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Protein-dependent 'switch' regulates intracellular trafficking in epithelial cells
Date:12/11/2007

ts out.

But how does the mature cell decide which kinesin to put to work on a particular transport mechanism"

"Right now, we just don't know," Dr. Kreitzer said. "Figuring out that molecular 'switch' is the next great frontier in this research."

For now, the study's findings hold promise for the study of devastating illnesses caused by defective placement of surface proteins, such as in cystic fibrosis, and even cancer.

"Right now, most chemotherapy targets the whole microtubule 'track' -- that's a really heavy-handed approach that typically affects the cell as a whole and causes serious side effects," notes Dr. Kreitzer.

"Imagine, though, that we could use what we now know about kinesins to target only the specific trafficking machinery that's gone awry," she says. "The result could be better, safer cancer care. And that paradigm holds true for a myriad of other diseases, as well."


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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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