Navigation Links
Protein-based urine test predicts kidney transplant outcomes
Date:8/22/2013

Levels of a protein in the urine of kidney transplant recipients can distinguish those at low risk of developing kidney injury from those at high risk, a study suggests. The results also suggest that low levels of this protein, called CXCL9, can rule out rejection as a cause of kidney injury. The study appears online Aug. 22 in the American Journal of Transplantation. The work was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

To prevent rejection, kidney transplant recipients typically take immunosuppressive drugs every day. However, these drugs can cause kidney damage and lead to other serious side effects such as cancer, infection and infertility. Even with immunosuppressive therapy, 10 to 15 percent of kidney recipients experience rejection during the first year after transplantation.

Currently, the only definitive way to distinguish rejection from other causes of kidney injury is by performing a biopsy, in which doctors remove a small piece of kidney tissue to look for rejection-associated damage. Although this procedure is generally considered safe, it carries some minor risks for the patient and does not always provide an accurate impression of the overall state of the kidney.

"A noninvasive urine test to accurately monitor the risk of kidney rejection could dramatically reduce the need for biopsies and possibly enable doctors to safely reduce immunosuppressive therapy in some patients," said NIAID Director Anthony S. Fauci, M.D. "The results of this study support the further development of noninvasive tests for the detection and management of transplant rejection."

In this multicenter Clinical Trials in Organ Transplantation study, doctors periodically collected urine samples from 280 adult and child kidney transplant recipients for two years after transplantation. Investi
'/>"/>

Contact: Hillary Hoffman
hillary.hoffman@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Protein-based coating could help rehabilitate long-term brain function
2. Stem cells in urine easy to isolate and have potential for numerous therapies
3. Urine biomarker test can diagnose as well as predict rejection of transplanted kidneys
4. ATAGO Urine Specific Gravity Refractometers Continue to Catch Drug Test Cheaters
5. RI Hospital: Nearly half of older women diagnosed with UTI not confirmed in urine culture
6. Microscopic blood in urine unreliable indicator of urinary tract cancer
7. InventHelp Client Patents “LessMess” – Invention Could Reduce Messes and Smells Caused by Splashed Urine
8. Purines fend off surgery-related damage
9. In Diabetes, Any Protein in Urine May Signal Heart Risk
10. Low childhood conscientiousness predicts adult obesity
11. Novus Medical Detox Predicts Taxpayer-Paid Drug Abuse Amid Medicare Fraud, Urges Federal Regulations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 Beginning in September, K9 ... (DOG) as an interactive, fun way for daycare dogs ... to all K9 Dog Park Doggy Daycare clients who bring ... per week. Clients will be able to watch their ... The dogs that compete in D.O.G. will win prizes as ...
(Date:8/27/2014)... Aug. 26, 2014 (HealthDay News) -- Health care workers ... gear to keep them safe from being infected with ... study shows. While the study was conducted before ... spring, its findings are confirmed in statistics released Monday ... health agency reported that an "unprecedented" number of health ...
(Date:8/27/2014)... microGUNE, the Co-operative Research Centre into Microtechnologies, ... to generate innovative solutions based on microtechnologies ... industry and life sciences, among others. IK4-Ikerlan, ... are collaborating with CIC microGUNE on this ... by the Etortek 2013-2014 programme of the ...
(Date:8/27/2014)... This news release is available in German . ... need for medical agents to treat metastatic tumors. In case ... cancer that is often detected late, 95% of the patients ... amcure develops tumor therapeutic agents that might reduce this mortality ... has now received a total of EUR 5 million from ...
(Date:8/27/2014)... When a friend invited Misty Mozejko to join a ... the beginning of a new way of life and a new ... “I knew I needed to turn my life around but I ... Misty stuck with the program. “It was so difficult,” she laughs. ... my comfort zone, but between the boot camp and some good ...
Breaking Medicine News(10 mins):Health News:K9 Dog Park Announces Launch Of Daycare Olympic Games – D.O.G. 2Health News:K9 Dog Park Announces Launch Of Daycare Olympic Games – D.O.G. 3Health News:K9 Dog Park Announces Launch Of Daycare Olympic Games – D.O.G. 4Health News:Lack of Protective Gear Leaves Medics at Risk in Ebola Outbreak: Study 2Health News:Lack of Protective Gear Leaves Medics at Risk in Ebola Outbreak: Study 3Health News:Microtechnologies for driving forward mobility and human health 2Health News:Preclinical development of tumor therapeutic agent starts 2Health News:Whitby Fit Body Boot Camp Releases Gift Certificate for Two-Week Complimentary Access to Fitness Boot Camp 2Health News:Whitby Fit Body Boot Camp Releases Gift Certificate for Two-Week Complimentary Access to Fitness Boot Camp 3
... By Steven Reinberg HealthDay Reporter , MONDAY, Jan. ... with a small increase in the risk of heart attack, ... in Ohio looked at seven trials involving Pradaxa that included ... data from published clinical trials to tease out a pattern ...
... HealthDay Reporter , MONDAY, Jan. 9 (HealthDay News) -- ... new research that finds losing a loved one can increase ... a significant other,s death, heart attack risk was 21 times ... nearly 2,000 heart attack patients. And within the first week ...
... , MONDAY, Jan. 9 (HealthDay News) -- Nicotine patches and ... therapy" -- don,t help many smokers kick the habit ... This conclusion is based on results of several surveys ... who used nicotine replacement therapy (NRT) did not gain any ...
... Randy Dotinga HealthDay Reporter , MONDAY, Jan. 9 ... used by people trying to quit smoking could serve an ... older patients. The research is preliminary and only involved ... While they,re available over the counter, patches may cost several ...
... -- A 2010 outbreak of Legionnaires, disease in Wisconsin ... hospital lobby, according to a study published in the ... , the journal of the Society for Healthcare Epidemiology ... was detected among eight people in southeast Wisconsin, state ...
... (HealthDay News) -- Waiting up to a year to treat ... not harmful, but waiting many years to get blood pressure ... In the study, published online Jan. 9 in the ... University of Chicago suggested that the one-year delay could give ...
Cached Medicine News:Health News:New Blood Thinner Linked to Higher Heart Attack Risk 2Health News:New Blood Thinner Linked to Higher Heart Attack Risk 3Health News:Grief Is a Real Heartbreaker, Study Finds 2Health News:Grief Is a Real Heartbreaker, Study Finds 3Health News:Nicotine Patches, Gums Won't Help Smokers Quit Long-Term: Study 2Health News:Nicotine Patches, Gums Won't Help Smokers Quit Long-Term: Study 3Health News:Could Nicotine Patches Help Stave Off Memory Loss? 2Health News:Could Nicotine Patches Help Stave Off Memory Loss? 3Health News:Legionnaires' disease outbreak linked to hospital's decorative fountain 2Health News:Short Delay in Treating Blood Pressure Safe for Diabetics: Study 2Health News:Short Delay in Treating Blood Pressure Safe for Diabetics: Study 3
(Date:8/27/2014)... 2014 Reportlinker.com announces that a new ... Global Heart Valve Repair and Replacement ... About Heart Valve Repair and Replacement ... which control the flow of blood during the ... diseases such as valvular stenosis, valvular insufficiency or ...
(Date:8/27/2014)... -- Reportlinker.com announces that a new market research report ... Eastern Europe 2014 http://www.reportlinker.com/p02312454/Baby-Food-Eastern-Europe-2014.html ... a new report by ERC that analyzes the Baby ... , key segments, features & developments, future projections ... which are currently affecting the industry. Furthermore, it profiles ...
(Date:8/27/2014)... , Aug. 27, 2014 North American lighting ... prestigious R&D 100 Award for the new OSRAM ITOS ® ... LED-based white light module for microscopy, endoscopy and surgical head ... with significantly higher efficacy and lamp life. "We,re ... one of the most innovative new technologies of the past ...
Breaking Medicine Technology:Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4Baby Food Eastern Europe 2014 2Baby Food Eastern Europe 2014 3Baby Food Eastern Europe 2014 4Baby Food Eastern Europe 2014 5Baby Food Eastern Europe 2014 6Baby Food Eastern Europe 2014 7Baby Food Eastern Europe 2014 8OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3
... Antibody (IgM) Test is an ... quantitative detection of antibodies to ... is used as an aid ... thrombosis in individuals with systemic ...
The 8500 is an extremely reliable portable pulse oximeter, requiring no periodic maintenance or calibration....
Rad-5v signal extraction pulse oximeter™...
... The 8500 Digital Handheld ... universal tool for patients monitoring ... continuous monitoring. As the first ... as a benchmark for durability ...
Medicine Products: