Navigation Links
Protein could be used to treat alcohol effects on pancreas
Date:3/22/2011

A Cardiff University-led study has discovered that a protein provides protection against the effects of alcohol in the pancreas.

The findings of the study, funded by the Medical Research Council, could lead to the development of new treatments to reduce the chances of people developing pancreatic cancer.

The protein, calmodulin, is involved in the basic processes that take place in all cells, the building blocks of the body. This study reveals that when calmodulin is missing from cells in the pancreas, alcohol has a much greater toxic effect as a chain reaction which causes cells to self destruct speeds up. This can lead to inflammation (pancreatitis), which in the long-term significantly increases the risk of developing pancreatic cancer. Pancreatic cancer is the fifth most common cause of death through cancer, and only three per cent of patients survive beyond five years.

The study team, led by Professor Ole Petersen in the MRC Group at Cardiff University's School of Biosciences, found that calmodulin protects pancreatic cells against alcohol's toxic effects when it is activated by another small protein, CALP-3.

Professor Petersen said: "There is still much uncertainty about how alcohol damages cells in the body. However, we have found a new and unexpected way that pancreatic cells protect themselves. We suggest that activation of the calmodulin protein protects against the development of pancreatitis. There is a strong correlation between alcohol intake and incidence of pancreatitis, and we hope that our new findings will eventually lead to the development of drugs to combat this. This is a key step forward."

Professor John Iredale, Head of the University of Edinburgh/MRC Centre for Inflammation Research, remarked: "This is a really important finding. Acute pancreatitis, which is currently untreatable, remains an important cause of death. It is important also to recognise that this disabling disease may result f
'/>"/>

Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Red Bank, NJ (PRWEB) September 19, 2014 ... Jersey’s largest not-for-profit provider of home health care, hospice ... join Deutsche Bank to ring the Opening Bell yesterday ... 1912 by a New Jersey philanthropist and social entrepreneur ... other diseases, VNA Health Group has always worked to ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Boston Scientific ... mesh lawsuit ( http://www.transvaginalmeshlawsuithelp.com/ ) that is scheduled ... month, Bernstein Liebhard LLP reports. According to ... Court, the company asserts that claims involving its Solyx ... Practice and Remedies Code, a section of which shields ...
(Date:9/19/2014)... Sept. 19, 2014 (HealthDay News) -- Your brain structure could ... a new study suggests. Researchers at Yale University found ... known as the parietal cortex may be more likely to ... this area. , , The study, funded by the U.S. ... men and women living in the Northeast. The researchers sought ...
(Date:9/19/2014)... News) -- Although there is mounting evidence that ... and older adults in the United States don,t ... new research. Less than one-quarter of adults ... the Department of Health and Human Services, the ... promoting health and fitness and staying independent, researchers ...
(Date:9/19/2014)... HealthDay Reporter THURSDAY, ... by stress and family conflicts before surgery may face ... new study suggests. Investigators found that patients with ... three times greater risk for complications compared to those ... "We,ve long known that patient quality of life is ...
Breaking Medicine News(10 mins):Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3Health News:Transvaginal Mesh Lawsuit Defendant Moves For Summary Judgment in Case Scheduled for Upcoming Texas Trial, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit Defendant Moves For Summary Judgment in Case Scheduled for Upcoming Texas Trial, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuit Defendant Moves For Summary Judgment in Case Scheduled for Upcoming Texas Trial, Bernstein Liebhard LLP Reports 4Health News:Brain Structure Might Help Predict Risky Behavior 2Health News:Adults Over 45 Not Meeting U.S. Muscle Strengthening Guidelines, Study Says 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 3
... that food rich in carbohydrates was very effective in maintaining ... are to be presented at the Australian //Institute of Food ... study was conducted by the University of Melbourne research dietician ... obese people for a period of 12 weeks. ...
... 2 diabetes over a period of 22 years have revealed ... This has helped to highlight the need ... Dr. Mohsen Janghorbani from Isfahan University of Medical Sciences in ... a consequence of diabetes mellitus. However, this study, as well ...
... research has revealed that men and women often respond differently ... gene behavior in the organs of males and females//. ... humans, have been used as the subjects of the study ... tissue. The results of the research have been published in ...
... treating patients with mouth and throat cancer with ‘Manuka honey’, ... at the Manchester cancer hospital explained that the honey is ... Hospital in Didsbury, Manchester, are planning to use it on ... They hope to try and reduce the patient’s chances of ...
... Dr. P. Venugopal won a reprieve on Friday when ... Institute's Governing Body recommending his sacking.// ,'The decision ... Venugopal's services, is stayed and the government is restrained ... Kumar said in his order. ,He issued ...
... to introduce new legislation to regulate doctors, due to be ... seeking Government approval in order to publish heads of bill ... that a new Medical Practitioners Bill can be published later ... Act have been promised and postponed for many years, it ...
Cached Medicine News:Health News:Diabetic Women Show Increased Risks of Hip Fracture 2
(Date:9/19/2014)... , Sept. 19, 2014  CytRx Corporation (Nasdaq: ... specializing in oncology, today announced that David J. ... BioCentury,s 2014 NewsMakers in the Biotech Industry Conference on Friday, ... The conference will take place at the Millennium Broadway ... A live and archived webcast of the ...
(Date:9/19/2014)... -- Reductions in kidney failure obtained during ... with diabetes type 2 "Intensive treatment is ... kidneys." Australian researchers have discovered that intensive ... to persistent reductions in kidney failure many years after ... has found that, five and a half years after ...
(Date:9/18/2014)... September 19, 2014 ... http://www.researchandmarkets.com/research/qqjrnh/global_molecular ) has announced the addition of ... report to their offering. ... the study of chromosomes using molecular biology ... genes and chromosomes. It plays a crucial ...
Breaking Medicine Technology:CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 2CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 3ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3Global Molecular Cytogenetics Market 2014-2018: Key Vendors are Abbott, Affymetrix, Agilent Technologies, F. Hoffmann-La Roche, Illumina and PerkinElmer 2Global Molecular Cytogenetics Market 2014-2018: Key Vendors are Abbott, Affymetrix, Agilent Technologies, F. Hoffmann-La Roche, Illumina and PerkinElmer 3
... /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. (NYSE AMEX: ... "Company"), a developer, manufacturer and distributor of botanical ... China, today announced that the Company,s Badger Oil, ... Pharmaceutical Co., Ltd ("Renhuang"), has achieved sales of ...
... Alison MacNeil issued the following statements today regarding ... PBS this week: "When I vaccinated ... are not required to test the safety of vaccines ... thousands of parents with Autistic children report that, like ...
Cached Medicine Technology:China Botanic Pharmaceutical Provides Update on Badger Oil Sales 2China Botanic Pharmaceutical Provides Update on Badger Oil Sales 3Daughter of Journalist Robert MacNeil States that Son Regressed Into Autism After Vaccines 2
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
... Indirect Ophthalmoscope Power Source provides power to ... ophthalmic instruments. The versatile wall/desk power source ... or on the side of a desk ... portable power pack provides power no matter ...
The Welch Allyn 125 BIO is designed to achieve precise binocular viewing and stereopsis easier than ever before. Its observation paths can be adjusted from 48 mm to 74 mm to handle the widest and nar...
Medicine Products: