Navigation Links
Protein causes varicose veins
Date:11/4/2011

Varicose veins, sometimes referred to as "varices" in medical jargon, are usually just a cosmetic problem if they occur as spider veins. In their advanced stage, however, they pose a real health threat. In people with this widespread disorder, the blood is no longer transported to the heart unhindered but instead pools in the veins of the leg. This is because the vessel walls or venous valves no longer function adequately. Dr. Thomas Korff and his group at the Division of Cardiovascular Physiology (Director: Prof. Markus Hecker) of Heidelberg University's Institute of Physiology and Pathophysiology have now shown that the pathological remodeling processes causing varicose veins are mediated by a single protein.

As a response to increased stretching of the vessel wall, this protein triggers the production of several molecules promoting changes in wall architecture. The paper published in the current issue of FASEB Journal may offer a possibility for using drugs to decelerate the formation of or even prevent new varicose veins.

Previously, no suitable experimental systems existed for studying the way in which these changes in the cells of the blood vessels are controlled. For their studies, Korff and his team took advantage of the fact that blood vessels in the mouse ear are clearly visible and are also easily accessible for minor surgical procedures. In order to artificially set off processes that are similar to the formation of varicose veins, they tied off a vein with a thin thread. The elevated pressure in the vessels caused by the pooled blood led to the recognizable remodeling characteristic of varicose veins. In addition, in the affected veins, the cell proliferation rate and the production of MMP-2 increased. MMP-2 is an enzyme that breaks down the non-cellular components of the connective tissue of the blood vessels. On the other hand, there were no signs of an inflammatory response, which can be observed during other vessel remodeling processes.

Model allows agents to be tested

"Nevertheless, the cellular mechanisms that control the formation of varicose veins appear to be similar to mechanisms that orchestrate the remodeling of arteries in patients with high blood pressure," Korff explains. The transcription factor AP-1 which regulates the activity of certain genes and thus the corresponding protein production is regulated by the filling pressure in the blood vessels and in turn controls the formation of varicose veins, Korff adds. If AP-1 is inhibited, thus prohibiting it from activating genes, the characteristic corkscrew-like varicose veins do not form and cell proliferation and the production of enzymes that break down connective tissue remain at normal levels.

In a further experiment, the group showed that the results obtained in the mouse are also valid for humans. Varicose veins that have been surgically removed from patients exhibited the same cellular and molecular changes as the varicose veins created artificially in the mouse ear. Based on these results, Korff plans more studies. "Using our model, we can now more precisely analyze the early stages of the disorder and test possible drugs for their ability to prevent varicose vein formation, which, as a result, may improve the quality of life of afflicted patients."

According to the German Vascular League, 30 million people suffer from minor vein-related symptoms, whereby women are affected around twice as often as men. According to a health report published by the German government, 15 to 20 percent of the population has varicose veins.


'/>"/>

Contact: Dr. Gerd Koenig
gerd.koenig@physiologie.uni-heidelberg.de
49-622-154-4067
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Researchers identify structure of apolipoprotein
2. High levels of master heat shock protein linked to poor prognosis in breast cancer patients
3. Linking Fragile X Syndrome proteins and RNA editing mistakes at nerve-muscle junction
4. Inadequate supply of protein building blocks may explain pregnancy failures in bovine cloning experiments
5. Blood proteins predict survival in idiopathic pulmonary fibrosis, Pitt-led team says
6. Researchers find coupling of proteins promotes glioblastoma development
7. New study shows soy protein improves lipid profile in healthy individuals
8. Protein family key to aging, cancer
9. Protein May Help Spot Newborns With Brain Damage
10. Knockout of protein prevents colon tumor formation in mice
11. Abnormal Protein May Explain Loss of Smell With Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... (PRWEB) , ... February 27, 2017 , ... ... rehabilitation and alcohol treatment programs in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ , ... its team. The new hire, Mackenzie Alsager, showcases the Centre's commitment to innovation ...
(Date:2/26/2017)... ... February 26, 2017 , ... Today, ... the 7th Edition of International Social Design Awards. , The 7th A' ... System Designers, Governments and Institutions worldwide with realized projects and conceptual works. , ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... and reporting for healthcare organizations. This comprehensive and customizable solution empowers StaffBridge ... StaffBridge technology improves staffing efficiency, maximizes resource allocation, collects critical reporting data, ...
(Date:2/24/2017)... ... 24, 2017 , ... HealthPostures, expert standing desk solution designer, ... built into the home office sit stand solution are bold colors, a new ... the benefits embedded in the TaskMate Go are available 24/7 through HealthPostures' online ...
(Date:2/24/2017)... ... 2017 , ... Dr. Ronald E. Hawkins, vice president for ... Peter A. Bell, DO, MBA, HPF, FACOEP-dist., FACEP, as the new dean of ... Bell comes to Liberty from the Ohio University Heritage College of Osteopathic Medicine ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 24, 2017 Physician General Dr. ... and Alcohol Programs Jennifer Smith commended South ... training for and using naloxone, a life-saving overdose reversal ... , a recovery specialist and overdose survivor who was ... providers. "A significant part of fighting the ...
(Date:2/24/2017)... , Feb. 23, 2017 The U.S. ... the PhenoTest BC Kit, performed on the Pheno ... organisms that cause bloodstream infections and provide information ... respond to (antibiotic sensitivity). The test also reduces ... this important information, which can guide antibiotic treatment ...
(Date:2/24/2017)... -- Directors from Pharma To Market Pty Ltd and Ador Consulting Pte ... the founding of Pharma To Market Pte Ltd, based in ... to announce their expansion into Asia with ... The company are delighted to appoint Joelle Chia , former ... based entity. Joelle brings with her an extensive business ...
Breaking Medicine Technology: