Navigation Links
Protein from pregnancy hormone may prevent breast cancer
Date:11/24/2009

PHILADELPHIA Researchers have found that hormones produced during pregnancy induce a protein that directly inhibits the growth of breast cancer. This protein, alpha-fetoprotein (AFP), may serve as a viable, well-tolerated agent for the treatment and prevention of breast cancer, according to findings published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

"Hormones in pregnancy, such as estrogen, all induce AFP, which directly inhibits the growth of breast cancer," said lead researcher Herbert Jacobson, Ph.D., who is a basic breast cancer researcher in the Center for Immunology and Microbial Diseases and in the Department of Obstetrics, Gynecology and Reproductive Sciences at Albany Medical College, N.Y.

"The body has a natural defense system against breast cancer," he added. "AFP needs to be safely harnessed and developed into a drug that can be used to protect women from breast cancer."

Recent studies have shown that hormones released during pregnancy, such as estrogen, progesterone and human chorionic gonadotropin, reduce a women's risk for breast cancer. AFP is a protein normally produced by the liver and yolk sac of a fetus. Jacobson and colleagues sought to determine whether administering pregnancy hormones to carcinogen-exposed rats led them to produce AFP, which in turn produces the protective effect of pregnancy in the absence of pregnancy.

Results from this study showed that treatment with estrogen plus progesterone, estrogen alone or human chorionic gonadotropin reduced the incidence of mammary cancers in rats. Furthermore, the researchers noted that each of these treatments elevated the serum level of AFP and that AFP directly inhibited the growth of breast cancer cells growing in culture, suggesting that these hormones of pregnancy are preventing breast cancer through their induction of AFP.

Cancer Prevention Research Editorial Board Member Powel Brown, M.D., Ph.D., said while these preclinical findings are important and suggest a role of AFP in breast cancer prevention, they are not yet ready to be used in the clinic.

"The researchers have not directly demonstrated the cancer preventive activity of AFP, instead they found an association of these hormones preventing mammary tumors. None of these treatments prevented mammary tumors in 100 percent of the rats, it appears to delay mammary tumor formation and prevent breast cancer development in approximately 30 to 50 percent of the rats," said Brown, professor of medicine and cancer prevention and clinical cancer prevention department chairman at the University of Texas M. D. Anderson Cancer Center.

"This study is promising and suggests that additional animal studies need to be done before translation to humans," he said. "We may want to further test AFP for its cancer prevention activity."

Jacobson and colleagues are currently conducting studies in which they have isolated a small piece of AFP molecule and are working to convert it into a breast cancer preventative agent.


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein from pregnancy hormone may prevent breast cancer
(Date:2/22/2017)... ... February 22, 2017 , ... Bellus ... the latest innovation in the delivery of Platelet Rich Plasma (PRP). PRP systems ... pain management, to accelerate tissue synthesis and provide a faster and more efficient ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five percent of American respondents ... family members or friends have also commented about their poor hearing. However, only ... aids. One reason, suggested by 89 percent of American respondents, is that they ...
(Date:2/22/2017)... ... 22, 2017 , ... Pet obesity in the U.S. continued to steadily increase ... Association for Pet Obesity Prevention (APOP). During the ninth annual survey, APOP also found ... benefits of corn and grains, value of raw and organic diets, and the best ...
(Date:2/22/2017)... ... 22, 2017 , ... BrightStar Care Charleston , a home care and ... South Carolina (MUSC) Center on Aging’s Senior Expo on Thursday, March 23, 2017, ... a tremendous resource in our community. We are thrilled to participate in this event ...
(Date:2/22/2017)... ... February 22, 2017 , ... Alto-Shaam is pleased to announce ... Oven offers up to four ovens in one. Control temperature, fan speed and ... evenness in cooking. Alto-Shaam has partnered with Appliance Innovation to introduce this game-changing ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017 Summary Provides ... partnering deals and agreements entered into by the worlds ... http://www.reportlinker.com/p03605668-summary/view-report.html Description The Global Non-Small Cell Lung ... understanding and access to partnering deals and agreements entered ... - Trends in partnering deals - Top deals ...
(Date:2/22/2017)... Feb. 22, 2017  Corin Group announced today the ... used to treat patients with both a massive rotator ... The condition, known as cuff tear arthropathy, causes pain ... The Humelock Reversed Shoulder System, which was ... company based near Lyon, France , ...
(Date:2/22/2017)... Research and Markets has announced the ... 2016" report to their offering. ... Dermatological conditions are one ... one-third of the US population suffers from at least one ... the dermatology market has remained saturated with established and generic ...
Breaking Medicine Technology: