Navigation Links
Protein disables p53, drives breast cells toward cancer transition
Date:12/15/2010

that these structural domains suggest that TRIM24 not only can read the histone code but is actually reading a very unusual alphabet spelling of the histone barcode. This unusual histone signature appears at estrogen-response elements-places in the DNA where estrogen receptors bind - and it is regulating estrogen-regulated genes that become overstimulated by TRIM24. These genes push cells into proliferation and probably into tumorigenesis.

Overexpressed TRIM24 cuts survival

When the researchers examined a number of breast cancer cell lines, they found that TRIM24 was overexpressed in each one. "Because TRIM24 is basically undetectable in normal cells," Barton said, "we believe that by virtue of its being overexpressed, it's negatively regulating p53 and overstimulating estrogen receptors that, in turn, promote the proliferation."

Collaboration with MD Anderson's Mien-Chie Hung, Ph.D., chair of the Department of Molecular and Cellular Oncology, further strengthened the case for TRIM24's role in breast cell proliferation and tumorigenesis. When pathologist Weiya Xia, M.D., screened biopsies of 128 breast cancer patients, she found that TRIM24 was overexpressed in 70 percent. These patients had a median overall survival rate of 50 months, meaning half of them survived at least to that point.

In 30 percent of the women, TRIM24 was either undetectable or expressed at very low levels. In these two groups, the women's breast cancer was non-metastatic, and 90 percent survived to 50 months.

Avenues of future research

"We propose that TRIM24 would be a great therapeutic target - the reason being that if you were to eliminate or inactivate TRIM24, you could potentially restart p53 function and decrease estrogen receptor function in breast tumor cells," Barton said. "In the case of ER-negative tumors, you might still have a chance to go for the p53, and in the case of breast cancers that are p53-negative you might stil
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Protein offers new clue to cause and treatment for kidney disease
2. Protein targeted to stop melanoma tumor growth
3. New Test Links Blood Protein to Heart Disease, Diabetes Risk
4. Scientists Find Protein That May Help Control Prostate Cancer
5. Neurological protein may hold the key to new treatments for depression
6. More Protein, Fewer Refined Carbs May Keep Weight Off
7. Protein found to predict brain injury in children on ECMO life support
8. Protein in the urine: A warning sign for cognitive decline
9. Scripps Research scientists identify first synthetic activator of 2 critical proteins
10. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
11. Protein Differences May Explain Long-Term HIV Control
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein disables p53, drives breast cells toward cancer transition
(Date:7/30/2015)... ... July 30, 2015 , ... 24/7 Care At Home, a high-quality ... Bernardino, recently announced that the Centers for Medicare and Medicaid (CMS) have awarded its ... care providers. 24/7 Care At Home’s agency is one of three top Orange County ...
(Date:7/30/2015)... ... ... The need for accessibility is never greater than when we find ourselves ... as visiting friends and family during these critical moments, hospitals around the Pennsylvania region ... by ChargeItSpot , a Philadelphia-based startup that recently secured a $4M Series A ...
(Date:7/30/2015)... ... July 30, 2015 , ... OncLive®’s ... and UCLA’s Jonsson Comprehensive Cancer Center (JCCC) mutually agreed to collaborate ... collaboration, OncLive’s editorial and marketing groups will help spread the news about the ...
(Date:7/30/2015)... ... July 30, 2015 , ... Zejax is ... Tool That Increases Training Capability , World renown body weight trainer, Paul ... http://www.Zejax.com ), that dramatically increases a person’s training capability. , The American College ...
(Date:7/30/2015)... California (PRWEB) , ... July 30, 2015 , ... ... services, announced today that the latest issue of Inclusive™ magazine, its multimedia publication ... platforms. The digital edition of the new issue, Volume 6, Issue 2, as ...
Breaking Medicine News(10 mins):Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2Health News:Hospitals Add Phone Charging Stations as an Amenity for Patients and Visitors 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 4Health News:Zejax is a Revolutionary New Way of BodyWeight Training Without Weights 2Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 2Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 3Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 4
... Benefit from Fosamax, Boniva, Zometa does not apply to obese ... types of bone-building drugs used to prevent and treat osteoporosis ... research. , The study, which included 6,000 Wisconsin women aged ... such as Fosamax, Boniva and Zometa for more than two ...
... ... wireless fitness sector. , ... Cochrane, Alberta (PRWEB) March 5, 2010 -- ANT Wireless ("ANT" www.thisisant.com ), ... ANT+ Alliance. A noted leader in the design and manufacturing of sport ...
... Twelve children ... attorneys like David Perecman understand frustration of the families. , ... New York, NY (PRWEB) March 5, 2010 -- The U.S. ... by Maclaren. However, as reported by the New York Post , this was ...
... ... partnership with leading SolidWorks and Agile PLM reseller GoEngineer to distribute DesignState Enterprise PDM ... to manage engineering data and collaborate across the enterprise with Oracle,s powerful Agile ... ...
... ... in the U.S., according to the Centers for Disease Control (CDC). , ... Charleston, SC (PRWEB) March 5, ... Infections (HAIs) and they have generated much attention over the last decade. Studies have ...
... ... Mikel J. Harry, the world renowned co-creator of Six Sigma and national ... achievement to the point of breakthrough – and beyond. In this ... can envision, plan and achieve extraordinary things. The Great Discovery® is a ...
Cached Medicine News:Health News:Certain Bone Drugs May Lower Breast Cancer Risk 2Health News:Suunto Joins ANT+ Interoperable Ecosystem 2Health News:Suunto Joins ANT+ Interoperable Ecosystem 3Health News:Defective Child Product Recall Involves New York Personal Injury Attorneys 2Health News:Enterprise PDM Integration has Never Been Easier; Zero Wait-State Announces Leading SolidWorks Reseller GoEngineer as Master Distributor for DesignState 2Health News:Enterprise PDM Integration has Never Been Easier; Zero Wait-State Announces Leading SolidWorks Reseller GoEngineer as Master Distributor for DesignState 3Health News:24x7 Infection Control, Inc. Announces World's First, Modern “Shield” Against Microbial Contamination 2Health News:24x7 Infection Control, Inc. Announces World's First, Modern “Shield” Against Microbial Contamination 3Health News:Co-Creator of Six Sigma Unveils “The Great Discovery” ... the 4th Generation of Six Sigma 2
(Date:7/30/2015)... SAN DIEGO , July 30, 2015 ... announced it has signed a definitive agreement ... provider of non-invasive ventilation and sleep-disordered breathing ... strong clinical, innovation and market reputation in China, combined with ResMed,s global leadership ... of people in China ...
(Date:7/30/2015)... 2015  EP Global Communications, Inc. (Public OTC: EPGL) announced ... the Company about discussing EPGL,s electronic contact lens ... August 3, 2015.  Novartis CEO Joe Jimenez ... coming electronic contact lens market could be worth ... several years.  Novartis partnered with Google in 2014 ...
(Date:7/30/2015)... 30, 2015  Amgen (NASDAQ: AMGN ) ... of 2015. Key results include: , Total ... of 2014 to $5,370 million, with 6 percent ... (etanercept), Prolia ® (denosumab), Sensipar ® ... ® (denosumab). Unfavorable changes in foreign exchange ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23
... Calif., Feb. 25, 2011 Accuray Incorporated ... the field of radiosurgery, announced today that its Senior Vice ... was named "Best General Counsel, Small Public Company" by the ... San Francisco Business Times as part of their ,Best ...
... Landauer, Inc. (NYSE: LDR ) announced today that ... $0.55 per share for the second quarter of fiscal 2011.  The ... record on March 11, 2011. About Landauer ... analytical services to determine occupational and environmental radiation exposure and is ...
Cached Medicine Technology:Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 2Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 3Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 4
... the use of plates and screws in the treatment ... pins in the forearm or ankle is not a ... lock the pins or hold them in place. A ... out of the implant. The SST® (Stainless Steel Taper) ...
... 36 cc and 73 grams, the Epic ... care and simplified follow-up. The Epic HF ... 30 joule (delivered energy) biventricular ICD. Small ... HF ICD features advanced resynchronization parameters along ...
... has greatly enhanced the stabilization ... Biomet Low Profile Tibial Nail ... treatment of unstable fractures, tibial ... pathologic or impending fractures but ...
The Charlotte Shoulder™ System address arthroscopic, mini-open and open procedures with time saving instrumentation....
Medicine Products: