Navigation Links
Protein build-up leads to neurons misfiring
Date:7/18/2012

Using a two-photon microscope capable of peering deep within living tissue, researchers at the University of California, San Diego School of Medicine have found new evidence that alpha-synuclein protein build-up inside neurons causes them to not only become "leaky," but also to misfire due to calcium fluxes.

The findings the first recorded in vivo using a transgenic mouse model of Parkinson's disease are published in the July 18 issue of The Journal of Neuroscience and provide new insights into how Parkinson's disease and other neurodegenerative disorders known as synucleinopathies work and progress at the cellular level.

Previous in vitro studies using cell cultures had suggested abnormal accumulation of alpha-synuclein dysregulated intracellular handling and movement of calcium, which is used as a signaling molecule and neurotransmitter. It was unclear, however, whether calcium alterations occurred in more complex, living animals.

"This is the first time we've been able to verify the role of alpha-synuclein aggregates in vivo," said senior author Eliezer Masliah, MD, professor of neurosciences and pathology.

"The aggregates affect the cell membrane of neurons, making them more porous. They also affect the membranes of organelles inside neurons, such as the mitochondria that are part of the cell's machinery for generating energy. Energy is necessary to pump calcium in and out of the cell. If mitochondria membranes are compromised, calcium accumulates, further damaging the neuron and causing it to misfire."

Masliah said the new revelations, made using imaging technologies developed by first author Anna Devor, PhD, associate adjunct professor of neuroscience, may help scientists and doctors quantify and repair neuronal damage caused by alpha-synuclein accumulation.

"We have already started to utilize this discovery as a bio-marker and reporter of neuronal damage," said Masliah. "We have compounds developed in collaboration with others to 'plug' the holes in the neurons and mitochondria and prevent the abnormal calcium currents. We can monitor in real-time in live animals how our drugs revert the toxic effects of alpha-synuclein. This represents a unique and fast strategy to evaluate novel compounds."


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Strong communication between brain and muscle requires both having the protein LRP4
2. Regulation by proteins outside cancer cells points to potential new drug target
3. Loss of protein SPDEF allows prostate cancer cells to gain foothold at possible sites of metastasis
4. The key (proteins) to self-renewing skin
5. Researchers discover rare leukemia-causing protein
6. PaleoMeal Organic Whey Protein Formula Improved According to Rockwell Nutrition
7. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
8. Researchers reveal crucial immune fighter role of the STING protein
9. Protein residues kiss, dont tell
10. Overexpression of proteins 14-3-3 related to chemotherapy resistance
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... Vayyar ... to see through objects, has announced the winners of its "Power to the ... fully programmable, Raspberry Pi-enabled 3D sensor, Walabot . Creators cast submissions on ...
(Date:6/28/2017)... ... June 28, 2017 , ... Continually at ... Liquid Stevia Sweet Drops™ have received the Non-GMO Project Verified seal. All five ... Non-GMO Project, the only third-party verification for non-GMO foods and products in North ...
(Date:6/28/2017)... ... ... remote control has seen the never-ending twists on the house flipping show genre. The shows ... time. But what about the buyers of the flipper's flip. , Here is ... An email recently sent to Gary Case said, “Just closed on a home on ...
(Date:6/28/2017)... , ... June 28, 2017 , ... American Farmer proudly ... episode of the award winning television series, scheduled to broadcast fourth quarter 2017. American ... originated as a regional supplier of garden pea seed. As demand grew, the small ...
(Date:6/28/2017)... , ... June 28, 2017 , ... ... County and the surrounding regions access to insurance assistance and financial planning services, ... 25: Ministries to assist families in the region facing financial crisis. , Matthew ...
Breaking Medicine News(10 mins):
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
(Date:5/26/2017)... , May 25, 2017  In response to ... , Direct Relief is working with Pfizer to ... available at no cost to community health centers, free ... providers nationwide. "Pfizer has a long-standing ... medicines and ensuring patient safety through educational activities," said ...
(Date:5/23/2017)... , May 23, 2017  Leaf Healthcare, recognized ... medical devices for pressure ulcer prevention, will unveil ... Association of Critical Care Nurses, National Teaching Institute ... The Leaf Patient Monitoring System is ... the hospital environment.  The system seamlessly tracks patient ...
Breaking Medicine Technology: