Navigation Links
Protein-dependent 'switch' regulates intracellular trafficking in epithelial cells
Date:12/11/2007

NEW YORK (Dec. 10, 2007) -- With findings highlighted on a recent cover of Developmental Cell, researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs.

Specifically, the team has discovered a molecular "switch" in developed epithelial cells that selects from a large family of "motor proteins," called kinesins. Each kinesin facilitates the transport of specific surface markers from production sites inside the cell to their ultimate home on the cell's surface.

"Not only are many more kinesins present in cells than previously thought, but their selectivity helps direct which packages of surface proteins are transported, as well as their ultimate destinations," explains lead researcher Dr. Geri Kreitzer, assistant professor in the department of cell and developmental biology at Weill Cornell Medical College.

"Breakdown in these types of intracellular trafficking pathways is a serious contributing factor to many diseases ranging from cystic fibrosis to cancer," Dr. Kreitzer continues. "So, a better understanding of processes directed by the specific kinesin family members marks a big step forward in developing therapeutics that might someday treat or cure these illnesses. By targeting the individual motors rather than the tracks along which they all move (a current approach used to treat some types of cancer), we could bypass some of the effects on global cellular function that affect patients adversely."

Scientists have long understood the importance of kinesins in the life of the cell, she notes.

"These proteins are essentially 'trains' pulling packets (vesicles) of essential proteins and lipids from production sites in the heart of the cell up to areas on the outer surface, where the cell interacts with its environment," Dr. Kreitzer explains.

These kinesin "trai
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Schizophrenia Gene May Have On/Off Switch
2. Brain Switch Helps Doctors Deal With Patients Pain
3. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
4. Scientists Spot Eye Development Switch
5. A molecular switch is linked to a common breast cancer
6. Researchers identify unusual molecular switch for common form of advanced breast cancer
7. Cell Structure Helps Direct Cancer Gene Switch
8. Childrens Hospital researchers identify molecular switch that could save very young lives
9. Human C-reactive protein regulates myeloma tumor cell growth and survival
10. Insulin regulates the secretion of the antiaging hormome Klotho
11. New developments in biomarkers for epithelial ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Riverside Health System became the first provider of ... 2012 and now, in partnership with Williamsburg Landing, will offer ... and Newport News region. , Also known as life care ... older adults who wish to remain in their homes but ... care services as well as control over the cost of ...
(Date:7/11/2014)... Pigments are insoluble colorants, which usually consist of ... coating, opacity, and coloring. These are water and oil ... substances such as paper, paints, plastics, and concrete. Binders ... impart color to the substance. Some examples of pigments ... , The coloring action of pigments is due to ...
(Date:7/11/2014)... Riviera Maya, Mexico (PRWEB) July 11, 2014 ... Mexico with the Mayan Heritage Experience Package at the ... Highlights of the package include a guided on-site ecological ... fauna, as well as The Coba Mayan Encounter Tour ... also climb Nohoch Muul, the tallest pyramid in the ...
(Date:7/11/2014)... Recently, Fadhits.com, the distinguished wedding dress manufacturer ... prom dresses . To bring more benefits to worldwide clients ... a special offer for these brand new items. Clients can ... company’s sales manager says gladly, “We are happy to announce ... to acknowledge all new and old customers and strengthen our ...
(Date:7/11/2014)... that people who have grown up on a farm ... urban counterparts to develop the most common inflammatory bowel ... have recently been published in the European Journal ... we can now see that not only allergic diseases, ... on the environment we are exposed to early in ...
Breaking Medicine News(10 mins):Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 2Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 3Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 3Health News:Promotion for Kids Prom Dresses Now Provided at Fadhits.com 2Health News:Growing up on a livestock farm halves the risk of inflammatory bowel diseases 2
... use of complementary and alternative medicine (CAM) in over 2000 ... from acupuncture to yoga - has increased in popularity since ... medicine has always been popular, although the type of therapies ... ,The greatest increase in popularity was in the transition ...
... found a cheap and non toxic method of treating Hepatitis, ... virus infects the liver, and in severe cases can lead ... through contact with the blood or body fluids of an ... HBV after a very bright and aware patient observed that ...
... gives powerful relief for chronic pain, and should be ... told a conference in Glasgow.,Dr William Notcutt of the ... cannabis extract used in his study - applied as ... in easing chronic pain. He announced the findings at ...
... Both drugs and surgery may be effective in treating Meniere's ... the hearing apparatus. A build up of pressure causes vertigo ... leads to hearing loss in the affected ear, and the ... ,This disease has a wide range of treatments available.Many ...
... form of arterial disease appear to have low levels of ... smoking habits. ,Peripheral artery disease (PAD) is a form of ... arteries and obstructs blood flow. In PAD, blood flow in ... and pain. PAD is also associated with an increased risk ...
... the number of miles you fly affects your risk of ... increase the risk of blood clotting in the veins of ... breaks off, it may travel to the lungs, forming a ... ,Researchers in France and the US have monitored all ...
Cached Medicine News:
(Date:7/10/2014)... , July 10, 2014 CVS Caremark Corporation ... of directors has approved a quarterly dividend of $0.275 (27.5 ... is payable on August 1, 2014, to holders of record ... CVS Caremark is dedicated to helping people on ... company in the United States . Through ...
(Date:1/15/2014)...  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the ... Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... in order to treat dental impairments, for tooth restoration ...
(Date:1/15/2014)... 2014 Massachusetts General Hospital (MGH), the Broad ... announced today that they have launched a strategic ... targets and develop novel therapies for inflammatory bowel ... worldwide. The MGH-Broad-Amgen collaboration brings together scientists with ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... , , JERUSALEM , ... Dr. Amatruda is the Former Senior Vice President and Franchise Head of,the ... Oramed Pharmaceuticals, Inc. (OTCBB: ORMP.OB; http://www.oramed.com ), a,developer of oral ... Oramed,s Scientific Advisory Board, enhancing Oramed,s,talented and experienced scientific team. , ...
... , , MOUNTAIN VIEW, Calif. ... ) announced today that it will host an investor/analyst meeting on ... ET , in New York City . , The meeting will ... CEO, Alexza Pharmaceuticals James Cassella , PhD - ...
Cached Medicine Technology:Oramed Pharmaceuticals Expands Scientific Advisory Board With the Appointment of John Amatruda, M.D. 2Oramed Pharmaceuticals Expands Scientific Advisory Board With the Appointment of John Amatruda, M.D. 3Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010 2Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010 3Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010 4
Double-ended. Blunt and semi sharp 5 mm tips. Designated most popular model or size....
Double-ended. Designated most popular model or size....
Designated most popular model or size. Double-ended. 2 mm wide....
Desmarres Retractor Size 4...
Medicine Products: