Navigation Links
Protein clamps tight to telomeres to help prevent aging ... and support cancer
Date:9/16/2010

The number of times our cells can divide is dictated by telomeres, stretches of DNA at the tips of our chromosomes. Understanding how telomeres keep our chromosomes and by extension, our genomes intact is an area of intense scientific focus in the fields of both aging and cancer. Now, scientists at The Wistar Institute have published the first detailed report on the structure and function of a crucial domain in the protein known as Cdc13, which sustains telomeres by clamping to DNA and recruiting replicating enzymes to the area.

While the nature of this portion of Cdc13 had previously eluded scientists, the Wistar researchers found that two copies of the protein bind together to form what is called a "dimer," and how that dimer physically interacts with DNA, regulating how enzymes called telomerases access and lengthen the telomeres. The study was performed using the yeast gene, however, this essential life process has changed little through evolution, and evidence suggests that the human equivalent of this protein may make a good target for future anticancer drugs. They present their findings in the journal Molecular and Cellular Biology, available online now, ahead of print.

"Cdc13 has a crucial support role in maintaining and lengthening telomeres, which are reduced in length through every round of DNA replication," said Emmanuel Skordalakes, Ph.D., assistant professor in Wistar's Gene Expression and Regulation Program and senior author of the study. "We know that disabling this protein in humans will most likely lead to senescence, which is of particular interest in cancer, because telomere lengthening is one of the ways cancer cells obtain their immortality."

In the present study, Skordalakes and his colleagues detail how Cdc13 serves a dual function in telomere replication. First, it keeps the cells' natural DNA repair mechanisms from mistaking the telomere for a broken stretch of DNA, which could cause genetic mayhem
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- As kids transition from ... of cyberbullies, according to a recent study. ... through 8 found that verbal and physical bullying declines ... bullying intervention and prevention strategies must address all types ... boys and girls, the researchers said. The study was ...
(Date:9/19/2014)... Visiting Nurse Association (VNA) Health Group, ... hospice and palliative care and community-based care, was honored ... yesterday at the New York Stock Exchange. , Founded ... entrepreneur to care for immigrant families suffering from tuberculosis ... to meet the urgent healthcare needs of the communities ...
(Date:9/19/2014)... Sept. 19, 2014 (HealthDay News) -- Pregnant women who live ... or low birth weight babies, a new study suggests. ... Canada, and found that expectant mothers who lived in a ... a 20 percent lower risk of very preterm birth (before ... preterm birth (30 to 36 weeks). Babies born to ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Lipitor lawsuits ... caused some patients to develop Type 2 diabetes continue ... underway in U.S. District Court, District of South Carolina, ... issued on September 12, 2014, discovery is underway and ... report noted that Pfizer, Inc., the manufacturer of Lipitor, ...
(Date:9/19/2014)... 2014) - New research published today in the online ... could reach 6,800 in West Africa by the end ... enacted. , Arizona State University and Harvard University ... of rise in cases significantly increased in August in ... quarantine was put in place, indicating that the mass ...
Breaking Medicine News(10 mins):Health News: Cyberbullying Seems to Ramp Up in Middle School 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3Health News:Do Greener Neighborhoods Produce Healthier Babies? 2Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuits Move Forward, as Discovery Proceeds in Federal Multidistrict Litigation, Bernstein Liebhard LLP Reports 3Health News:Research predicts possible 6,800 new Ebola cases this month 2
... is one of the leading causes of blindness. The cause ... raised pressure within the eye, (the intraocular pressure), that can ... damage results in poor blood supply or weak end eye ... the optic nerve leading to the brain. Fluid enters and ...
... imaging test may identify patients with the gene mutation ... Doppler tissue imaging (DTI) as a more powerful way ... Hypertrophic cardiomyopathy (HCM) causes thickening of the left ventricle ... of sudden cardiac death in the young, affecting one ...
... recent study, the researchers confirmed that people who consume high ... lungs. And for the first time, the research showed that ... decline in lung function over time.// Just like an apple ... may help keep lung disease away, according this new research. ...
... makes detection more easier. A combined scanner detects more ... method. It is notoriously difficult to get an accurate ... is dense and so it's not always possible to ... at the University of Texas now say that combining ...
... to a recent study, a rare genetic condition has uncovered ... unusual childhood genetic disorder marked by bone marrow failure. If ... of a number of cancers, including brain, head and neck, ... and the Children's Hospital, Boston, have been studying a number ...
... Hormone replacement in patch form improves mood and libido ... difficulty reaching orgasm and painful intercourse. They assume it's ... no licensed treatment for these symptoms. ,But a ... California reveals that the patch form of hormone replacement ...
Cached Medicine News:Health News:Vitamin C maintains healthy lungs 2
(Date:9/19/2014)... Sept. 19, 2014 Five MinuteClinic walk-in medical clinics are ... metropolitan area. Three clinics opened in Memphis ... fourth clinic will be added in Springfield ... is expected to open October 22.  MinuteClinic is the ... the United States . The ...
(Date:9/19/2014)... Sept. 19, 2014  Alere Inc. (NYSE: ... the following statement today in support of President ... "As the global leader in rapid diagnostics for ... national strategy to address the serious threat of antibiotic ... the Administration on initiatives to promote the development of ...
(Date:9/19/2014)... 19, 2014  BioSpecifics Technologies Corp. (NASDAQ: BSTC ... marketed as XIAFLEX ® in the U.S. and XIAPEX ... Tom Wegman , will present a corporate overview at ... Industry Conference. The presentation will take place ... the Millennium Broadway Hotel in New York, NY ...
Breaking Medicine Technology:MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2
... NEW YORK, May 25, 2011 ... research report is available in its ... Devices Market Outlook in United Kingdom ... Devices, Infusion Systems, Central Venous Catheters ...
... May 25, 2011 Reportlinker.com announces that ... in its catalogue: Triple ... http://www.reportlinker.com/p0284714/Triple-Analysis-Lymphoma-Pancreatic-Cancer-and-Prostate-Cancer.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... drug development strategies in Lymphoma, Pancreatic Cancer ...
Cached Medicine Technology:Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 2Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 3Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 4Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 5Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 6Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 7Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 8Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 9Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 10Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 11Reportlinker Adds Drug Delivery Devices Market Outlook in United Kingdom to 2017 - Metered Dose Inhaler Devices, Infusion Systems, Central Venous Catheters and Needle Free Injections 12Reportlinker Adds Triple Analysis: Lymphoma, Pancreatic Cancer and Prostate Cancer 2Reportlinker Adds Triple Analysis: Lymphoma, Pancreatic Cancer and Prostate Cancer 3Reportlinker Adds Triple Analysis: Lymphoma, Pancreatic Cancer and Prostate Cancer 4Reportlinker Adds Triple Analysis: Lymphoma, Pancreatic Cancer and Prostate Cancer 5
... 1064 is a laser system with one single ... maximum continuous intensities of either 60 W or ... in all-mini-invasive surgical techniques. This laser is the ... the most requested from hospitals and clinics which ...
Smart Chill is a compact cooling system that provides intense localised skin cooling through a comfortable contact handpiece....
... been designed exclusively for vascular treatments, Smart VS ... range which ensures fast amortisation of the investment ... can be fitted with a polarised light viewing ... to be treated as well as the operators ...
... Erbium (Er:YAG) laser is the ideal instrument ... Smart 2940 Plus, the majority of surface ... a wide range of scar tissue, with ... most cases with the elimination of anaesthetics, ...
Medicine Products: