Navigation Links
Protein compels ovarian cancer cells to cannibalize themselves
Date:11/14/2008

to inhibit cancer in two distinct ways depending on its location in the cell.

First, PEA-15 inhibits one of the prominent actors in the growth, differentiation and mobility of cells, a protein called extracellular signaling related kinase, or ERK. Activated ERK in the cell nucleus fuels cancer growth. The research team earlier found that PEA-15 binds to ERK in the nucleus and moves it out into the cytoplasm, preventing its growth effects.

Now they've found that PEA-15 in the cytoplasm induces autophagy in cancer cells, a second method of inhibiting cancer growth. "These two very different actions by PEA-15 are based on the location of the protein," Ueno said.

ERK is an inviting target for cancer therapy, Ueno noted, but so far no one has been able to develop a successful ERK inhibitor.

"PEA-15 offers us a new dimension for potentially targeting ERK," Ueno said. "We've shown with high levels of PEA-15, women with ovarian cancer are surviving longer." Levels of the protein in tumors also might affect how other drugs work against the disease. Similar research is under way in breast cancer with. PEA-15, which is short for phospho-enriched protein in astrocytes.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Lipoprotein Levels May Predict Womens Hypertension Risk
2. New laser method reproduces art masterworks to protein patterns
3. Protein can nurture or devastate brain cells, depending on its friends, researchers find
4. Statin Reduces Heart Attack, Stroke Rates in Patients With Normal Cholesterol but Elevated C-Reactive Protein
5. Omega Protein Reports 17 Cents Per Share Third Quarter Profit
6. Signaling between protein, growth factor is critical for coordinated cell migration
7. Quintet of proteins forms new, early-warning blood test before heart attack strikes
8. Cell Biosciences Introduces First Protein Analysis Kits
9. The Wellness(R) Core(R) Family Continues to Grow With New Higher Protein, Grain-Free Canned Varieties for Cats and Dogs
10. Key Blood Test Protein May Not Cause Heart Disease
11. Elaborate Network Drives When and Where Proteins Are Made
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... MO (PRWEB) May 21, 2013 The ... news for women who have used the contraceptive NuvaRing. ... lawsuits alleging blood clot injuries has increased in recent ... popular prescription drugs and devices with the latest safety ... out if others are experiencing similar side effects and ...
(Date:5/20/2013)... was significantly associated with higher hyperactivity scores at ... University of Cincinnati (UC) and Cincinnati Children,s Hospital ... a study being published Tuesday, May 21, in ... access journal published by the National Institute of ... Institutes of Health (NIH). , The research ...
(Date:5/20/2013)... Minneapolis, MN (PRWEB) May 20, 2013 When ... right bed is only part of the process. Much of ... over the internet involves not knowing what to expect. ... expert advice consumers can use to ensure their purchase proves ... When You Buy a Mattress Online ”, readers find helpful ...
(Date:5/20/2013)... Dr. Robert Mokbel is one of the ... the Laser Assisted New Attachment Procedure, a laser ... disease. LANAP may help many Fountain Valley residents who ... the jawbone support necessary to support dental implants. , ... tartar in the mouth. Daily oral hygiene activities typically ...
(Date:5/20/2013)... York, NY (PRWEB) May 20, 2013 ... protecting the rights of victims injured by defective drugs, ... Dakota man who alleges that use of the diabetes ... The suit was filed on April 30, 2013, in ... Louisiana (Case No. 6:13-cv-0888), where it is one of ...
Breaking Medicine News(10 mins):Health News:DrugRisk Update Shows Increase in NuvaRing Blood Clot Lawsuits 2Health News:Early-life traffic-related air pollution exposure linked to hyperactivity 2Health News:See What to Expect When You Buy a Mattress Online With Latest Guide From Best Mattress Online 2Health News:Fountain Valley, Ca Gum Disease Patients with Missing Teeth Can Now Receive Laser Gum Surgery from Dr. Robert Mokbel for Success with Dental Implants 2Health News:Taking Actos for Two Years Caused Bladder Cancer, Alleges Lawsuit Filed by Parker Waichman LLP on Behalf of South Dakota Man 2
... incidence of ,food insecurity, , , TUESDAY, Nov. 4 (HealthDay News) ... to be underfed and undernourished, a new study finds. , ... but children feel the impact the most, said study author ... School of Medicine. , "We know that there are long-term ...
... Vericept, the leading provider,of data loss prevention ... announce the achievement of a significant milestone ... healthcare industry have selected,Vericept,s DLP solution to ... well as safeguard patient data and other ...
... 4 Jennerex, Inc. (San Francisco, CA,and Ottawa, Canada) ... M.D., President and Chief Executive Officer,will present an overview ... Renshaw,Healthcare Conference in New York on November 11, 2008 ... the Palace Hotel, New York., A webcast of ...
... adds 400,000 members and brings Blue branded dental ... Pa., Nov. 4 Capital BlueCross announced,today that ... held,corporation headquartered in Alexandria, VA. The move by ... throughout the,Commonwealth of Pennsylvania and the Mid-Atlantic Region., ...
... sonography or ultrasound to visualise organs and other internal ... has developed a computer model that can predict the ... computer model is capable of processing large quantities of ... and a parallel supercomputer. Erasmus University Medical Centre and ...
... of,Hematology (ASH), the world,s largest professional society of ... Committee, the,governing body of the organization. The officers ... J. Evan Sadler, MD, PhD, will serve a ... as president-elect and president. Charles,Abrams, MD, will serve ...
Cached Medicine News:Health News:Smokers' Homes More Likely to House Hungry Kids 2Health News:Smokers' Homes More Likely to House Hungry Kids 3Health News:Vericept Announces 100 Customers in Healthcare Industry for Sensitive Data Protection 2Health News:Jennerex To Present at Rodman & Renshaw 10th Annual Healthcare Conference 2Health News:Capital BlueCross Acquires Dominion Dental 2Health News:New Leadership Elected to the American Society of Hematology 2
(Date:5/20/2013)... , May 20, 2013  B. Braun Medical ... and environmental safety with products, services and education ... feature its innovative Outlook® 400ES and Space Infusion ... capabilities at the American Association of Critical-Care Nurses ... Boston Convention Center. ...
(Date:5/20/2013)... 2013  Uroplasty, Inc. (Nasdaq: UPI ) ... the fiscal fourth quarter and full year ended March ... 30, 2013. The Company will host a conference call ... 30, 2013 at 4:30 p.m. Eastern Time (3:30 p.m. ... call should dial 888-549-7750, no passcode is necessary. To ...
(Date:5/20/2013)... , May 20, 2013 /PRNewswire-iReach/ -- It is no secret ... third being overweight or obese gyms and supplement companies are ... the condition is primarily related to dietary issues and a ... the result of a glandular problem or even a vitamin ... common vitamin deficiency is a lack of vitamin b12 ...
Breaking Medicine Technology:B. Braun Committed To Improving Patient Safety 2Uroplasty To Announce Fiscal Fourth Quarter And Full Year 2013 Financial Results On May 30, 2013 2USB12Shots.com Discusses the Possibility of B12 Shots for Weight Loss 2
... LOUIS, Oct. 12 Orion Genomics today announced that ... agreement with the molecular diagnostics unit of Novartis Pharma ... novel epigenetic biomarkers, and both parties have rights to ... fields. Under the terms of the agreement, Orion ...
... VIENNA, Austria, October 12 ... enzymes for the,chemical industry, announced today that it ... position of Senior Vice President Marketing &,Sales. Dr. ... of EUCODIS,Bioscience, products. In 2009 the Company has ...
Cached Medicine Technology:Orion Genomics Enters Discovery Collaboration and License Agreement to Advance Personalized Diagnostics 2EUCODIS Bioscience Appoints Bhupinder Hundle to Senior Vice President Marketing & Sales 2EUCODIS Bioscience Appoints Bhupinder Hundle to Senior Vice President Marketing & Sales 3
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
Made exclusively from LactoSorb Resorbable Copolymer....
... The Biosteon™ screw is made of ... Acid (PLLA). It not only has the ... it has the osteoconductive potential of bone. ... BTB and Soft Tissue procedures. Biosteon™ increases ...
The Stryker Graft Workstation offers the surgeon flexibility in graft preparation. The posts are interchangeable and the system adapts to both soft tissue and bone grafts selection. Sizing gauges off...
Medicine Products: