Navigation Links
Protein folding made easy
Date:6/7/2011

Protein folding has nothing to do with laundry. It is, in fact, one of the central questions in biochemistry. Protein folding is the continual and universal process whereby the long, coiled strings of amino acids that make up proteins in all living things fold into more complex three-dimensional structures. By understanding how proteins fold, and what structures they are likely to assume in their final form, researchers are then able to move closer to predicting their function.

This is important because incorrectly folded proteins in humans result in such devastating diseases as Alzheimer's, Parkinson's, Huntington's, emphysema and cystic fibrosis. Developing better modelling techniques for protein folding is crucial to creating more effective pharmaceutical treatments for these and other diseases.

Computational methods of modelling protein folding have existed for a couple of decades. But what McGill researcher Jrme Waldisphl of the McGill Centre for Bioinformatics has done, working with collaborators from MIT, is to develop algorithms that can work from a laptop computer to examine a protein's fundamental chemical properties and then scan a number of possible protein shapes before predicting the final form that the protein is likely to take.

The results have been impressive. Whereas classical techniques for predicting protein folding pathways required hundreds of thousands of CPU hours to compute the folding dynamics of 40 amino acids proteins, the program tFolder implemented by Solomon Shenker a former McGill under-graduate student now at Cornell has been able to predict correctly in 10 minutes on a single laptop, a coarse-grained representation of the folding pathways of a protein with 60 amino acids.

Waldisphl and his students continue to work on their algorithm to improve its success rate at predicting protein folding with broader categories of proteins including some that are important in DNA-binding. The research was recently presented at the 15th Annual International Conference in Research in Computational Molecular Biology (RECOMB 2011).


'/>"/>

Contact: Katherine Gombay
katherine.gombay@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert  

Related medicine news :

1. Beef: Americas favorite protein is an essential building block
2. Deadly bacteria may mimic human proteins to evolve antibiotic resistance
3. Protein drinks after exercise help maintain aging muscles
4. New protein linked to Alzheimers disease
5. NIH scientists identify most proteins made by parasitic worm
6. Heart scientists discover protein that may be 1 cause of heart failure
7. Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
8. Eat a protein-rich breakfast to reduce food cravings, prevent overeating later, researcher finds
9. Neutrons provide first sub-nanoscale snapshots of Huntingtons disease protein
10. Dynamics of crucial protein switch revealed
11. Cell rigidity linked to activity in proteins associated with cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein folding made easy
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF Orthopaedic Center PA ... Area. The new location is located at 2255 E. Mossy Oaks Rd., Suite 440, ... newest location will provide patients living in the north Houston area (The Woodlands, Conroe, ...
(Date:3/23/2017)... , ... March 23, 2017 , ... The IoT (Internet ... WiFi connectivity are making a huge impact on businesses and individual consumers alike. ... the IoT will have a value anywhere from $4 trillion to $11 trillion dollars ...
(Date:3/23/2017)... ... March 23, 2017 , ... March is National Kidney Month – the perfect ... comes to maintaining good health. Every day, two kidneys filter about 120 to 150 ... of your blood, eliminating waste, regulating fluid levels and blood pressure, supporting bone health ...
(Date:3/23/2017)... Malvern, PA (PRWEB) , ... March 23, 2017 ... ... a comprehensive educational training program owned and organized by HMP Communications Holdings, LLC, ... training program for physicians within its nationwide network of wound centers interested in ...
(Date:3/23/2017)... ... March 23, 2017 , ... After raising more than $1.135 ... the most-funded travel pillow in crowdfunding history, has established a U.S. Headquarters ... popular travel innovation to Americans. , “We’re excited to be operating on U.S. shores, ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017  Ethicon* today announced ... Inc., a privately held medical device company that ... for the surgical treatment of Gastroesophageal Reflux Disease ... of expanding its portfolio of minimally invasive options ... conditions. Financial terms of the transaction have not ...
(Date:3/23/2017)... YORK , March 23, 2017 ... sample preparation market is expected to reach USD 7.2 billion ... of 7.1%. Sample preparation is a procedure in which a ... crucial step in most analytical procedures since the methods are ... preparation is one of the most shared procedures in the ...
(Date:3/23/2017)... 23, 2017  Drug diversion is a significant ... deadly overdoses. A new oral fluid monitoring test, ... , reports more detailed and actionable information to ... improve therapy adherence, patient safety, and help to ... Oral fluid Rx Evaluation (CORE) system is the ...
Breaking Medicine Technology: