Navigation Links
Protein folding made easy
Date:6/7/2011

Protein folding has nothing to do with laundry. It is, in fact, one of the central questions in biochemistry. Protein folding is the continual and universal process whereby the long, coiled strings of amino acids that make up proteins in all living things fold into more complex three-dimensional structures. By understanding how proteins fold, and what structures they are likely to assume in their final form, researchers are then able to move closer to predicting their function.

This is important because incorrectly folded proteins in humans result in such devastating diseases as Alzheimer's, Parkinson's, Huntington's, emphysema and cystic fibrosis. Developing better modelling techniques for protein folding is crucial to creating more effective pharmaceutical treatments for these and other diseases.

Computational methods of modelling protein folding have existed for a couple of decades. But what McGill researcher Jrme Waldisphl of the McGill Centre for Bioinformatics has done, working with collaborators from MIT, is to develop algorithms that can work from a laptop computer to examine a protein's fundamental chemical properties and then scan a number of possible protein shapes before predicting the final form that the protein is likely to take.

The results have been impressive. Whereas classical techniques for predicting protein folding pathways required hundreds of thousands of CPU hours to compute the folding dynamics of 40 amino acids proteins, the program tFolder implemented by Solomon Shenker a former McGill under-graduate student now at Cornell has been able to predict correctly in 10 minutes on a single laptop, a coarse-grained representation of the folding pathways of a protein with 60 amino acids.

Waldisphl and his students continue to work on their algorithm to improve its success rate at predicting protein folding with broader categories of proteins including some that are important in DNA-binding. The research was recently presented at the 15th Annual International Conference in Research in Computational Molecular Biology (RECOMB 2011).


'/>"/>

Contact: Katherine Gombay
katherine.gombay@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert  

Related medicine news :

1. Beef: Americas favorite protein is an essential building block
2. Deadly bacteria may mimic human proteins to evolve antibiotic resistance
3. Protein drinks after exercise help maintain aging muscles
4. New protein linked to Alzheimers disease
5. NIH scientists identify most proteins made by parasitic worm
6. Heart scientists discover protein that may be 1 cause of heart failure
7. Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
8. Eat a protein-rich breakfast to reduce food cravings, prevent overeating later, researcher finds
9. Neutrons provide first sub-nanoscale snapshots of Huntingtons disease protein
10. Dynamics of crucial protein switch revealed
11. Cell rigidity linked to activity in proteins associated with cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein folding made easy
(Date:5/26/2016)... Fla. (PRWEB) , ... May 26, 2016 , ... The ... (AHEC) to host a six-week smoking cessation class starting June 6 at their clinic ... website, http://www.gnahec.org . , Additionally, the Lung Institute has created a free downloadable ...
(Date:5/26/2016)... ... ... The MIAMI Institute for Age Management and Intervention celebrates Global Wellness Day ... Dr. Adonis , Wellness Physician of the MIAMI Institute is certified by the American ... Medicine. , He also heads up FITTLab, the comprehensive medical testing lab located in ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... information to oncology professionals, has added National Cancer Institute-designated University of Virginia ... , In this new partnership, OncLive’s editorial and marketing teams will publicize and ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... organization to provide strategic sales leadership and to further develop their rapidly expanding ... B.S. in Business Administration with a concentration in Marketing and an M.B.A. with ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. LeRoy Perry’s recently authored whitepaper, ... mobile devices on the billions of users, hundreds of millions of whom are coming ... life threatening, the frequent and common action of looking down at hand-held technology devices ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... den Markt gebracht, die es Ärzten erlaubt, ihre ... zu behandeln: MDLinking kombiniert Live Streaming mit einer ... Umfeld zu kommunizieren. Mediziner in Europa, Afrika, Asien ... sich bereits für die Plattform registriert. ...
(Date:5/24/2016)...  Diana Russell suffers from a form of rheumatoid ... out.  This disease has put her in a wheelchair, ... grandchildren to leave her home.  Because of the size ... the wheelchair.  So if there is a family function, ... left to wait for the bus. Photo ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior vice ... officer, today. In his new role, Marziani will lead the company,s business development and ... to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: