Navigation Links
Protein impedes microcirculation of malaria-infected red blood cells
Date:8/30/2012

CAMBRIDGE, MA -- When the parasite responsible for malaria infects human red blood cells, it launches a 48-hour remodeling of the host cells. During the first 24 hours of this cycle, a protein called RESA undertakes the first step of renovation: enhancing the stiffness of the cell membranes.

That increased rigidity impairs red blood cells' ability to travel through the blood vessels, especially at fever temperatures, according to a new study from researchers at MIT, the Institut Pasteur and the Korea Advanced Institute of Science and Technology (KAIST).

This marks the first time that scientists have identified the specific role of the RESA protein in modulating blood circulation in an environment that mimics physiological conditions, and could help researchers determine new strategies to combat malaria, which infects an estimated 300 to 500 million people worldwide each year.

The study coordinated by MIT's Ming Dao, a principal research scientist in the Department of Materials Science and Engineering (DMSE); Monica Diez Silva, a research scientist in DMSE; and YongKeun Park, an assistant professor of physics at KAIST appears Aug. 30 in Scientific Reports, an online journal of Nature.

Other MIT authors are Subra Suresh, former dean of the MIT School of Engineering and Vannevar Bush Professor of Engineering who is currently on leave from MIT serving as the director of the National Science Foundation; Jongyoon Han, an associate professor in the Department of Electrical Engineering and Computer Science (EECS); Sha Huang, an EECS graduate student; recent PhD recipient Hansen Bow; and the late Michael Feld, professor of physics.

This paper is the culmination of a collaboration between MIT and Institut Pasteur begun in 2004 when Suresh spent a sabbatical in Paris. The new results on dynamic microcirculation significantly extend earlier static experiments by the Suresh lab and the Pasteur team published in
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... Arlington, VA (PRWEB) November 26, 2014 ... foster greater effectiveness in containing and stopping Ebola, ... long-term stability in healthcare systems in West Africa. ... Care Systems to Stop Ebola: Anthropologists Offer Insights,” ... held by the American Anthropological Association (AAA), Fri., ...
(Date:11/26/2014)... Aurora, CO (PRWEB) November 26, 2014 For ... fast, the new LES MILLS BODYPUMP™ classes at ... be just the workout they've been looking for. The 45- ... with CU Anschutz Health and Wellness Center fitness club memberships. ... muscles. The workouts are fast-paced and are aimed at fast ...
(Date:11/26/2014)... 26, 2014 One of the most ... some point in her life is choosing the ideal ... platform for ladies to purchase high quality outfits. Today, ... dresses. People now can pick their suitable bridesmaid gowns ... dresses always make ladies look scintillating and highlight all ...
(Date:11/26/2014)... 25, 2014 (HealthDay News) -- The number of emergency department ... in 2010 to a record 136 million in 2011, according ... The findings also showed that fewer people were going to ... identified as needing medical care within two hours of arriving ... according to the research. Sixty percent of patients arrived ...
(Date:11/26/2014)... News) -- Parents need to take an active role ... warns. Parents must make sure sports-playing teens have ... Dodick, chair of the American Migraine Foundation and a ... Medicine in Scottsdale, Ariz. in an American Migraine Foundation, ... coach involved with teens sports needs to have appropriate ...
Breaking Medicine News(10 mins):Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 2Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 3Health News:LES MILLS BODYPUMP™ classes come to the University of Colorado Anschutz Health and Wellness Center 2Health News:Royal Blue Bridesmaid Dresses Now Are Available for Christmas at BellasDress.com 2Health News:ER Visits on the Rise, Study Reports 2Health News:Parents Need to Take Lead on Teen Concussion Prevention 2
... May 24 (HealthDay News) -- Japanese-American men who don,t eat ... of stroke later in life, according to a new, long-term ... in Hawaii. They were between the ages of 45 ... first examined and interviewed about their eating habits. During ...
... Our cells breathe and digest, as does the organism as ... contained in the nutrients they ingest, before discarding the waste, ... for the cells. Its digestion occurs in the cytoplasm, in ... pyruvate and a small amount of energy. Pyruvate is then ...
... the benefits of a virtual exercise partner shows the presence ... the motivation by as much as 100 percent ... of Michigan State University,s Department of Kinesiology shows women taking ... with a virtual partner, results the authors said can be ...
... Fatigue is a common problem among surgery residents, a small, ... that fatigue may play a major role in medical errors, ... Program and Massachusetts General Hospital in Boston, and colleagues. ... average of 5.3 hours a day, with average individual amounts ...
... 2012) -- A team of scientists at McMaster University ... cells in the human while avoiding the toxic side-effects ... our finding is the way this human-ready drug actually ... that are non-cancerous," said Mick Bhatia, the principal investigator ...
... WEDNESDAY, May 23 (HealthDay News) -- The risk of sudden ... more slowly through the lower chambers of the heart, a ... and cause it to pump blood through its four chambers. ... measured using an electrocardiogram (ECG). The waves traveling through the ...
Cached Medicine News:Health News:The cells' petrol pump is finally identified 2Health News:Cyber exercise partners help you go the distance 2Health News:McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones 2Health News:Study Spots Early Warning Signal for Sudden Cardiac Death 2
(Date:11/26/2014)... , Nov. 25, 2014 Jazz Pharmaceuticals plc (Nasdaq: ... its corporate presentations at two upcoming investor conferences.  ... UK on Tuesday, December 2, 2014 at 6:45 a.m. ... president and head of EUSA International, will provide an overview of ... th Annual Piper Jaffray Healthcare Conference in New ...
(Date:11/24/2014)... Inc. (NYSE: CRY ), a leading medical device ... announced today that it will participate in the upcoming 26 ... 3, 2014 at The New York Palace Hotel in ... webcast of the Company,s presentation is scheduled to begin at ... company by Pat Mackin , President and Chief Executive ...
(Date:11/24/2014)... -- Marta Rendon, MD, founder of the Rendon Center for Dermatology ... international key opinion leader in dermatology, was one of only ... to attend the international Aesthetic Experts Summit held ... at this gathering of over 600 physicians from 57 countries, ... experts from Asia and ...
Breaking Medicine Technology:Jazz Pharmaceuticals Announces Participation in Two Investor Conferences 2CryoLife to Present at 26th Annual Piper Jaffray Healthcare Conference 2CryoLife to Present at 26th Annual Piper Jaffray Healthcare Conference 3Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3
... Arriva Medical, a leading national provider of diabetic ... in a transaction valued at approximately $23 million.  The ... closing, and contingent payments which are expected to total ... customer base of approximately 120,000 active customers.  As part ...
... 2012 The Providence Service Corporation (Nasdaq: ... for the fourth quarter and year ended December 31, ... February 15, 2012.Fourth Quarter 2011 ResultsFor the fourth quarter ... an increase of 11.4% from $219.3 million in the ...
Cached Medicine Technology:Providence Service Corporation Reports 2011 Results 2Providence Service Corporation Reports 2011 Results 3Providence Service Corporation Reports 2011 Results 4Providence Service Corporation Reports 2011 Results 5Providence Service Corporation Reports 2011 Results 6Providence Service Corporation Reports 2011 Results 7Providence Service Corporation Reports 2011 Results 8
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: