Navigation Links
Protein a possible key to allergy and asthma control
Date:1/2/2008

Activating a protein found on some immune cells seems to halt the cells typical job of spewing out substances that launch allergic reactions, a study by Johns Hopkins researchers suggests. The findings could eventually lead to new treatments for allergic reactions ranging from annoying bouts of hay fever to deadly asthma attacks.

Previous studies by Bruce Bochner and his colleagues at the Johns Hopkins Asthma and Allergy Center had zeroed in on the protein, Siglec-8, as an important player in allergic reactions. This protein is found on the surfaces of some types of immune cells, namely eosinophils, basophils and mast cells, which have diverse but cooperative roles in normal immune function and allergic diseases. Eosinophils directly combat foreign invaders, such as parasites. Basophils and mast cells store and release substances such as histamine, prostaglandins and cytokines, which signal other immune system cells to ready for battle.

When functioning correctly, these cells are a valuable aid to keeping the body healthy and infection-free. However, in allergic reactions and asthma attacks, the cells unleash an overwhelming response that typically harms the body more than it helps.

The researchers found in previous studies that when they activated Siglec-8 on the surface of eosinophils, the cells promptly died. Expecting the same suicidal response in mast cells, the scientists tested their theory in a new study on human mast cells and mast-cell-containing tissues.

Using mast cells grown in a lab, the researchers used antibodies to activate Siglec-8. We were surprised to see that these cells just sat there happily in their petri dishes and lived on, says Bochner, director of the Division of Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine.

With their initial theory disproven, Bochner and his colleagues suspected that Siglec-8 might be slowing down other cellular processes ba
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... The world’s largest, most active billionaire/ millionaire ... millionth member, and it has since greatly exceeded the ... dating website for the rich looking for attractive and ... caters like-minded people who are admirers, millionaires and billionaires. ... , this is the place where rich people can ...
(Date:8/22/2014)... 2014 First Choice Emergency Room ... facility is located at 8927 Highway 6, Missouri City, Texas ... is pleased to be a part of the Missouri City ... medical care to our neighbors here,” said Dr. Kenneth Jones, ... , At yesterday’s ribbon cutting with the Fort ...
(Date:8/22/2014)... Toledo, OH (PRWEB) August 22, 2014 Teen ... people in Toledo, OH. The rising numbers of young adults ... have been staggering. To help make a difference in the ... provide a valuable resource for teens seeking to overcome their ... their teens find the best youth rehab center to focus ...
(Date:8/22/2014)... CA (PRWEB) August 22, 2014 Dr Murray ... for this snoring cure. , In the October 2014 issue ... of Dr Grossan about his method of treating snoring, and ... quotes Dr Grossan: "Nearly half of all adults snore occasionally, ... This is because air passages in the back of ...
(Date:8/21/2014)... Os-Monitor.com, an outstanding online supplier of ... monitoring software collection ( http://www.os-monitor.com ). In addition ... all these high end items are offered with ... of improving productivity, the employers pay more attention ... employee and network monitoring software products are becoming ...
Breaking Medicine News(10 mins):Health News:Rich Men & Women Dating Site Billionairefish.com Exceeds Two Million Members 2Health News:Rich Men & Women Dating Site Billionairefish.com Exceeds Two Million Members 3Health News:First Choice Emergency Room Opens New Facility in Missouri City, Texas 2Health News:New Helpline Provides Hope for Troubled Teens in Toledo 2Health News:Dr Murray Grossan Explains how and why Singing Exercises Stop Snoring 2Health News:Dr Murray Grossan Explains how and why Singing Exercises Stop Snoring 3Health News:New Employee Monitoring Software Collection Unveiled By Os-Monitor.com 2
... , , WASHINGTON, Dec. 21 ... the manager,s amendment which includes abortion language that would force ... that will cover any or all abortions while doing nothing ... the legislation has a myriad of other problems including increasing ...
... More than 40 groups have joined together to oppose ... Vigil" starting at 9 pm tonight and wrapping after the ... millions on the left, right, seniors, tea parties, doctors, libertarians, ... for laying a $200 billion windfall in mandatory premiums at ...
... ... named two QHR management clients to its “Top 100 Hospitals: Best ... a QHR management client since 1982, and Monroe County Hospital (Monroeville, ... company, which specializes in providing hospitals and other healthcare-related businesses with ...
... Political ... for biggest lies also include claims by President Barack Obama and Vice President Joe ... Washington ... of the St. Petersburg Times, has named Sarah Palin,s claim about "death panels" the ...
... , WASHINGTON, Dec. 20 Following is the ... http://www.newscom.com/cgi-bin/prnh/20090226/CENSUSLOGO ) , SUNDAY, DECEMBER 20: FIRST ORGAN ... The first successful organ transplant in the U.S. was performed this ... He transplanted a kidney from one identical twin to another, who ...
... care focuses on costs, a new study from North Carolina ... think of health care spending as an investment that can ... of health care costs and financing may be unduly pessimistic. ... in future capital, contributing to a productive workforce, rather than ...
Cached Medicine News:Health News:FRC Asks - 'Is There No Democratic Senator Who Cares About Life?' 2Health News:Left/Right Healthcare 'Virtual Vigil' Tonight at 9 PM Until Senate Votes; Broad Coalition Says Punishes Some States, Windfall for Insurance Companies 2Health News:QHR Hospital Clients Fort Madison Community Hospital, Monroe County Hospital Named to “Best in Value” Top 100 List 2Health News:PolitiFact Names 'Death Panels' Claim the Lie of the Year 2Health News:U.S. Census Bureau Daily Feature for Dec. 20 2Health News:Study shows health care spending spurs economic growth 2
(Date:8/21/2014)... Germany , Aug. 21, 2014  IBM (NYSE: ... Elektronen-Synchrotron ( DESY ), a leading national research center ... management and storage of massive volumes of x-ray data. ... based on IBM software defined technology can handle more ... performance and help scientists worldwide gain faster insights into ...
(Date:8/21/2014)... 2014  Seventy-one percent of Americans believe the abuse of ... public health and safety issue in the United ... today by Repass & Partners, a Cincinnati ... the severity of the prescription medication abuse problem and the ... serious health situation facing our country," Rex Repass , ...
(Date:8/21/2014)... 2014 BreedIT Corp., (OTCQB: ... exclusive worldwide license holder and distributor of highly ... researchers, today is pleased to announce the formation ... Ltd, a leading Israeli medical Cannabis breeder. ... new breeds of medical Cannabis to meet the ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... BUDAPEST, Hungary , January ... Globally Licenses ChemAxon,s Platform For Markush Structure,Searching And Enumeration , ... cheminformatics software for the life,sciences industry has entered into agreement ... for global,development and deployment within Pfizer,s global R&D facilities. , ...
... ... to Improve Walking for People With All Types of Multiple Sclerosis ... The U.S. Food and Drug Administration has approved the marketing of ... its ability to improve walking speed in people with any type ...
Cached Medicine Technology:Ampyra is First Symptom Management Drug Developed Specifically to Treat MS, the First Oral MS Therapy Approved for MS, and the First New FDA Approved Therapy to Come Through the MS Pipeline Since 2004 2Ampyra is First Symptom Management Drug Developed Specifically to Treat MS, the First Oral MS Therapy Approved for MS, and the First New FDA Approved Therapy to Come Through the MS Pipeline Since 2004 3Ampyra is First Symptom Management Drug Developed Specifically to Treat MS, the First Oral MS Therapy Approved for MS, and the First New FDA Approved Therapy to Come Through the MS Pipeline Since 2004 4Ampyra is First Symptom Management Drug Developed Specifically to Treat MS, the First Oral MS Therapy Approved for MS, and the First New FDA Approved Therapy to Come Through the MS Pipeline Since 2004 5Ampyra is First Symptom Management Drug Developed Specifically to Treat MS, the First Oral MS Therapy Approved for MS, and the First New FDA Approved Therapy to Come Through the MS Pipeline Since 2004 6
... Slab Gel Dryer accommodates large sequencing gels or multiple ... coated platen for long lasting durability and corrosion resistance., ... , Quick Drying Rate - large sequence ... , Digital display of temperature and time ...
... The Slimline SGD5040 Slab Gel Dryer incorporates sturdy metal ... saving design. The large surface area makes it perfect ... ones., Slim Profile 40cm x 50cm (W ... Heat Ramping Rates allows you to optimize ...
... midi gel dryer can dry 6 pieces of 10 ... area is 21 x 31 cm for laboratories to ... of silicon rubber with mask. Microprocessor controller controls temperature ... and the vacuum removes the moisture from below to ...
... dry gels rapidly, evenly and safely, the Hoefer ... and vacuum are applied beneath the gel through ... and agarose gels up to 33 x 44 ... heavy aluminum platen provides even heat distribution and ...
Medicine Products: