Navigation Links
Protein discovered at LSUHSC may suppress breast cancer growth
Date:9/14/2011

New Orleans, LA Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, has found that a protein discovered by his laboratory can inhibit the growth of breast cancer cells. The research will be published September 14, 2011 online in the Journal of the National Cancer Institute.

Building upon Dr. Alahari's earlier discovery of Nischarin, a novel protein that regulates breast cancer cell migration and movement, this current study examines the presence and levels of Nischarin in breast cancer tumor tissue from 300 women as well as normal breast tissue samples. The researchers also generated derivatives of human metastatic breast cancer cells to test by manipulating the protein in a mouse model.

"We found that normal human breast tissue samples had statistically significantly higher levels of Nischarin compared with tumor tissue samples," notes Dr. Alahari, "and tumors grew significantly faster in the cells where we blocked the production of Nischarin. Tumor growth and metastasis were also reduced in the samples where we manipulated the overproduction of Nischarin. Our research shows that Nischarin can function as a tumor suppressor of breast cancer, inhibiting breast cancer progression."

The research team also describes the regulation of Nischarin and reports the genetic mechanism by which this protein suppressed breast tumor growth, information that could be used to target new treatment approaches.

Excluding skin cancer, breast cancer is the most common type of cancer among women in the United States. The National Cancer Institute estimates 230,480 new cases among American females this year, and 2,140 among men in the US, with 39,520 deaths in women and 450 deaths in men.

Risk factors include aging, weight gain, combined hormone therapy, physical inactivity, and consumption of one or mo
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. X-ray protein probe leads to potential anticancer tactic
2. Proteins could help women avoid thyroid surgery
3. Alzheimers brains found to have lower levels of key protein
4. Blood Protein Might Signal Death Risk in Elderly
5. Yale researchers use genetic code to engineer a living protein
6. Pitt cancer researchers find key oncoprotein in Merkel cell carcinoma
7. Basis for battery-powered skin patch for wider range of protein-based medicines
8. Researchers discover method to decrease harmful cyanogens and increase protein levels in key crop
9. Eliminating protein in specific brain cells blocks nicotine reward
10. Small Study Suggests Milk, Soy Proteins Lower Blood Pressure Modestly
11. NYU researchers develop compound to block signaling of cancer-causing protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The American Association for Physician Leadership® has named ... the 2015 winner of the Leape Ahead Award. The ... 18, in Las Vegas, Nevada. , “When health ... be dramatically improved,” said Peter Angood, MD, FRCS(C), FACS, ... its Academy for Quality and Safety should be commended ...
(Date:4/20/2015)... Western Connecticut Health Network (WCHN) ... FAAN who was named The Beatrice Hofstadter White ... September 2014, is transitioning from her current role ... development of Western Connecticut Health Network’s Nurse Leadership ... will be responsible for the identification and implementation ...
(Date:4/20/2015)... Early registration is open for the ... space at the start line. Returning to James Kealoha ... limited to 500 participants (actually there’s only 499 spots since ... , Now thru April 30, the entry fee is only ... May 1st, the fee goes up to $200 and $100, ...
(Date:4/20/2015)... 1% for the Planet , one of ... Kate Williams, the network’s Director of Partnerships, will step into ... has been part of 1% for the Planet since early ... the Northern Forest Canoe Trail, a 1% for the Planet ... stewardship of and advocacy for the outdoors, a commitment which ...
(Date:4/20/2015)... Alcohol-related incidents have been recognized as ... for decades. These result in billions of dollars ... damage each year, while inflicting an enormous emotional and ... families and loved ones. Throughout the year and each ... to raising awareness of alcohol addiction—its societal impact and ...
Breaking Medicine News(10 mins):Health News:2015 Leape Ahead Award honors Northwestern Medicine’s Academy for Quality and Safety Improvement 2Health News:2015 Leape Ahead Award honors Northwestern Medicine’s Academy for Quality and Safety Improvement 3Health News:Nursing Executive to Develop and Lead Nursing Leadership Program at Western Connecticut Health Network 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 3Health News:1% for the Planet Announces New CEO 2Health News:1% for the Planet Announces New CEO 3Health News:Drunk Driving Repeat Offenders: Suncoast Rehab Center Observes Alcohol Awareness Month by Advocating for Preventive Measures Against DUIs 2Health News:Drunk Driving Repeat Offenders: Suncoast Rehab Center Observes Alcohol Awareness Month by Advocating for Preventive Measures Against DUIs 3Health News:Drunk Driving Repeat Offenders: Suncoast Rehab Center Observes Alcohol Awareness Month by Advocating for Preventive Measures Against DUIs 4
... Sept. 4 Novo Nordisk, the,world,s leading diabetes ... president of Novo Nordisk Inc., the company,s U.S. ... America. Gruhn will replace,Martin Soeters, who will take ... overseeing the company,s operations in 35 countries. Gruhn,is ...
... Therap Services, the leading,provider of on-line applications ... Noonan and Kara Blevins as Customer,Support Specialists. The ... and training to Therap users. "We are ... our team. They bring,with them their wealth of ...
... Communications, an,innovator in health care communications and ... to promote its novel technology that uses,nano-sized ... normal,tissue. MedThink will implement a scientifically ... development and medical,communications in order to advance ...
... 2007 A study by UT Southwestern Medical Center researchers ... day care are at high risk for iron deficiency. ... toddlers, the study found that 20 percent of overweight toddlers ... for being overweight, and 7 percent of normal-weight toddlers. ...
... The American,Psychiatric Association (APA) applauds the U.S. Food ... that led to the,approval of a new treatment for ... that the approvals are a result of the federal,Best ... research that leads to this kind of approval, given ...
... molecule involved in many different cellular processes, plays a ... chronic physiological stress, resulting in increased susceptibility to illness. ... of the Proceedings of the National Academy of Sciences. ... National Space Biomedical Research Institute (NSBRI), the Busch Biomedical ...
Cached Medicine News:Health News:Novo Nordisk Appoints New Leader of North American Business 2Health News:Therap Services Continues to Hire Experienced Developmental Disability Industry Clinicians for its Customer Support Team 2Health News:MedThink Communications Retained by NanoBio Corporation 2Health News:Overweight toddlers and those not in day care at risk for iron deficiency 2Health News:Overweight toddlers and those not in day care at risk for iron deficiency 3Health News:APA Comments on FDA's First Approval of Medication to Treat Pediatric Schizophrenia and Bipolar Disorder 2Health News:Study identifies key player in the body's immune response to chronic stress 2Health News:Study identifies key player in the body's immune response to chronic stress 3
(Date:4/20/2015)... This report analyzes the worldwide markets for ADME-Toxicology Testing in ... In-Vitro), and ADME Testing. The report provides separate comprehensive analytics ... Japan , Europe , ... forecasts are provided for the period 2014 through 2020. Also, ... data and analytics are derived from primary and secondary research. ...
(Date:4/20/2015)... 20, 2015   Seahorse Bioscience , the ... introduces the XFp Cell Energy Phenotype Test Kit. ... live cells that determines their baseline metabolic phenotype ... mitochondrial and glycolytic activity of the cells, and ... stressed conditions, induced by a single injection, to ...
(Date:4/20/2015)... 2015  Sigma-Aldrich Corporation (Nasdaq: SIAL ) ... list of the 100 Best Corporate Citizens, which ... performance.  Sigma-Aldrich ranked fifth, its highest ranking to ... "We are honored to be recognized ... we are extremely pleased with our ranking," said ...
Breaking Medicine Technology:World ADME-Toxicology Testing Industry 2World ADME-Toxicology Testing Industry 3World ADME-Toxicology Testing Industry 4World ADME-Toxicology Testing Industry 5World ADME-Toxicology Testing Industry 6World ADME-Toxicology Testing Industry 7World ADME-Toxicology Testing Industry 8World ADME-Toxicology Testing Industry 9World ADME-Toxicology Testing Industry 10World ADME-Toxicology Testing Industry 11World ADME-Toxicology Testing Industry 12World ADME-Toxicology Testing Industry 13World ADME-Toxicology Testing Industry 14World ADME-Toxicology Testing Industry 15World ADME-Toxicology Testing Industry 16World ADME-Toxicology Testing Industry 17World ADME-Toxicology Testing Industry 18World ADME-Toxicology Testing Industry 19New XFp Cell Energy Phenotype Test Determines Metabolic Potential 2New XFp Cell Energy Phenotype Test Determines Metabolic Potential 3Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2
... Bionovo, Inc. (Nasdaq: BNVI ), a pharmaceutical ... effective treatments for women,s health and cancer, today announced the ... up to 30,031,200 units at a price per unit of ... unit consists of one share of common stock and a ...
... 2011 Surgical Information Systems ("SIS"), a ... that it has successfully completed the healthcare ... Healthcare Enterprise (IHE) Connectathon. (Logo: ... the healthcare IT industry,s largest interoperability testing ...
Cached Medicine Technology:Bionovo Announces Pricing of Follow-on Offering of Common Stock and Warrants 2Bionovo Announces Pricing of Follow-on Offering of Common Stock and Warrants 3Surgical Information Systems Completes IHE North American Connectathon 2
... Portex® Blue Line ULTRA® Suctionaid® tracheostomy tubes ... removal of secretions from above the tracheostomy ... ULTRA® Suctionaid® tracheostomy tubes provide an additional ... from above the tracheostomy tube cuff helping ...
Manufactured form the same soft siliconized PVC as all Portex® Blue Line® tracheostomy tubes....
... For additional patient safety, the ... an integral 15 mm ISO ... to a ventilator, with or ... place , ,Portex® laryngectomy ...
... When the all silicone cuff ... no distinguishable dimension to the ... shaft, yet it can be ... varied airway management needs. TTS™ ...
Medicine Products: