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Protein complex linked to cancer growth may also help fight tumors, Moffitt researchers say
Date:7/22/2013

filtration in lung cancer," explained study co-author Dung-Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt. "Multiple genes, capable of enhancing T-cell responses, were found in the NF-κB signature. This means that NF-κB, thought of as a tumor promoter, also helps facilitate an immune response."

Their finding that the presence of high levels of NF-κB in lung cancer tumors can act as a suppressor provides new insight into how tumor pathways regulate the anti-tumor response.

"T-cell presence in tumors can be associated with immune surveillance and improved patient survival," explained Beg. "The focus of immune therapy, boosting T cell-induced responses against solid tumors, has shown considerable promise. However, tolerance-inducing mechanisms and the presence of suppressive cell types in the tumor microenvironment can dampen the response to immunotherapy. Our findings provide new insights into beneficial pathways that also operate in tumors and can regulate anti-tumor responses."


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Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

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