Navigation Links
Protein helps parasite survive in host cells
Date:12/28/2010

Researchers at Washington University School of Medicine in St. Louis have learned why changes in a single gene, ROP18, contribute substantially to dangerous forms of the parasite Toxoplasma gondii. The answer has likely moved science a step closer to new ways to beat Toxoplasma and many other parasites.

In a study published in Cell Host & Microbe, scientists show that the ROP18 protein disables host cell proteins that would otherwise pop a protective bubble the parasite makes for itself. The parasite puts the bubble on like a spacesuit by forming a membrane around itself when it enters host cells. This protects it from the hostile environment inside the cell, which would otherwise kill it.

"If we can find therapies that block ROP18 and other parasite proteins like it, that could give the host the upper hand in the battle against infection," says first author Sarah Fentress, a graduate student in the laboratory of L. David Sibley, PhD, professor of molecular microbiology.

Infection with Toxoplasma, or toxoplasmosis, is most familiar to the general public from the recommendation that pregnant women avoid changing cat litter. Cats are commonly infected with the parasite, as are some livestock and wildlife.

"The exact role of ROP18 and related proteins in human disease remains to be studied," says Sibley. "But mice are natural hosts of Toxoplasma, so studies in laboratory mice are relevant to the spread of infection."

Epidemiologists estimate that as many as one in every four humans is infected with Toxoplasma. Infections typically cause serious disease only in patients with weakened immune systems. In some rare cases, though, infection in patients with healthy immune systems leads to serious eye or central nervous system disease, or congenital defects or death in the fetuses of pregnant women.

In the new study, Fentress showed that the ROP18 protein binds to a class
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Human protein improves muscle function of muscular dystrophy mice
2. UCLA researchers uncover new cell biological mechanism that regulates protein stability in cells
3. Protein disables p53, drives breast cells toward cancer transition
4. Protein offers new clue to cause and treatment for kidney disease
5. Protein targeted to stop melanoma tumor growth
6. New Test Links Blood Protein to Heart Disease, Diabetes Risk
7. Scientists Find Protein That May Help Control Prostate Cancer
8. Neurological protein may hold the key to new treatments for depression
9. More Protein, Fewer Refined Carbs May Keep Weight Off
10. Protein found to predict brain injury in children on ECMO life support
11. Protein in the urine: A warning sign for cognitive decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein helps parasite survive in host cells
(Date:10/2/2014)... Dennis Thompson HealthDay ... Forty-two states and the District of Columbia now have a ... respiratory illness that has been infecting children since the ... with the virus have died in recent weeks, but it,s ... played in those deaths, officials said. Health officials are ...
(Date:10/1/2014)... today in the Journal of the American Medical ... years with moderate or severe chronic knee pain, acupuncture ... University of Melbourne randomly assigned 282 patients (50 years ... or sham or pretend laser treatment. , Treatments ... blinded to laser and sham (inactive) laser acupuncture. , ...
(Date:10/1/2014)... that encourages people to keep their "eyes on the ... exercise. When walking, staying focused on a specific target ... and help people walk there faster, psychology researchers have ... while looking around the environment naturally, offers a new ... are less interested in exercise if physical activity seems ...
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new ... insurance prices for smokers. , Smoking will always have ... quotes is the best method to find affordable coverage. ... who need coverage. , Whole life insurance premiums ... policy. Since the coverage is permanent, the initial ...
(Date:10/1/2014)... October 01, 2014 Join the more than ... Disorder Treatment Center’s first ever charity golf tournament to benefit ... with eating disorders who cannot afford treatment. The tournament will ... in Eureka, Mo. , The day-long event starts with ... reception and award dinner will begin at 5 p.m. and ...
Breaking Medicine News(10 mins):Health News:42 States Reporting Respiratory Virus That Targets Kids 2Health News:42 States Reporting Respiratory Virus That Targets Kids 3Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3
... at PA Velodrome BREINIGSVILLE, Pa., April 26 In just ... Paradysz bested the 24-hour track record at the Valley ... a new record of 416.09 miles (669.63 kilometers) biked in ... was set in 1980. Paradysz undertook this daunting physical challenge ...
... A team of scientists at The Campbell Family ... Hospital and international collaborators have discovered how to trigger ... included in new clinical trials that use a patient,s ... online today in Nature Medicine (DOI: 10.1038/nm.1953), ...
... found they also reduced chances of erectile dysfunction , , ... statins help prevent prostate cancer and reduce the risk ... there seems to be mounting evidence that there may ... treatment or prostate cancer prevention," said Dr. Lionel L. ...
... Inc. and the California Family Health Council have released a statewide ... ... (PRWEB) April 26, 2009 -- ISIS, Inc., has partnered with the ... Health (CDPH), STD Control Branch, to launch a statewide text messaging ...
... statins may reduce inflammation in prostate tumors, possibly hindering ... in the Duke Prostate Center. , "Previous studies have ... lower incidence of advanced prostate cancer, but the mechanisms ... largely unknown," said Lionel Baez, M.D., a researcher in ...
... red under blue light allows physicians to more easily ... which these cancers come back, says a Mayo Clinic ... international clinical trial. , VIDEO ALERT: Additional audio and ... Lance Mynderse describing the research, are available on the ...
Cached Medicine News:Health News:Father Breaks Cycling Record To Honor Daughter's Fight Against Lupus 2Health News:Scientists discover how to improve immune response to cancer at Princess Margaret Hospital 2Health News:Statins Guard Against Prostate Cancer 2Health News:Statins Guard Against Prostate Cancer 3Health News:Statins Guard Against Prostate Cancer 4Health News:HookUp: Sexual Health Info Text Messaging Service for California Youth Launches 2Health News:Statins may exert influence on prostate cancer growth by reducing inflammation 2Health News:Mayo Clinic researcher says improved detection of bladder tumors reduces cancer recurrence 2Health News:Mayo Clinic researcher says improved detection of bladder tumors reduces cancer recurrence 3
(Date:10/1/2014)... October 1, 2014 Sophia Genetics, ... Sequencing (NGS) data analysis, today launches a unique CFTR ... analysis in a single NGS experiment. The CE-IVD marked ... of variants in a single NGS experiment with clinical ... not been possible to simultaneously analyse all relevant CFTR ...
(Date:9/30/2014)... , Sept. 30, 2014  Hologic, Inc. (NASDAQ: ... MacMillan , Hologic,s President and Chief Executive Officer, will ... on October 1, the first day of Breast Cancer ... the Company,s campaign focused on the important benefits of ... by the FDA as clinically superior to traditional mammography. ...
(Date:9/30/2014)... 2014 STUDY OBJECTIVES The objective ... provide an overview of the current and future ... The key objective is to present a comprehensive ... an important tool in the treatment of various ... strategies within the protein therapeutics market, which includes ...
Breaking Medicine Technology:Sophia Genetics Launches Full CFTR Analysis in Single Clinical Grade NGS Experiment 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4
... Week announced today that it has entered into an ... the #1 source for Orthopedic Industry News, to more ... most prominent investors and decision makers around the world. ... central bankers, finance ministers and others.  By adding Orthopedics ...
... ADDISON, Texas, June 14, 2011 ULURU Inc. ... on the development of a portfolio of wound management and ... convertible debt financing with Kerry P. Gray, the Company,s Chairman, ... the funds for general corporate purposes. The convertible ...
Cached Medicine Technology:Orthopedics This Week Now on Bloomberg 2ULURU Inc. Raises $140,000 in Convertible Debt Offering 2
Dust covers for a variety of Zeiss microscopes...
These objectives have more contrast than the DLL objectives for enhanced contrast with tissue culture specimens. These objectives are designed for use on inverted microscopes and therefore their mark...
... Axiovert 40 inverted ... you have ever expected from a microscope in ... outstanding quality, and functionality. Axiovert 40 has been ... safe as possible thus increasing the efficiency ...
... TE2000E is an advanced inverted microscope for ... imaging ports, high resolution CFI60 optics, and ... imaging workstation. In addition, its super-nanoprecision z-axis ... is perfect for precise imaging in 3D. ...
Medicine Products: