Navigation Links
Protein could be used to treat alcohol effects on pancreas
Date:3/22/2011

A Cardiff University-led study has discovered that a protein provides protection against the effects of alcohol in the pancreas.

The findings of the study, funded by the Medical Research Council, could lead to the development of new treatments to reduce the chances of people developing pancreatic cancer.

The protein, calmodulin, is involved in the basic processes that take place in all cells, the building blocks of the body. This study reveals that when calmodulin is missing from cells in the pancreas, alcohol has a much greater toxic effect as a chain reaction which causes cells to self destruct speeds up. This can lead to inflammation (pancreatitis), which in the long-term significantly increases the risk of developing pancreatic cancer. Pancreatic cancer is the fifth most common cause of death through cancer, and only three per cent of patients survive beyond five years.

The study team, led by Professor Ole Petersen in the MRC Group at Cardiff University's School of Biosciences, found that calmodulin protects pancreatic cells against alcohol's toxic effects when it is activated by another small protein, CALP-3.

Professor Petersen said: "There is still much uncertainty about how alcohol damages cells in the body. However, we have found a new and unexpected way that pancreatic cells protect themselves. We suggest that activation of the calmodulin protein protects against the development of pancreatitis. There is a strong correlation between alcohol intake and incidence of pancreatitis, and we hope that our new findings will eventually lead to the development of drugs to combat this. This is a key step forward."

Professor John Iredale, Head of the University of Edinburgh/MRC Centre for Inflammation Research, remarked: "This is a really important finding. Acute pancreatitis, which is currently untreatable, remains an important cause of death. It is important also to recognise that this disabling disease may result from binge drinking. The MRC is committed to understanding inflammation especially in examples with serious implications like this. We focus on driving the translation of discoveries from basic science into benefits for human health."


'/>"/>

Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... ... ... Goodcents Deli Fresh Subs announced a franchise expansion agreement today including three ... The first new location will open at the corner of 27th and Randolph in ... Drive this fall. And the third location is in the process of being identified. ...
(Date:4/27/2017)... ... April 27, 2017 , ... Are you investing in the ... water-related accidents and drownings during the summer. While most of us assume this type ... occur every day. Very few people are taking the time to learn how to ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... management in hospitals, today announced it has completed a round of funding to ... LLC and its partners. Black Granite Capital is a growth equity firm focused ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... Journal ... adults. It can have severe consequences to overall dental health, including complications with speech, ... often turn to dental implants to replace lost teeth. As the number of tooth ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... the adoption of e-prescribing as measured in Part D Medicare data. The dataset, ... to pharmacies, either using e-prescribing, faxes or paper. The PaPR (pronounced "paper") ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Research and Markets has announced the addition ... Addressing Production Complexities Through Risk Management and Quality by ... ... Market Prospects: Overcoming Production Complexities Through Risk Management and ... current trends in the global biosimilars market, with a ...
(Date:4/20/2017)... -- Research and Markets has announced the addition of ... Expanding Injectables Market and Increasing Usage of Complex Biologics during the ... ... from USD 20 Billion in 2015 to around USD 26 Billion ... Innovation Driven by Rapidly Expanding Injectables Market and Increasing Usage of ...
(Date:4/20/2017)... Inc ., a digital health company focused on modernizing and ... $25 million in Series B funding led by Qiming US ... Seattle that is part of a broader family ... included participation from SR One , who led ZappRx,s ... Google Ventures). As part of the financing, Mark McDade ...
Breaking Medicine Technology: