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Protein critical for insulin secretion may be contributor to diabetes
Date:10/26/2009

, a girl diagnosed with Type 1 diabetes that was treated by Philipson and University of Chicago Medical Center colleagues in 2006. Lilly was found to have a rare genetic mutation in a different cellular protein, meaning her disease was treatable with oral medication rather than insulin injections.

A mutation of the ClC-3 channel would probably still be treated with insulin rather than an oral medication. But observing ClC-3 function in humans may provide insight into Type 2 diabetes as well, Philipson said, as the disruption of insulin production and secretion resembles cellular effects seen in adult-onset diabetes.

"We know that Type 2 diabetes is a progressive illness where insulin secretion is high and then goes down over time, but why does it do that? This ties some connection between chloride channels and granular function to the ability of insulin to come out of the cell," Philipson said. "This could be an important pathway in Type 2 diabetes, so it's not just the rare patient that's affected, it's 25 million people in the United States."


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Contact: Rob Mitchum
robert.mitchum@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

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