Navigation Links
Protein from pregnancy hormone may prevent breast cancer
Date:11/24/2009

PHILADELPHIA Researchers have found that hormones produced during pregnancy induce a protein that directly inhibits the growth of breast cancer. This protein, alpha-fetoprotein (AFP), may serve as a viable, well-tolerated agent for the treatment and prevention of breast cancer, according to findings published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

"Hormones in pregnancy, such as estrogen, all induce AFP, which directly inhibits the growth of breast cancer," said lead researcher Herbert Jacobson, Ph.D., who is a basic breast cancer researcher in the Center for Immunology and Microbial Diseases and in the Department of Obstetrics, Gynecology and Reproductive Sciences at Albany Medical College, N.Y.

"The body has a natural defense system against breast cancer," he added. "AFP needs to be safely harnessed and developed into a drug that can be used to protect women from breast cancer."

Recent studies have shown that hormones released during pregnancy, such as estrogen, progesterone and human chorionic gonadotropin, reduce a women's risk for breast cancer. AFP is a protein normally produced by the liver and yolk sac of a fetus. Jacobson and colleagues sought to determine whether administering pregnancy hormones to carcinogen-exposed rats led them to produce AFP, which in turn produces the protective effect of pregnancy in the absence of pregnancy.

Results from this study showed that treatment with estrogen plus progesterone, estrogen alone or human chorionic gonadotropin reduced the incidence of mammary cancers in rats. Furthermore, the researchers noted that each of these treatments elevated the serum level of AFP and that AFP directly inhibited the growth of breast cancer cells growing in culture, suggesting that these hormones of pregnancy are preventing breast cancer through their induction of AFP.

Cancer Prevention Research Editorial Board Member Pow
'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein from pregnancy hormone may prevent breast cancer
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... , , , , ... of the country returns from the Labor Day holiday, world-class speedskater Katherine ... she enters the US Olympic Short Track Speedskating Trials, in Marquette, MI. ... Olympic journey - officially earning a spot on the 2010 Olympic Team ...
... Sept. 8 /PRNewswire-FirstCall/ - (OTCBB: GVBP.OB) - GENova ... acquires, and develops novel drug targets that disrupt ... has appointed Dr. Anders Boegh Jensen to its ... will contribute his considerable expertise in biotechnology and ...
... the variation could help identify risk factors early on, researchers ... of a particular gene in people with cystic fibrosis greatly ... shows. , Cystic fibrosis is an inherited disorder that can ... 3 percent to 5 percent of the 30,000 people in ...
... symptoms stem from deficits in brain,s rewards system , ... that affects people with attention-deficit hyperactivity disorder (ADHD) might ... , The motivational problems seen with the condition, which ... adulthood, appear to stem from a reduction in dopamine, ...
... Ohio Hairstylists may have a unique opportunity to ... according to a small, exploratory study. More than ... older clients often or always shared their problems during ... to notice when their older clients are starting to ...
... , , HHS ... Model for Managing Childhood Asthma and Reducing H1N1 Risk , ... with asthma were welcomed along with other classmates back to school today ... healthy - Kathleen Sebelius, 21st Secretary of Health and Human Services (HHS). ...
Cached Medicine News:Health News:It's Now or Never - Deadline for Olympic-Hopeful Skater With Secret Weapon 2Health News:GENova appoints Dr. Anders Boegh Jensen to Scientific Advisory Board 2Health News:Gene Linked to Liver Disease in Cystic Fibrosis 2Health News:Motivation May Be at Root of ADHD 2Health News:Motivation May Be at Root of ADHD 3Health News:Study: Hairstylists can help identify older clients who need health services 2Health News:Study: Hairstylists can help identify older clients who need health services 3Health News:Children With Asthma More Vulnerable to H1N1 Virus 2Health News:Children With Asthma More Vulnerable to H1N1 Virus 3Health News:Children With Asthma More Vulnerable to H1N1 Virus 4
(Date:1/15/2014)... Mass. , Jan. 15, 2014  Zafgen, ... the unmet needs of severely obese patients, today ... of beloranib, a selective inhibitor of methionine aminopeptidase ... a severe form of genetic obesity.  These results ... body composition, including reductions in body fat content ...
(Date:1/14/2014)... BEVERLY HILLS, Calif. , Jan. 14, 2014 ... , offers Los Angeles a premier ... Duality laser and a $99 treatment special. Dr. Brandeis, focus ... medical technology and offering expert medical advice to all patients. ... a dramatic increase in the presence of tattoo regret and ...
(Date:1/14/2014)... 2014 NineSigma , Inc., the leading ... Innovation Leadership Summit , May 14-16, 2014 at the ... Ohio . This is the ... to breakthrough achievements through open innovation. Participants will learn ... across disciplines and even across industries. ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... WINDSOR, N.J. , July 7 ITelagen, a leading ... it was selected by Zweena, LLC of West Windsor, NJ ... ITelagen, which was selected for its expertise in EHR management, is ... solution. , , , ...
... DENVER , July 7 Invision Sally Jobe ... a new breast ultrasound technology for the early detection of cancer. Screening ... in women with radiologically dense breasts and other risk factors. , ... "Screening breast ultrasound is part ...
Cached Medicine Technology:Zweena Selects ITelagen to Host Personal Health Records Application 2Zweena Selects ITelagen to Host Personal Health Records Application 3Invision Sally Jobe Introduces New Breast Cancer Screening Technology to Denver 2Invision Sally Jobe Introduces New Breast Cancer Screening Technology to Denver 3Invision Sally Jobe Introduces New Breast Cancer Screening Technology to Denver 4
Fine pointed grooved jaws with smooth curve from tip to finger grip style handle. Dull finish....
Inner jaw space 2.0 mm - 45 degree tip angulation. 20 gauge (.89 mm) diameter shaft and stationary distal jaw. Lightweight squeeze handle with dull finish. Jaws 1.5 mm serrated....
Straight shafts with 5.5 mm tying platform and 45 degree 0.3 mm teeth. Wide serrated handle with polished finish....
Straight shafts with 1 x 2 teeth. Flat handle with polished finish....
Medicine Products: