and championed many of today's greatest breakthroughs in restoring ...
(Date:12/25/2014)... 25, 2014 Recently, LunaDress.co.uk has updated its blog ... related accessories. Now, all of the models at LunaDress.co.uk come with ... groom lifts the wedding veil can turn out to be a ... A wedding veil can always bring surprise to a wedding. On ... how to choose veils for a big day . , ...
(Date:12/25/2014)... The risk of burns from fires and cooking accidents ... extra cautious, an expert says. "Between Thanksgiving and ... patients coming in with burns," said Dr. Steven Sandoval, ... Center of Stony Brook University Hospital in New York. ... if not careful, could quickly turn tragic," Sandoval said ...
(Date:12/25/2014)... 24, 2014 (HealthDay News) -- Among early stage breast ... than half of one percent will eventually develop leukemia ... reveals. The finding comes from a review of ... and 2007, and it suggests that the risk for ... experts had previously thought. "The frequency of bone ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... TUESDAY, April 28 (HealthDay News) -- The number of confirmed ... climb Tuesday, to 64, with all the bulk of the ... that had previously reported 18 cases of the infectious disease, ... in the United States in five states," Dr. Richard Besser, ...
... scientists, in partnership with 30 research institutions across the country, ... in autistic children. And when researchers scrutinized the activity of ... discovered that it is most active in key regions that ... , Published April 28 in the advance online edition of ...
... Honored by Massachusetts LegislatureBEDFORD, Mass., April 28 ... visual impairment or his diabetes keep him from sailing ... members from the Carroll Center for the Blind in ... Division at the 2009 Blind Sailing World Championship Regatta ...
... of physicians say there is a risk for a ... national study among 1,039 physicians revealed that a majority ... of risk that the Swine Flu will result in ... )The study was conducted by HCD Research ...
... Expert Available to Comment on Swine Flu Outbreak ... AmeriCares, a nonprofit humanitarian aid organization, is ... several Texas health clinics treat and prevent the ... and other vital supplies. Some clinics report patients ...
... CRW.L), a leader in financial improvement software solutions for the ... Verni as Non-Executive Director. Verni starts his appointment on May ... leading Software as a Service (SAAS) company focused on the ... of Sage Software, Inc., and a member of the Board ...
Cached Medicine News:Health News: U.S. Swine Flu Cases Surpass 60 2Health News: U.S. Swine Flu Cases Surpass 60 3Health News:World's largest DNA scan for autism uncovers new gene variant for disorder 2Health News:World's largest DNA scan for autism uncovers new gene variant for disorder 3Health News:Insulet Applauds Employee for Bronze Medal Performance in World Blind Sailing Championships 2Health News:Swine Flu Outbreaks Cause Concern among U.S. Physicians 2Health News:Swine Flu Outbreaks Cause Concern among U.S. Physicians 3Health News:Craneware Appoints New Non-Executive Director 2
(Date:12/24/2014)... China , Dec. 23, 2014 ... pharmaceutical company that specializes in patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) today announced that the Company ... its Good Manufacturing Practice (GMP) certificate of TPI,s ... Drug Administration,s (CFDA). The public notice period is ...
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Medical Science ... As the key link between the medical device industry ... even more in the coming years as the device ... According to research by benchmarking firm, Best ... can gain an important edge is by harnessing new ...
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014 ... into expanded corporate offices in Aliso Viejo ... announced that due to the tremendous growth and worldwide ... needed. Sales of patented SnoreRx, the anti snore cure ... offices. He said, "We are now in 23 ...
Breaking Medicine Technology:TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... 2011 Reportlinker.com announces that a ... in its catalogue: ... Alternatives to Needle-Based Systems for Vaccine ... http://www.reportlinker.com/p0590267/Needle-Free-Drug-Delivery-The-Market-for-Alternatives-to-Needle-Based-Systems-for-Vaccine-and-Biologics.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology The line ...
... WOONSOCKET, R.I., Aug. 16, 2011 Medicare Part D ... to pay 100 percent of previously subsidized prescription costs, ... they are to switch to more affordable or generic ... Medicine concludes. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO) ...
Cached Medicine Technology:Needle-Free Drug Delivery: The Market for Alternatives to Needle-Based Systems for Vaccine and Biologics 2Needle-Free Drug Delivery: The Market for Alternatives to Needle-Based Systems for Vaccine and Biologics 3Needle-Free Drug Delivery: The Market for Alternatives to Needle-Based Systems for Vaccine and Biologics 4Needle-Free Drug Delivery: The Market for Alternatives to Needle-Based Systems for Vaccine and Biologics 5CVS Caremark, Harvard and Brigham and Women's Researchers Say Medicare 'Donut Hole' Can Lead to a Decrease in Medication Adherence 2CVS Caremark, Harvard and Brigham and Women's Researchers Say Medicare 'Donut Hole' Can Lead to a Decrease in Medication Adherence 3
Angled for easy insertion into side port incision for manipulation of nucleus. Flat, paddle like tip for placement in groove to crack the nucleus for emulsification....
Excellent during IOL insertion while pushing the trailing haptic into position. Gently curved shaft and round handle....
Angled shaft with 1.5 mm tip designed to efficiently perform the "Stop and Chop" technique. Round knurled handle. Most popular size or model....
Smaller than the kuglen hook, this manipulator offers excellent grasping or lifting of the nucleus. Blunt finger-like 0.5 mm two-prong tip. Round knurled handle with dull finish. Angled....
Medicine Products: