Navigation Links
Protein balance key in preventing cancer
Date:2/27/2013

PHILADELPHIA, PA (February 27, 2013)Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the February 25 issue of Developmental Cell by scientists at Fox Chase Cancer Center. The results suggest that new compounds could fight cancer by targeting the pathways responsible for maintaining the proper balance between the proteins.

"It's our job now to understand how we can intervene therapeutically in this system, so we can restore balance when it's thrown off," says study author David L. Wiest, PhD, professor and deputy chief scientific officer at Fox Chase.

The two proteins"Rpl22" and "Rpl22-like1", which contribute to the process by which additional cellular proteins are madeare created from two similar genes, leading researchers to previously believe they were performing identical functions in the body. "What we're finding is that is absolutely not true," says Wiest. "Not only are they performing different functions, they are antagonizing each other."

During the study, Wiest and his team knocked out Rpl22 in zebrafisha common model of human disease. Without Rpl22, the zebrafish don't develop a type of T cells (a blood cell) that helps fight infections. The same developmental defect was observed when they knocked out Rpl22-like1, indicating that both proteins are independently required to enable stem cells to give rise to T cells.

But when the researchers tried to restore T cells in zebrafish that lacked Rpl22 by adding back Rpl22-like1, it didn't work. The reverse was also trueRpl22 was not enough to restore function after the researchers eliminated Rpl22-like1. These results led Wiest and his team to believe that, although the proteins are both involved in producing stem cells, they do not perform the same function.

To learn more about the
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... Increases in household, construction and ... treatment volumes. However, government regulations and higher landfill ... According to IBISWorld industry analyst Alen Allday, “over ... at reducing the volume of waste generated, and ... Still, a large proportion of waste generated by ...
(Date:9/20/2014)... York (PRWEB) September 20, 2014 ... to grow in federal court, Bernstein Liebhard LLP ... Drug Administration (FDA) have voted overwhelmingly to recommend ... in men be subjected to further study in ... a report published on September 18th by Bloomberg.com, ...
(Date:9/20/2014)... Sept. 20, 2014 (HealthDay News) -- As flu season ... infection is to get a flu shot and a ... A primary care doctor can vaccinate people against the ... patients may have. Retail stores may provide flu shots ... advice, said Dr. Jorge Parada, medical director of infection ...
(Date:9/20/2014)... New York (PRWEB) September 20, 2014 ... morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological surgeries ... yet another insurer has announced plans to end ... posted on its website last month, Harrisburg, Pennsylvania-based ... effective November 1, 2014. The insurer said its ...
(Date:9/20/2014)... Traditionally dentists have advised their patients against drinking coffee and ... re-visiting that advice and changing his stance after considering two ... on oral health. “There’s good news and great news,” says ... in protecting against gum disease, and red wine can help ... from the September 2014 issue of Boston University School ...
Breaking Medicine News(10 mins):Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Get a Flu Shot During Checkup, Doctor Says 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3
... Breakthroughs in the Field , , ... and the American Friends of The Hebrew University ... co-chair of the Bill & Melinda Gates Foundation, with its inaugural ... New York Hilton. , , ...
... MEXICO CITY and PRINCETON, N.J., Dec. 5 MetLife ... life insurance company in Mexico, and a leading provider ... today that it has partnered with Assist America, Inc., ... through employee benefit plans, to protect 500,000 of its ...
... soon be possible, thanks to a discovery made by ... Coastal Health Research Institute neuroscience researchers. , The researchers ... previously found to that cause cell death following a ... following head trauma or a stroke. , The findings, ...
... A Better Tomorrow, a fast growing,Southern California-based rehabilitation center, is ... and the United,States. , ... for their,addictions," said Sylvia Reynolds, a bilingual therapist from A ... "And these calls are ...
... and Families Embrace Life to the Fullest , ... a world-leading developer and marketer of innovative medical technologies for ... the new global lifestyle magazine for people with an ostomy. ... articles on living a healthy and active life after ostomy ...
... Anthem Blue Cross and Blue Shield,in New Hampshire has ... the current issue of U.S. News & World Report/NCQA America,s ... best health plans,is the result of outstanding overall performance in ... Anthem Blue Cross and Blue Shield ...
Cached Medicine News:Health News:Event Honoring Bill Gates Raises Over $1.5 Million for Sustainable Agriculture Research at The Hebrew University of Jerusalem 2Health News:Event Honoring Bill Gates Raises Over $1.5 Million for Sustainable Agriculture Research at The Hebrew University of Jerusalem 3Health News:MetLife Mexico Life Insurance Company Partners with Assist America for Global Emergency Medical Assistance Services 2Health News:New target discovered to treat epileptic seizures following brain trauma or stroke 2Health News:Southern California Rehabilitation Clinic is Hiring Bilingual Therapists to Better Serve the Hispanic Communities of Mexico and the United States 2Health News:ConvaTec Launches New Lifestyle Magazine for People With an Ostomy 2Health News:Anthem Blue Cross and Blue Shield in New Hampshire Ranks Among Top Insurers on U.S. News & World Report / National Committee for Quality Assurance Best Health Plans List 2Health News:Anthem Blue Cross and Blue Shield in New Hampshire Ranks Among Top Insurers on U.S. News & World Report / National Committee for Quality Assurance Best Health Plans List 3
(Date:9/19/2014)... The American Association for Homecare (AAHomecare) is ... has joined the AAHomecare Corporate Partner Program. ... have been actively involved in AAHomecare for much of ... grown into a major global manufacturer of home medical ... to increase efforts on behalf of the HME sector ...
(Date:9/19/2014)... 2014 Larry J. Merlo , President and ... speak before the National Press Club in Washington, ... move to stop selling tobacco products and its leadership in ... "Dramatic changes in our health care system pose ... Merlo has said. "CVS Health has a truly unique combination ...
(Date:9/19/2014)...  Lpath, Inc. (NASDAQ: LPTN ), ... today that it has entered into definitive agreements ... and 3,605,042 unregistered warrants in a registered direct ... share of common stock and one unregistered warrant ... will be $3.475.  The warrants have an exercise ...
Breaking Medicine Technology:Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3
... , BEDFORD, Ohio , Jan. 14 ... is pleased to announce FDA approval for the addition of ... line. This product is AP rated and is equivalent to ... for oropharyngeal and esophageal candidiasis, cryptococcal meningitis, and is indicated ...
... , , BETHLEHEM, Pa. , Jan. 13 ... and easy-to-use WHIN ® Safe Huber Needle , an implantable ... a single Huber Needle and provides clinicians with advanced protection ... http://www.newscom.com/cgi-bin/prnh/20081022/NYW008LOGO ) , There are three models of the WHIN ® ...
Cached Medicine Technology:Bedford Laboratories(TM) To Begin Shipping Fluconazole Injection 2Bedford Laboratories(TM) To Begin Shipping Fluconazole Injection 3Bedford Laboratories(TM) To Begin Shipping Fluconazole Injection 4B. Braun Introduces WHIN(R) Safe Huber Needle 2B. Braun Introduces WHIN(R) Safe Huber Needle 3B. Braun Introduces WHIN(R) Safe Huber Needle 4
... broad selection of tip styles for ... ophthalmic procedures. Each single use cautery ... safety cap to lock switch in ... in use, and carries a 3-4 ...
... a broad selection of tip styles ... of ophthalmic procedures. Each single use ... a safety cap to lock switch ... not in use, and carries a ...
... Accu-Temp Cauteries provide a broad selection ... a wide variety of ophthalmic procedures. ... sterile, complete with a safety cap ... " position when not in use, ...
... The B-VAT® PC visual acuity system ... features of the B-VAT II. The system ... sequencing, contrast sensitivity testing and animated characters. ... the operator has single letter, single line ...
Medicine Products: