Navigation Links
Protein a possible key to allergy and asthma control
Date:1/2/2008

Activating a protein found on some immune cells seems to halt the cells typical job of spewing out substances that launch allergic reactions, a study by Johns Hopkins researchers suggests. The findings could eventually lead to new treatments for allergic reactions ranging from annoying bouts of hay fever to deadly asthma attacks.

Previous studies by Bruce Bochner and his colleagues at the Johns Hopkins Asthma and Allergy Center had zeroed in on the protein, Siglec-8, as an important player in allergic reactions. This protein is found on the surfaces of some types of immune cells, namely eosinophils, basophils and mast cells, which have diverse but cooperative roles in normal immune function and allergic diseases. Eosinophils directly combat foreign invaders, such as parasites. Basophils and mast cells store and release substances such as histamine, prostaglandins and cytokines, which signal other immune system cells to ready for battle.

When functioning correctly, these cells are a valuable aid to keeping the body healthy and infection-free. However, in allergic reactions and asthma attacks, the cells unleash an overwhelming response that typically harms the body more than it helps.

The researchers found in previous studies that when they activated Siglec-8 on the surface of eosinophils, the cells promptly died. Expecting the same suicidal response in mast cells, the scientists tested their theory in a new study on human mast cells and mast-cell-containing tissues.

Using mast cells grown in a lab, the researchers used antibodies to activate Siglec-8. We were surprised to see that these cells just sat there happily in their petri dishes and lived on, says Bochner, director of the Division of Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine.

With their initial theory disproven, Bochner and his colleagues suspected that Siglec-8 might be slowing down other cellular processes ba
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... 31, 2014 In its latest blog post, ... believes that having family close by during a stay in ... the process is successful, is looking at 10 tips to ... , “Addiction recovery is a lifelong process, and one that ... committed to without compromise,” commented Best Drug Rehabilitation’s CEO ...
(Date:7/31/2014)... The study, The Truth Behind ... episode of care payments for four clinical areas—congestive heart ... replacements (hips and knees). Using the definition of ... Care Improvement program, the study examines these clinical areas ... the country. , “Our study reaffirms that, in most ...
(Date:7/30/2014)... 30, 2014 The Mesothelioma ... Penn's Abramson Cancer Center, will host a regional ... experts in the field of mesothelioma. September 26 marks ... is open to the public, and specifically aimed at ... who have been exposed to asbestos. , The conference ...
(Date:7/30/2014)... returning National Guard soldiers were more likely to ... life setbacks, including job loss, legal problems, divorce, ... military families. Results of the study by researchers ... are published online in the American Journal ... a major concern for reservists returning home. Nearly ...
(Date:7/30/2014)... (PRWEB) July 31, 2014 “United States Orthopedic ... data on the United States Orthopedic Braces and Supports market. ... volume (in units) and average price data (in US dollars), ... Supports , Ankle Braces and Supports , ... Braces and Supports. , Orthotics is a specialty ...
Breaking Medicine News(10 mins):Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 3Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 2Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 3Health News:Vets' alcohol problems linked to stress on the home front 2Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 2Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 3Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 4
... released figures which show that there is an incredible ... for rehabilitation treatment programs under the banner of NHS(National ... . ,Most of the centers earmarked for drug ... the in- patient wards are empty and that referral ...
... floor spasm and pain, which may now be relieved by ... symptoms of this condition are heaviness, frequency or urgency in ... Abbott of the Royal Hospital For Women, Randwick conducted a ... effect of botox on women with pelvic spasms.30 women were ...
... Carnegie Mellon University conducted a path breaking study on ... in their ability to differentiate between living and non ... The paper which can be found in the Journal ... to one of the intriguing traits of autism: the ...
... The American College of Surgeons (ACS) has accredited NewYork-Presbyterian ... with the highest possible designation (1A),// in recognition of ... available. The top-level designation is a first for New ... ,An estimated 30 percent of U.S. adults 20 years ...
... a major recent countrywide study, antipsychotic drugs that are ... in treating Alzheimer's disease as most of the patients ... ,This study was conducted by Lon Schneider, professor ... the Keck School of Medicine of the University of ...
... develop pneumococcal pneumonia -- a common bacterial pneumonia that ... October issue of Mayo Clinic Women's HealthSource is spreading ... //against this form of pneumonia and reduces the serious ... unaware of the vaccine, or may not know that ...
Cached Medicine News:Health News:NHS De-addiction, Rehabilitation waiting time ticking into months 2Health News:Autistic Children May Lag behind in ‘Categorization of Objects 2Health News:NewYork-Presbyterian Receives Highest Accreditation for Bariatric Surgery 2
(Date:7/30/2014)... July 30, 2014  Hologic, Inc. (NASDAQ: ... fiscal quarter ended June 28, 2014. Third ... increased 1.0% to $632.6 million, reflecting operational growth of ... to the same period in the prior year. ... segments. , Breast Health revenues grew 3.5%. , ...
(Date:7/30/2014)... YORK, Pa. , July 30, 2014 /PRNewswire/ ... UNIS ; ASX: UNS), a developer and supplier of ... of investments in manufacturing capacity, R&D, and facilities ... biotechnology companies for its products and services. During ... Company invested approximately $16 million in capital expenditures ...
(Date:7/30/2014)... 30, 2014  Today the US Surgeon General issued the ... tanning or sun burns stating they can lead directly to ... Boris Lushniak , says that "skin cancer is a major ... much exposure to indoor and outdoor ultraviolet light is a ... Medicine, in Boca Raton, Florida , ...
Breaking Medicine Technology:Hologic Announces Third Quarter Fiscal 2014 Operating Results 2Hologic Announces Third Quarter Fiscal 2014 Operating Results 3Hologic Announces Third Quarter Fiscal 2014 Operating Results 4Hologic Announces Third Quarter Fiscal 2014 Operating Results 5Hologic Announces Third Quarter Fiscal 2014 Operating Results 6Hologic Announces Third Quarter Fiscal 2014 Operating Results 7Hologic Announces Third Quarter Fiscal 2014 Operating Results 8Hologic Announces Third Quarter Fiscal 2014 Operating Results 9Hologic Announces Third Quarter Fiscal 2014 Operating Results 10Hologic Announces Third Quarter Fiscal 2014 Operating Results 11Hologic Announces Third Quarter Fiscal 2014 Operating Results 12Hologic Announces Third Quarter Fiscal 2014 Operating Results 13Hologic Announces Third Quarter Fiscal 2014 Operating Results 14Hologic Announces Third Quarter Fiscal 2014 Operating Results 15Hologic Announces Third Quarter Fiscal 2014 Operating Results 16Hologic Announces Third Quarter Fiscal 2014 Operating Results 17Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 2Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 3Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 4Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 5Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2
... Stryker Inter-Lock™ System provides fixation ... the tibial fixation site. Inter-Lock™ ... into one implant. It provides ... be used routinely where the ...
... Threaded Dilator System offers ... choice for drilling their ... compaction reaming versus conventional ... bone within the tunnel ...
... for excising soft tissue more efficiently than a ... serrated edge on the straight scissor helps to ... the jaws for more efficient resection.,The curved scissors, ... the perfect tools for ACL stump removal, meniscectomies ...
... Series I Instrument program offers state-of-the-art quality ... while maintaining strength and durability. Low profile ... tight joint spaces. Series I instruments are ... style, size and angle required for large ...
Medicine Products: