Navigation Links
Protein a possible key to allergy and asthma control
Date:1/2/2008

sed on the proteins distinctive structure. To investigate what else Siglec-8 might inhibit, the scientists activated the protein in mast cells once again with antibodies. Then, they attempted to trigger an allergic response from these cells.

Normally, mast cells respond with an outpouring of histamine, prostaglandins and other substances that spur allergic reactions in other cells. However, Bochner and his colleagues found that cells with activated Siglec-8 released less than half the typical amount of these substances.

Extending their experiment from cells to whole tissues, Bochner and his colleagues used antibodies to activate mast cells Siglec-8 in small pieces of human lung saved from autopsies. When the researchers triggered the cells to release their payloads-an act that typically causes airways to sharply constrict-the contractions were about 25 percent weaker than in lung tissue where the mast cells Siglec-8 wasnt activated.

The researchers are still unsure exactly how Siglec-8 inhibits mast cells from releasing their immune-triggering chemicals. However, follow-up experiments suggested that activating the protein keeps calcium from moving efficiently into the cells. Mast cells need this calcium signal to release their contents.

Bochner notes that researchers might eventually use these results, published in the February Journal of Allergy and Clinical Immunology, to develop a drug with this same effect. Such a drug would have the dual effect of blocking or reducing allergic reactions by killing eosinophils and preventing mast cells from releasing their substances.

Both of these effects could make allergic diseases and asthma less severe, he says. Its an intriguing approach because there are no drugs that specifically target both these cell types.

Though drugs exist that affect either eosinophils or mast cells, Bochner says developing a single drug that takes aim at both types of cells could be ev
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Pasadena, Calif. (PRWEB) May 22, 2015 ... where technology, communication and capacity are intersecting to ... and across society, the opening speaker at WesternU's ... , California Lieut. Gov. Gavin Newsom, a former ... was the keynote speaker at the graduation ceremony ...
(Date:5/22/2015)... 22, 2015 The American College of ... in June. They will hold a webinar on the ... two-day class on Classical Chinese Medicine. , Webinar – ... Steve Given, the Dean of Clinical Education, will lead ... First Professional Doctorate program. ACTCM is currently developing this ...
(Date:5/22/2015)... OH (PRWEB) May 22, 2015 River ... that Kyle Johnson, the health system’s Chief Financial Officer ... interests. Johnson has served as the company CFO since ... West will be joining the health system as CFO. ... an interim basis, while the Board of Trustees conducts ...
(Date:5/22/2015)... Following yesterday’s announcement that Ascenta Health ... health brand Nature’s Way, Marc St-Onge has affirmed his ... Skin is an integral part of the agreement with ... to further develop Ascenta Skin into a leading player ... a breakthrough, anti-aging skincare supplement featuring 6 active ingredients ...
(Date:5/22/2015)... Combination therapy, or polytherapy, will ... obstructive pulmonary disorder (COPD) as the dominant companies ... as well as Germany’s Boehringer Ingelheim compete with ... will market payers, clinicians and patients be disposed ... completely new ones? , In spite of recently ...
Breaking Medicine News(10 mins):Health News:Newsom to WesternU Grads: The Future is Inside You 2Health News:Newsom to WesternU Grads: The Future is Inside You 3Health News:ACTCM Announces Upcoming June Events 2Health News:River Valley Health Partners Announces CFO Transition, Appointment of Interim CFO 2Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2
... from the Children,s Cancer Hospital at The University of Texas ... to more accurately predict treatment outcomes in young leukemia patients ... test, also known as a CBC. The results ... of Pediatric Hematology Oncology,s (ASPHO) annual meeting today. The study ...
... or friends, survey finds , FRIDAY, April 9 (HealthDay News) ... most likely to sexually abuse children when, in fact, relatives ... By doing so, parents may be failing to give their ... it happens and try to stop it, the study authors ...
... ... the issue of “medication adherence.” , ... Alexandria, VA (Vocus) April 10, 2010 -- An article in the ... the National Association of Chain Drug Stores’ (NACDS) message that pharmacy’s role in helping ...
... in the United States has experienced a conflict with ... patient care, researchers from the University of Chicago report ... Journal of General Internal Medicine . Younger and ... conflicts than their older or more religious peers. Most ...
... early recover faster, reduce sedative use, research shows , FRIDAY, ... intensive care unit may reduce their use of sedatives and ... study has found. , The amount of prescription sedatives had ... which reduced the amount of muscle weakness caused by spending ...
... ... Equals a Charitable Donation to Further the Safe Handling of Hazardous Drugs , ... COLUMBUS, OH (Vocus) April ... “Safe Handling Dance”? In recognition of National Safe Handling Awareness Month (April), Carmel Pharma, ...
Cached Medicine News:Health News:M. D. Anderson zeroes in on better way to predict prognosis in pediatric leukemia patients 2Health News:Kids Often Misled About Child Abuse 2Health News:New England Journal of Medicine Article Trumpets “Priority” Status of Helping Patients Take Medications Correctly 2Health News:New England Journal of Medicine Article Trumpets “Priority” Status of Helping Patients Take Medications Correctly 3Health News:Primary care physicians nationwide face clinical ethical conflicts with religious hospitals 2Health News:Mild Exercise Good for the Critically Ill 2Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 2Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 3Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 4Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 5
(Date:5/22/2015)... CHAPEL HILL, N.C. , May 22, 2015 ... is critical to pharmaceutical brand recognition and success. ... Practices, LLC conducted a study to provide pharmaceutical ... level of investment (FTEs and budget) that are ... companies. Pharmaceutical and biotech marketing managers can utilize ...
(Date:5/22/2015)... , May 22, 2015 The ... in 2014 and is estimated to reach $90.7 million by ... Browse through the TOC of North America Dental ... with the help of various tables and figures. ... 10% customization on this report.   Dental ...
(Date:5/22/2015)... -- The Mesothelioma Victims Center is incredibly passionate about ... best possible compensation, and they are also extremely focused ... caused by exposure to asbestos or their family ... options such as a recent possible medical breakthrough. For ... anytime at 866-714-6466. http://MesotheliomaVictimsCenter.Com ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5
... Benefits Including Stress Reduction, Pain Relief and Improved Sleep ... According to the American Medical Association, stress is a ... The World Health Organization cites stress as America,s No. ... stress a "major health problem." An Arizona entrepreneur, however, ...
... Body mass index (BMI) should be taken into account ... researchers at Cancer Treatment Centers of America ... lower levels of vitamin D compared to non-obese patients. , ... , , The association between vitamin D and obesity ...
Cached Medicine Technology:Scottsdale Facility to Be First in U.S. to Showcase True REST Technology 2Scottsdale Facility to Be First in U.S. to Showcase True REST Technology 3Researchers Say More Aggressive Vitamin D Supplementation Needed in Obese Cancer Patients 2
Inquire...
... Pectoralis Implants come in three styles. Each ... by far the most popular style. Pectoral ... are packaged and sold individually, not in ... they are each made for a specific ...
... The latest software product in the IQmark ... new, more efficient levels of portability, cost-savings and ... is perfect for use in the office, clinics ... and emergency situations. , ,When used in conjunction ...
... EZ Holter is engineered to set a ... you do is enter the patient demographics, ... ,This three-channel, Windows based system uses the ... accuracy and versatility of the IQmark Holter ...
Medicine Products: