Navigation Links
Protein clamps tight to telomeres to help prevent aging ... and support cancer
Date:9/16/2010

if such repair proteins fuse the ends of two chromosomes together, for example. Secondly, Cdc13 recruits telomerase and related proteins to place in order to lengthen the telomeres.

When the researchers introduced mutations into Cdc13 that prevented the protein from forming a dimer, it caused the telomeres to shorten, which would hasten the demise of the yeast cells. When they created mutations that prevented Cdc13 dimers from binding to DNA, it had the effect of excessively lengthening telomeres, an act the researchers attribute to the notion that Cdc13 helps regulate the ability of DNA-replication enzymes to access telomeres.

"The complex role of Cdc13 underscores the unique nature of telomeres and the fine balance between normal cell division and cancer," said Skordalakes.

Telomeres are important to cell division because they serve as sort of a timing mechanism that can, in effect, limit the number of times a normal cell can divide. As each cell divides, it must first replicate or copy the DNA of its chromosomes in exacting detail.

However, the proteins in cells that make this replication possible physically cannot copy the last few base units of DNA at the tips of the chromosomes, which effectively shortens the telomere each time a chromosome is copied. Without telomeres to serve as a buffer, a chromosome could conceivably lose a functioning gene as it is copied. This natural "lifespan" of cells was first identified in the 1960s as the Hayflick Limit, named after its discoverer, Leonard Hayflick, Ph.D., then a Wistar scientist.

In 2008, the Skordalakes laboratory was the first to determine the 3-D structure of the catalytic subunit of the enzyme telomerase, which functions to tack on the short stretches of DNA at the telomeres that the cell's main DNA-replicating enzymes miss. The act of preserving telomeres through telomerase is a hallmark of only certain cells, particularly those in developing embryos. In adu
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... nearly 20 years, June Cotner has been the go-to ... life's rites of passage. Here, she joins forces with ... Toasts: The Perfect Words to Celebrate Every Occasion , ... and containing many original toasts written just for this ... contains sayings famous and profound, suitable and sentimental. Covering ...
(Date:12/24/2014)... December 24, 2014 “ Relax Melodies ... monthly AppWatch, which features the latest and coolest mobile ... Tropeano, a mobile technology expert and host of NewsWatch, ... this application soothes users so they can fall asleep. ... of adults say they have some sort of difficulty ...
(Date:12/24/2014)... As 2014 draws to a close, ... time and money into a new or tankless water ... in tankless and eco-friendly products or service. Greenstar urges ... in 2015 to research “green” and environmentally friendly options ... Services specializes in eco-friendly and environmentally conscious products ...
(Date:12/24/2014)... 24, 2014 Dr. Ronald Receveur, a ... experience placing dental implants in a day, ... effects of overusing teeth-whitening treatments. , In his ... , Dr. Receveur writes that overusing teeth-whitening treatments can ... damage to enamel. , “Because teeth-whitening treatments ...
(Date:12/24/2014)... Kathleen Doheny HealthDay Reporter ... steady diet of fast food might hurt your child in ... ate fast food in fifth grade lagged behind by eighth ... more than 8,500 U.S. students. "The largest effects were ... food," said study leader Kelly Purtell, assistant professor of human ...
Breaking Medicine News(10 mins):Health News:An Application to Help with Insomnia was Featured on NewsWatch Television on December 19, 2014 2Health News:Greenstar Home Services Offers Tankless Water Heater Advice to Local Homeowners 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 3Health News:Can Fast Food Hinder Learning in Kids? 2
... in French . Montreal, September 1, 2009 ... bacteria from the skin of the fruit, holds great promise ... the International Journal of Obesity , was conducted by ... the Universit de Moncton who tested the effects of biotransformed ...
... , , CHICAGO, Sept. 1 ... launched a new online video series, called " Living Positive By ... and AIDS education initiative. The Living Positive By Design ... to encourage thoughtful conversations about HIV and AIDS, to confront HIV ...
... , SEARCY, Ark., Sept. 1 Fourteen ... this year,s National Day of Encouragement with the first ever "7 ... The tour will launch September 5 in San Francisco and conclude ... and commemoration of the third annual National Day of Encouragement in ...
... , WASHINGTON, Sept. 1 The ... Tobacco-Free Kids: , , (Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) ... Tobacco Company, Lorillard Inc. and other tobacco manufacturers that they have ... legislation is not unexpected. The lawsuit, filed in the federal court ...
... , CINCINNATI, Sept. 1 ... physician office-based patient-education programs has announced that SIGVARIS, the ... expanding to the Skin Care Network to broaden their ... office is an ideal place to increase the awareness ...
... MILFORD, Mass., Sept. 1 Waters Corporation (NYSE: ... Division of the American Chemical Society presented Prof. John R. ... Achievements by a Young Analytical Scientist. Through a ... the combined use of hydrogen-deuterium (H/D) exchange technology ...
Cached Medicine News:Health News:Biotransformed blueberry juice fights fat and diabetes 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 3Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 2Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 3Health News:'7 Days Across America' Campaign Honors Teens Making a Difference in Their Communities 4Health News:RJR, Other Tobacco Companies Go to Court to Evade Regulation by FDA 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 3Health News:American Chemical Society Awards John R. Engen for Scientific Achievements 2Health News:American Chemical Society Awards John R. Engen for Scientific Achievements 3
(Date:12/24/2014)...   Assurex Health, a personalized medicine company ... for behavioral health and chronic pain conditions, today ... equity financing from new and existing investors, according ... Chief Executive Officer. The financing will ... Health,s GeneSight ®  products.  GeneSight,s patented ...
(Date:12/24/2014)... Dec. 23, 2014 Tianyin Pharmaceutical Co., ... specializes in patented biopharmaceutical, modernized traditional Chinese medicine ... today announced that the Company achieved the Public ... Practice (GMP) certificate of TPI,s Qionglai Facility (QLF) ... The public notice period is a significant procedure ...
(Date:12/24/2014)... CHAPEL HILL, N.C. , Dec. 23, 2014 /PRNewswire/ ... marketplace success. As the key link between the medical ... will grow even more in the coming years as ... relationships. According to research by benchmarking ... and MSLs can gain an important edge is by ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... is established. Provides a robust and durable ... positioning on the globe. Pressure Ridge Molteno ... covered by Tenons tissue, acts as a ... The range of implants allows the surgeon ...
... implant is the first glaucoma implant designed ... pars plana vitrectomy. The Hoffman Elbow was ... gauge pars plana sclerostemy incision. Baerveldt Glaucoma ... the largest surface area in a streamlined ...
... enough to shuttle easily between offices in ... a goldmann standard 30 cm radius bowl. ... locations (including 30-2, 24-2, and 10-2) to ... out to 30. Easyfield is so ...
... 311 has additional hardware and software features ... most demanding clinics or teaching institutions. Standard ... test parameters for experimental or clinical studies. ... Capacity for further tests including Flicker- and ...
Medicine Products: