Navigation Links
Protein balance key in preventing cancer
Date:2/27/2013

PHILADELPHIA, PA (February 27, 2013)Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the February 25 issue of Developmental Cell by scientists at Fox Chase Cancer Center. The results suggest that new compounds could fight cancer by targeting the pathways responsible for maintaining the proper balance between the proteins.

"It's our job now to understand how we can intervene therapeutically in this system, so we can restore balance when it's thrown off," says study author David L. Wiest, PhD, professor and deputy chief scientific officer at Fox Chase.

The two proteins"Rpl22" and "Rpl22-like1", which contribute to the process by which additional cellular proteins are madeare created from two similar genes, leading researchers to previously believe they were performing identical functions in the body. "What we're finding is that is absolutely not true," says Wiest. "Not only are they performing different functions, they are antagonizing each other."

During the study, Wiest and his team knocked out Rpl22 in zebrafisha common model of human disease. Without Rpl22, the zebrafish don't develop a type of T cells (a blood cell) that helps fight infections. The same developmental defect was observed when they knocked out Rpl22-like1, indicating that both proteins are independently required to enable stem cells to give rise to T cells.

But when the researchers tried to restore T cells in zebrafish that lacked Rpl22 by adding back Rpl22-like1, it didn't work. The reverse was also trueRpl22 was not enough to restore function after the researchers eliminated Rpl22-like1. These results led Wiest and his team to believe that, although the proteins are both involved in producing stem cells, they do not perform the same function.

To learn more about the
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... ... Author Francesca Camp wasn’t always a steadfast supporter of plastic surgery. But just ... of the practice; a terrible car accident years ago left her injured and in need ... It ? (And What if I Do?): Answers to All Your Questions about Plastic Surgery” ...
(Date:7/1/2015)... ... 2015 , ... After conducting a nationwide executive search ... Center in Oceanside, Calif., has hired Cheryle Bernard-Shaw as chief compliance officer. ... efforts and growing a focus on risk management, Bernard-Shaw will assume her new ...
(Date:7/1/2015)... ... July 01, 2015 , ... Incentivizing the use of generic drugs ... discounts as much as 80% or 90% off the prices for the brand-name products. ... act to mitigate the financial impact of these high-cost generic drugs. The July issue ...
(Date:7/1/2015)... Beach, CA (PRWEB) , ... July 01, 2015 ... ... has returned to the Northbound team as Director of Referral Relations. , ... programs, including Northbound’s Collegebound, where she designed and implemented unique academic curriculum for ...
(Date:7/1/2015)... ... July 01, 2015 , ... The Thule Atmos X4 offers ... tested to ensure it lived up to Thule’s rigorous standards. Due to its Bi-ComponentArmor ... quality Thule owners have come to expect. , The Thule Atmos X4 ...
Breaking Medicine News(10 mins):Health News:Francesca Camp’s New Book Unmasks Plastic Surgery Advice 2Health News:Tri-City Medical Center Hires New Chief Compliance Officer 2Health News:Tri-City Medical Center Hires New Chief Compliance Officer 3Health News:Blues Execs Share Strategies for Managing Generic Drug Inflation in AIS Newsletter 2Health News:Blues Execs Share Strategies for Managing Generic Drug Inflation in AIS Newsletter 3Health News:Northbound Treatment Services Welcomes Emily Orrick as Director of Referral Relations 2
... A new study presented at the Annual Congress for Dermatological ... supplement marketed by Paris-based IsoCell Nutra, significantly increased the levels ... claim that SOD has a different mode of action to ... first discovered in 1968, it is the first antioxidant mobilized ...
... reduce the bulging girth of the abdomen in middle aged and ... who have conducted a study showed that regular practice of yoga ... years can lead to arrest of weight gain in obese people ... collected from 15,500 men and women in the age group of ...
... Asia. Foreigners often come to this side of the content ... in their own countries. ,More and more Globetrotters are ... during the monsoons. Why you may ask? Well it’s believed ... therapy is in the rainy months of June, July and ...
... in Pakistan has shown that handwashing ,with soap prevents ... lower respiratory infections. ,These two infections have ... under 5 years of age ,every year in the ... socio economic groups. ,In the current study done in ...
... after consumption of abortion pill cause concern to women consuming ... physicians regarding the latest reports of death of 5 women ... also called as Mifeprex or Mifepristone. Mifeprex is an approved ... The drug was introduced in the market five years ago. ...
... patients have died amid a strike by junior doctors at ... third day Saturday crippling medical services. ,Two patients died ... patients, mostly poor people who have come for treatment from ... real victims of the strike because there is no doctor ...
Cached Medicine News:Health News:New Supplement Found To Be Effective Against Sunburn 2Health News:Ayurvedic Therapies Cashing In On Medical Tourism 2Health News:Fresh warnings to doctors regarding abortion pill 2
(Date:7/1/2015)... FRANCISCO , July 1, 2015 ... market) is expected to reach USD 49,119.2 million by ... Research, Inc. Monitoring services is expected to remain the ... of USD 1,227.5 million in 2012, and an estimated ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , Browse ...
(Date:6/30/2015)... Scotland , July 1, 2015 ... joins Nu C ana team   ... ProTide technology to develop and commercialise a portfolio of ... Chris McGuigan as Chief Scientific Officer. ... ProTide technology. He is currently Professor of Medicinal Chemistry ...
(Date:6/30/2015)... , June 30, 2015 Velos, Inc., the ... continues to grow and add customers who receive Clinical ... the 62 CTSAs awarded by the National Institutes of ... management. This is among the largest such market shares ... in the CTSA community keeps growing as a result ...
Breaking Medicine Technology:mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 2mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 3mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 4mHealth Market Worth $ 49,119.2 Million By 2020: Grand View Research, Inc. 5Internationally Renowned Medicinal Chemist Professor Chris McGuigan Appointed as NuCana's Chief Scientific Officer 2Internationally Renowned Medicinal Chemist Professor Chris McGuigan Appointed as NuCana's Chief Scientific Officer 3Velos continues adding CTSA customers - 40% now use Velos products 2
... 2011 The Mobile Dog Heart Health Tour is heading ... health examinations at Dreher Dog Park. From 1 to 5 ... on-site heart screenings in a soundproof medical unit, as well ... (Photo:   http://photos.prnewswire.com/prnh/20110127/CG37759 ) Since early 2009, veterinarians ...
... Lotus Pharmaceuticals, Inc. (OTC Bulletin Board: LTUSD) ("Lotus" or ... of medicine and drugs in the People,s Republic of ... investor interest, the Company has obtained land price guidance ... wishes to provide additional details regarding its 2008 purchase ...
Cached Medicine Technology:Vets to Provide Free Dog Heart Checks in West Palm Beach 2Vets to Provide Free Dog Heart Checks in West Palm Beach 3Lotus Pharmaceuticals Provides Inner Mongolia Land Price Guidance from Cha You Qian Qi Government 2
... Level 1 enables hospitals ... patient monitors to a ... Our temperature monitoring disposale ... are superior in their ...
... The pause of a heartbeat. The bodys ... rhythmic breathing. These vital signs are yours ... DeRoyals line of Temperature Monitoring products helps ... information needed to provide the most comfortable ...
... a heartbeat. The bodys warmth beneath drapes. ... vital signs are yours to guard, measure, ... Temperature Monitoring products helps you do your ... provide the most comfortable and precise management ...
... The bodys warmth beneath drapes. The life-giving ... are yours to guard, measure, stabilize and ... products helps you do your job, giving ... most comfortable and precise management of your ...
Medicine Products: